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Title: Lobomycosis in bottlenose dolphins: spatial aggregation of an emerging infectious disease.
Creator: Reif, John S., Murdoch, M. Elizabeth, Mazzoil, Marilyn S., Fair, Patricia A., Bossart, Gregory D.
Date Issued: 2006
PURL: http://purl.flvc.org/fau/fd/FA00007362
Subject Headings: Bottlenose dolphin, Lobomycosis, Emerging infectious diseases
Format: Document (PDF)

Title: PHYSIOLOGICAL CHANGES IN LIVERS OF SUCKLING MICE: RESPONSES TO SERA AND WHITE BLOOD CELLS FROM HORSES INFECTED WITH EQUINE INFECTIOUS ANEMIA VIRUS.
Creator: MARTYN, RAYMOND DEWINT, JR., Florida Atlantic University
Abstract/Description: Newborn, albino Swiss mice were inoculated with either infectious EIA material or a normal, negative control sample o At weekly intervals, one mouse from each group was sacrificed and its liver assayed for xanthine oxidase activity, nitrogen content, and its relative weight. By the third week of age, mice which had received an infected inoculum displayed no outward signs of illness; yet, on examination, their livers were higher in xanthine oxidase activity, had a greater concentration of...
Show moreNewborn, albino Swiss mice were inoculated with either infectious EIA material or a normal, negative control sample o At weekly intervals, one mouse from each group was sacrificed and its liver assayed for xanthine oxidase activity, nitrogen content, and its relative weight. By the third week of age, mice which had received an infected inoculum displayed no outward signs of illness; yet, on examination, their livers were higher in xanthine oxidase activity, had a greater concentration of nitrogen, and were smaller in size to those of litter mates which had been injected with non-infected material o These effects were accomplished by either infected horse serum or a suspension of white blood cells from an infected horse. In addition, the same effects were demonstrable with either chronic serum from a febrile period, or serum from a true asymptomatic carrier state. White blood cells from an inapparent carrier were unable to induce elevated responses in young mice.
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Date Issued: 1971
PURL: http://purl.flvc.org/fcla/dt/13435
Subject Headings: Equine infectious anemia, Horses--Diseases
Format: Document (PDF)

Title: IDENTIFIABILITY ANALYSIS AND OPTIMAL CONTROL OF INFECTIOUS DISEASES EPIDEMICS AND PARAMETERIZATION METHOD FOR (UN)STABLE MANIFOLDS OF IMPLICITLY DEFINED DYNAMICAL SYSTEMS.
Creator: Neupane Timsina, Archana, Tuncer, Necibe, Mireles James, Jason D., Florida Atlantic University, Department of Mathematical Sciences, Charles E. Schmidt College of Science
Abstract/Description: This dissertation is a study about applied dynamical systems on two concentrations. First, on the basis of the growing association between opioid addiction and HIV infection, a compartmental model is developed to study dynamics and optimal control of two epidemics; opioid addiction and HIV infection. We show that the disease-free-equilibrium is locally asymptotically stable when the basic reproduction number R0 = max(Ru0; Rv0) 1 and it is locally asymptotically stable when the invasion...
Show moreThis dissertation is a study about applied dynamical systems on two concentrations. First, on the basis of the growing association between opioid addiction and HIV infection, a compartmental model is developed to study dynamics and optimal control of two epidemics; opioid addiction and HIV infection. We show that the disease-free-equilibrium is locally asymptotically stable when the basic reproduction number R0 = max(Ru0; Rv0) < 1; here Rv0 is the reproduction number of the HIV infection, and Ru0 is the reproduction number of the opioid addiction. The addiction-only boundary equilibrium exists when Ru0 > 1 and it is locally asymptotically stable when the invasion number of the opioid addiction is Ruinv < 1: Similarly, HIV-only boundary equilibrium exists when Rv0 > 1 and it is locally asymptotically stable when the invasion number of the HIV infection is Rvinv < 1. We study structural identifiability of the parameters, estimate parameters employing yearly reported data from Central for Disease Control and Prevention (CDC), and study practical identifiability of estimated parameters. We observe the basic reproduction number R0 using the parameters. Next, we introduce four distinct controls in the model for the sake of control approach, including treatment for addictions, health care education about not sharing syringes, highly active anti-retroviral therapy (HAART), and rehab treatment for opiate addicts who are HIV infected. US population using CDC data, first applying a single control in the model and observing the results, we better understand the influence of individual control. After completing each of the four applications, we apply them together at the same time in the model and compare the outcomes using different control bounds and state variable weights. We conclude the results by presenting several graphs.
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Date Issued: 2022
PURL: http://purl.flvc.org/fau/fd/FA00013970
Subject Headings: Dynamical systems, Infectious diseases, Parameter estimation
Format: Document (PDF)

Title: Using Synthetic Biology to Create a Safe and Stable Ebola Surrogate for Effective Development of Detection and Therapy Platforms.
Creator: Holmes, Douglas, Esiobu, Nwadiuto, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description: Ebolavirus is responsible for a deadly hemorrhagic fever that has claimed thousands of lives in Africa and could become a global health threat. Because of the danger of infection, novel Ebola research is restricted to BSL-4 laboratories; this slows progress due to both the cost and expertise required to operate these laboratories. The development of a safe surrogate would speed research and reduce risk to researchers. Two highly conserved Ebola gene segments—from the glycoprotein and...
Show moreEbolavirus is responsible for a deadly hemorrhagic fever that has claimed thousands of lives in Africa and could become a global health threat. Because of the danger of infection, novel Ebola research is restricted to BSL-4 laboratories; this slows progress due to both the cost and expertise required to operate these laboratories. The development of a safe surrogate would speed research and reduce risk to researchers. Two highly conserved Ebola gene segments—from the glycoprotein and nucleoprotein genes—were designed with modifications preventing expression while maintaining sequence integrity, spliced into high copy number plasmids, cloned into E.coli, and tested for stability, safety, and potential research applications. The surrogates were stable over 2-3 months, had a negligible mutation rate (<0.165% over the experiment), and were detectable in human blood down to 5.8E3-1.17E4 surrogates/mL. These protocols could be used to safely simulate other pathogens and promote infectious disease treatment and detection research.
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Date Issued: 2018
PURL: http://purl.flvc.org/fau/fd/FA00013015
Subject Headings: Ebolavirus, Infectious disease research, Ebola virus disease, Synthetic biology
Format: Document (PDF)

Title: CELL CULTURE RESPONSES TO EQUINE INFECTIOUS ANEMIA VIRUS.
Creator: MANKAMYER, MARY PAT, Florida Atlantic University
Abstract/Description: Liver, kidney and spleen cells from healthy horses and horses with equine infectious anemia were cultured in vitro. Primary culture of organs from healthy horses yielded typical elongate fibroblast cells. Primary culture of organs from diseased horses yielded a variety of cell types; pleomorphic giant cells being most common. The giant cells did not divide, but either underwent degeneration and death or became transformed into squamous-like cells lacking contact inhibition resulting in the...
Show moreLiver, kidney and spleen cells from healthy horses and horses with equine infectious anemia were cultured in vitro. Primary culture of organs from healthy horses yielded typical elongate fibroblast cells. Primary culture of organs from diseased horses yielded a variety of cell types; pleomorphic giant cells being most common. The giant cells did not divide, but either underwent degeneration and death or became transformed into squamous-like cells lacking contact inhibition resulting in the production of foci. Inoculation of normal equine fibroblasts with either serum, plasma, or liver, kidney or spleen extracts from diseased horses resulted in a proliferation of the fibroblasts. Normal liver or kidney fibroblasts cocultivated with equine leucocytes and inoculated with serum or plasma from a diseased horse became transformed. This research supports the proposal that equine infectious anemia virus is an oncornavirus.
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Date Issued: 1974
PURL: http://purl.flvc.org/fcla/dt/13651
Subject Headings: Equine infectious anemia, Horses--Diseases, Cell culture
Format: Document (PDF)

Title: PREPARATION, PARTIAL PURIFICATION AND CHARACTERIZATION OF AN EQUINE INFECTIOUS ANEMIA ANTIGEN.
Creator: HETRICK, DANIEL L., Florida Atlantic University
Abstract/Description: An antigenic material was extracted from the leukocytes of horses infected with Equine Infectious Anemia. In unmodified form, this material was infectious, immunogenic, and antigenic. After modification by anti-viral agents and cross-linkage to rabbit gamma globulin, the material retained its immunogenic and antigenic properties, but became non-infectious. Inoculation of the non-infectious antigen into experimental horses elicited antibody production. When these horses were challenged with...
Show moreAn antigenic material was extracted from the leukocytes of horses infected with Equine Infectious Anemia. In unmodified form, this material was infectious, immunogenic, and antigenic. After modification by anti-viral agents and cross-linkage to rabbit gamma globulin, the material retained its immunogenic and antigenic properties, but became non-infectious. Inoculation of the non-infectious antigen into experimental horses elicited antibody production. When these horses were challenged with live virus, the classical symptoms of the disease did not appear. The possibility exists that a protective vaccine was developed from modified antigen preparations.
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Date Issued: 1973
PURL: http://purl.flvc.org/fcla/dt/13611
Subject Headings: Equine infectious anemia--Immunological aspects, Horses--Diseases
Format: Document (PDF)

Title: RELATION OF SERUM CALCIUM AND FERRITIN LEVELS TO SIDEROLEUKOCYTE FORMATION IN EQUINE INFECTIOUS ANEMIA.
Creator: MCCORQUODALE, DONALD SINCLAIR, JR., Florida Atlantic University
Abstract/Description: It has been shown that sideroleukocyte formation in equine infectious anemia is related to the presence of detectable amounts of ferritin in the serum of the infected animal. The presence of ferritin has been associated with tissue breakdown as a result of the infectious process. A relatively simple agar diffusion technique has been reported which is of value in the screening of horses for the acute phase of equine infectious anemia. It has further been shown that infected leukocytes can be...
Show moreIt has been shown that sideroleukocyte formation in equine infectious anemia is related to the presence of detectable amounts of ferritin in the serum of the infected animal. The presence of ferritin has been associated with tissue breakdown as a result of the infectious process. A relatively simple agar diffusion technique has been reported which is of value in the screening of horses for the acute phase of equine infectious anemia. It has further been shown that infected leukocytes can be induced to form sideroleukocytes earlier and in greater number by the addition of ferritin or calcium. Non-infected horses can not be induced to form sideroleukocytes by the addition of only ferritin or calcium or infected sera. However, addition of both ferritin and calcium does cause induction of sideroleukocytes in normal leukocytes. Levels of serum calcium in infected horses were shown to be inversely proportional to both temperature of the animal and the formation of sideroleukocytes. The data indicated the important role of serum levels of ferritin and calcium to the mechanism of sideroleukocyte formation both in vivo and in vitro.
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Date Issued: 1971
PURL: http://purl.flvc.org/fcla/dt/13436
Subject Headings: Equine infectious anemia, Horses--Diseases, Ferritin, Leucocytes
Format: Document (PDF)

Title: Indirect Passive Hemagglutination as a Diagnostic Test for Equine Infectious Anemia.
Creator: Flynn, John Howard, Waddell, Glenn H., Florida Atlantic University
Abstract/Description: The disease of equine infectious anemia (EIA), since the first records in 1847, has been one of the most serious and deadly virus diseases of the Equidae. The most difficult factor concerning this disease was adequate diagnosis. The clinical diagnosis has proven itself undependable and until 1966 with the Immune-adherence test the laboratory diagnosis was inconclusive. The indirect passive hemagglutination test was used as a possible test for the disease due to its high sensitivity. The...
Show moreThe disease of equine infectious anemia (EIA), since the first records in 1847, has been one of the most serious and deadly virus diseases of the Equidae. The most difficult factor concerning this disease was adequate diagnosis. The clinical diagnosis has proven itself undependable and until 1966 with the Immune-adherence test the laboratory diagnosis was inconclusive. The indirect passive hemagglutination test was used as a possible test for the disease due to its high sensitivity. The indirect passive hemagglutination as the diagnostic test for EIA was based on the use of antibody as the titrating agent instead of the virus. The antibody was removed from the sera of infected horses. The seperation of the antibody was accomplished by use of a DEAE-cellulose column and an increasing salt gradient. The various proteins were sepRrated and measured in a spectrophotometer. The antibody portion was collected and concentrated by polyethylene gycol. The more specific type of antibody (19S) was used in all tests. The indirect passive hemagglutination test was run on a total of 92 sera of which 58 were negative and 34 sera were positive. The test proved reliable in all the sera tested. In support of the IPHA the IA test was run as a comparison.
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Date Issued: 1967
PURL: http://purl.flvc.org/fau/fd/FA00000758
Subject Headings: Equine infectious anemia, Horses--Diseases, Hemagglutination tests
Format: Document (PDF)

Title: EVALUATION OF A GAMMA-IRRADIATED, GAMMA GLOBULIN COUPLED, PARTIALLY PURIFIED MATERIAL AS AN IMMUNIZING AGENT FOR EQUINE INFECTIOUS ANEMIA (EIA).
Creator: BELTRANENA, HUMBERTO PEDRO PABLO., Florida Atlantic University, Saurino, Vincent R.
Abstract/Description: Leukocytes, harvested from EIA infected horse plasma, were disrupted and partially purified by differential centrifugation. This material was assayed for its capacity to inhibit migration of leukocytes from infected horses. After 6 X 10^6 r of gamma radiation the material was reassayed and 85% of the initial activity remained, indicating that little antigenic destruction had occurred. This material was coupled to rabbit gamma globulin and used for horse inoculation. The above material,...
Show moreLeukocytes, harvested from EIA infected horse plasma, were disrupted and partially purified by differential centrifugation. This material was assayed for its capacity to inhibit migration of leukocytes from infected horses. After 6 X 10^6 r of gamma radiation the material was reassayed and 85% of the initial activity remained, indicating that little antigenic destruction had occurred. This material was coupled to rabbit gamma globulin and used for horse inoculation. The above material, uncoupled, and a partially purified irradiated normal horse protein material were used as controls. Responses to immunizations and challenges were monitored. Uncoupled irradiated material produced the disease. Coupled irradiated material did not produce the disease and the immunized horse was resistant to challenge with 1 ml of a 10^-3 dilution of infectious serum for 30 days and, then, to 1 ml of undiluted infectious serum for 30 more days .
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Date Issued: 1973
PURL: http://purl.flvc.org/fcla/dt/13566
Subject Headings: Equine infectious anemia--Immunological aspects, Horses--Diseases
Format: Document (PDF)

Title: Migration induced epidemics: dynamics of flux-based multipatch models.
Creator: Liebovitch, Larry S., Schwartz, Ira B.
Date Issued: 2004
PURL: http://purl.flvc.org/FAU/165227
Subject Headings: Communicable diseases--Epidemiology--Mathematical models, Emerging infectious diseases, Epidemiologic Methods, Epidemiology, Biomathematics, Medicine-Mathematics, Dynamics-Mathematical models
Format: Document (PDF)

Title: Infectious hypodermal and hematopoietic necrosis (IHHN) virus transmission in Litopenaeus vannamei: Salinity influence in disease expression.
Creator: de Morales, M. M., Laramore, Susan E., Laramore, C. R., Morales, F., Scarpa, John
Date Issued: 2007
PURL: http://purl.flvc.org/FCLA/DT/3340516
Subject Headings: Litopenaeus vannamei, Infectious hematopoietic necrosis virus, Salinity, Communicable diseases--Transmission, Whiteleg shrimp
Format: Document (PDF)

Title: From monsoons to microbes: understanding the ocean's role in human health.
Creator: National Research Council (U.S.) Committee on the Ocean’sRole in Human Health, Pomponi, Shirley A.
Date Issued: 1999
PURL: http://purl.flvc.org/fau/fd/FA00007391
Subject Headings: Marine pollution -- Health aspects, Marine pharmacology, Biomedical Research, Infectious Diseases, Algal blooms--Health aspects
Format: Document (PDF)

Title: Dynamical response of multi-patch, flux-based models to the input of infected people: epidemic response to initiated events.
Creator: Liebovitch, Larry S., Schwartz, Ira B., Rho, Young-Ah
Date Issued: 2008-07-21
PURL: http://purl.flvc.org/FAU/165229
Subject Headings: Communicable diseases--Epidemiology--Mathematical models, Epidemiologic Methods, Differential equations, Dynamics--Mathematical models, Spatial systems--Mathematical models, Population dynamics, Emerging infectious diseases
Format: Document (PDF)

FAU Theses and Dissertations (8)	+ -
HBOI Faculty Contributions (3)	+ -
FAU College Collections (2)	+ -

Horses--Diseases (6)	+ -
Equine infectious anemia (4)	+ -
Emerging infectious diseases (3)	+ -
Communicable diseases--Epidemiology--Mathematical models (2)	+ -
Epidemiologic Methods (2)	+ -

Equine infectious anemia--Immunological aspects (2)	+ -
Algal blooms--Health aspects (1)	+ -
Biomathematics (1)	+ -
Biomedical Research (1)	+ -
Bottlenose dolphin (1)	+ -
Cell culture (1)	+ -
Communicable diseases--Transmission (1)	+ -
Differential equations (1)	+ -
Dynamical systems (1)	+ -
Dynamics--Mathematical models (1)	+ -
Dynamics-Mathematical models (1)	+ -
Ebola virus disease (1)	+ -
Ebolavirus (1)	+ -
Epidemiology (1)	+ -
Ferritin (1)	+ -
Hemagglutination tests (1)	+ -
Infectious Diseases (1)	+ -
Infectious disease research (1)	+ -
Infectious diseases (1)	+ -
Infectious hematopoietic necrosis virus (1)	+ -
Leucocytes (1)	+ -
Litopenaeus vannamei (1)	+ -
Lobomycosis (1)	+ -
Marine pharmacology (1)	+ -
Marine pollution -- Health aspects (1)	+ -

Electronic Thesis or Dissertation (8)	+ -
article (4)	+ -
table of contents (1)	+ -

English (13)	+ -
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