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Misakinolide-A, an antitumor macrolide from the marine sponge Theonella sp.
Title
Misakinolide-A, an antitumor macrolide from the marine sponge Theonella sp.
Creator
Sakai, R., Higa, T., Kashman, Y., Harbor Branch Oceanographic Institute
Date Issued
1986
PURL
http://purl.flvc.org/FCLA/DT/3343807
Subject Headings
Sponges, Antitumor agents, Macrolides
Format
Document (PDF)
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
Title
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator
Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3333011
Subject Headings
Sponges, Macrolides, Marine natural products
Format
Document (PDF)
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina
Title
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina.
Creator
Lawry, Joseph, Kerr, Russell G., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia,...
Show moreThe bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia, melanoma and nephrotoma. A series of experiments was undertaken to elucidate the biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme preparation and radiolabelled precursors. A regional characterization of Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also described.
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Date Issued
1997
PURL
http://purl.flvc.org/fau/fd/FA00000787
Subject Headings
Macrolide antibiotics, Bryozoa, Marine pharmacology
Format
Document (PDF)
Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol
Title
Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol.
Creator
Paterson, Ian, Naylor, G. J., Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
Date Issued
2011
PURL
http://purl.flvc.org/fau/fd/FA00007463
Subject Headings
Macrolides, Antimitotic Agents, Natural products, Tubulin
Format
Document (PDF)
Lasonolide A, a new cytotoxic macrolide from the marine sponge Forcepia sp.
Title
Lasonolide A, a new cytotoxic macrolide from the marine sponge Forcepia sp.
Creator
Horton, P. A., Koehn, F. E., Longley, Ross E., McConnell, O. J., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3319075
Subject Headings
Sponges --Research, Antineoplastic agents, Marine natural products, Macrolides
Format
Document (PDF)
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
Title
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
Creator
Paterson, Ian, Naylor, G. J., Wright, Amy E.
Date Issued
2008
PURL
http://purl.flvc.org/fau/fd/FA00007062
Subject Headings
Antineoplastic agents, Macrolides, Polyketides, Tubulin Modulators, Marine natural products, Sponges
Format
Document (PDF)
Synthesis and biological evaluation of 10, 11-Dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin
Title
Synthesis and biological evaluation of 10, 11-Dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
Creator
Paterson, Ian, Gardner, Nicola M., Poullennec, Karine G., Wright, Amy E.
Date Issued
2008
PURL
http://purl.flvc.org/FCLA/DT/3333013
Subject Headings
Macrolides, Antineoplastic agents, Biological evaluation, Synthesis, Antimitotic agents
Format
Document (PDF)
Early effects of Lasonolide A on pancreatic cancer cells
Title
Early effects of Lasonolide A on pancreatic cancer cells.
Creator
Isbrucker, Richard A., Guzman, Esther A., Pitts, Tara P., Wright, Amy E.
Date Issued
2000
PURL
http://purl.flvc.org/fau/fd/FA00007053
Subject Headings
Macrolides, Sponges, Marine natural products, Pancreatic Neoplasms, Pancreas--Cancer
Format
Document (PDF)
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: structure revision of misakinolide A
Title
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: structure revision of misakinolide A.
Creator
Kato, Y., Fusetani, N., Matsunaga, S., Hashimoto, K., Sakai, R., Higa, T., Kashman, Y., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353820
Subject Headings
Sponges, Antineoplastic agents, Macrolides, Chemical structure, Marine natural products
Format
Document (PDF)
Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
Title
Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
Creator
Wright, Amy E., Chen, Ying, Winder, Priscilla L., Pitts, Tara P., Pomponi, Shirley A., Longley, Ross E.
Date Issued
2004
PURL
http://purl.flvc.org/FCLA/DT/3164109
Subject Headings
Macrolide antibiotics, Natural products, Mass spectrometry, Sponges, Stereochemistry
Format
Document (PDF)
Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
Title
Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
Creator
Paterson, Ian, Britton, R., Delgado, Oscar, Wright, Amy E.
Date Issued
2004
PURL
http://purl.flvc.org/fau/fd/FA00007061
Subject Headings
Macrolides, Sponges, Tubulin Modulators, Stereochemistry, Microtubules, Polyketides, Antimitotic Agents
Format
Document (PDF)
Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
Title
Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
Creator
Paterson, Ian, Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzman, Esther A., Isbrucker, Richard A., Pitts, Tara P., Linley, P. A., Divlianska, D. B., Reed, John K., Wright, Amy E.
Date Issued
2011
PURL
http://purl.flvc.org/fau/fd/FA00007465
Subject Headings
Antimitotic Agents, Macrolides, Sponges, Molecular structure, Nuclear Magnetic Resonance, Biomolecular, Cell lines
Format
Document (PDF)