Current Search: Insulin-Like Growth Factor I. (x)
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Title
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Effects of Resistance and Aerobic Training on IGF-1 and BDNF Expression in a Murine Model of Alzheimer’s Disease.
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Creator
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Pena, Gabriel S., Whitehurst, Michael, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
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Abstract/Description
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The primary purpose of this study was to investigate the effects of aerobic and resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention groups underwent 9 weeks of exercise training. Motor behavior and grip strength were measured pre- and post- intervention. Our results showed a significant increase in...
Show moreThe primary purpose of this study was to investigate the effects of aerobic and resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention groups underwent 9 weeks of exercise training. Motor behavior and grip strength were measured pre- and post- intervention. Our results showed a significant increase in hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice were found to have higher concentrations of IGF-I, and improved motor behavior when compared to RT and CNT. No significant differences were observed in IGF-I concentration between RT and other groups. RT improved grip strength after nine weeks of training. These findings support the use of AT and RT as a tool to improve comorbidities found in Alzheimer’s disease.
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Date Issued
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2018
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PURL
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http://purl.flvc.org/fau/fd/FA00013094
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Subject Headings
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Alzheimer's disease., Insulin-Like Growth Factor I., Brain-Derived Neurotrophic Factor, Aerobic exercises., Resistance Training.
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Format
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Document (PDF)
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Title
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ACUTE RESPONSE OF NEUROPROTECTIVE ASSOCIATED BIOMARKERS TO VARIOUS COMPOUND RESISTANCE EXERCISES IN WELL-TRAINED MEN.
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Creator
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Johnson, Trevor K., Zourdos, Michael C., Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
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Abstract/Description
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This study examined if multi-joint resistance exercises could elicit expression of biomarkers associated with neuroprotection. Thirteen well-trained males performed 4 sets to failure at 80% of a one-repetition maximum (1RM) on the back squat, bench press, and deadlift. The biomarkers measured immediately pre- and post-exercise were brain derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), cathepsin B (CatB), and interleukin 6 (IL-6). There was a main time effect (p0.05)....
Show moreThis study examined if multi-joint resistance exercises could elicit expression of biomarkers associated with neuroprotection. Thirteen well-trained males performed 4 sets to failure at 80% of a one-repetition maximum (1RM) on the back squat, bench press, and deadlift. The biomarkers measured immediately pre- and post-exercise were brain derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), cathepsin B (CatB), and interleukin 6 (IL-6). There was a main time effect (p<0.01) for BDNF with significant increases in the deadlift (p=0.01) and bench press (p=0.01) conditions, but not the squat (p=0.21). There was a main time effect (p<0.01) for IL-6 with a significant increase in the squat (p<0.01). There was no significant increase in CatB or IGF-1 (p>0.05). Additionally, there was no significant relationship between BDNF and IL-6 response.
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Date Issued
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2019
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PURL
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http://purl.flvc.org/fau/fd/FA00013322
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Subject Headings
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Biomarkers, Neuroprotection, Resistance Training, Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor I, Cathepsin B, Interleukin-6, Men.
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Format
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Document (PDF)
