Current Search: Macrolide antibiotics (x)
-
-
Title
-
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina.
-
Creator
-
Lawry, Joseph, Kerr, Russell G., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
-
Abstract/Description
-
The bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia,...
Show moreThe bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia, melanoma and nephrotoma. A series of experiments was undertaken to elucidate the biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme preparation and radiolabelled precursors. A regional characterization of Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also described.
Show less
-
Date Issued
-
1997
-
PURL
-
http://purl.flvc.org/fau/fd/FA00000787
-
Subject Headings
-
Macrolide antibiotics, Bryozoa, Marine pharmacology
-
Format
-
Document (PDF)
-
-
Title
-
Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
-
Creator
-
Wright, Amy E., Chen, Ying, Winder, Priscilla L., Pitts, Tara P., Pomponi, Shirley A., Longley, Ross E.
-
Date Issued
-
2004
-
PURL
-
http://purl.flvc.org/FCLA/DT/3164109
-
Subject Headings
-
Macrolide antibiotics, Natural products, Mass spectrometry, Sponges, Stereochemistry
-
Format
-
Document (PDF)
