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immunology of green turtle fibropapillomatosis
Title
The immunology of green turtle fibropapillomatosis.
Creator
Varela, Rene A., Florida Atlantic University, Lutz, Peter L.
Abstract/Description
Green Turtle Fibropapillomatosis has been a disease of intense investigation, with little ascertained as to its cause. This investigation thus delved into the possible link between this disease and immune compromise. This was achieved by creating three groups of animals, one characterized as healthy another as diseased, and a third as recovered. Blood taken from each animal was then applied to the four aspects of our investigation: general chemistry, hematology, specialized chemistry, and in...
Show moreGreen Turtle Fibropapillomatosis has been a disease of intense investigation, with little ascertained as to its cause. This investigation thus delved into the possible link between this disease and immune compromise. This was achieved by creating three groups of animals, one characterized as healthy another as diseased, and a third as recovered. Blood taken from each animal was then applied to the four aspects of our investigation: general chemistry, hematology, specialized chemistry, and in vitro cell proliferation to establish the best diagnostic cues. General chemistry, hematology, and specialized chemistry proved to be inconsequential in elucidating the effects of possible immune compromise. In vitro cell proliferation, though, proved conclusively that t and b like cells were severely depressed in diseased and "recovered" animals, giving conclusive evidence of immune dysfunction in association with fibropapillomatosis.
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Date Issued
1997
PURL
http://purl.flvc.org/fcla/dt/15518
Subject Headings
Green turtle--Diseases, Green turtle--Immunology
Format
Document (PDF)
Fibropapillomatosis in stranded green turtles (Chelonia mydas) in Florida: 20 years of spatiotemporal trends and associations with environmental factors
Title
Fibropapillomatosis in stranded green turtles (Chelonia mydas) in Florida: 20 years of spatiotemporal trends and associations with environmental factors.
Creator
Niland, Hannah, Perrault, Justin, Salmon, Michael, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
Abstract/Description
Fibropapillomatosis (FP) is a tumor disease that has reached panzootic proportions in green turtles (Chelonia mydas). FP is associated with chelonid alphaherpesvirus 5, although the etiology of FP is likely multifactorial, since high FP prevalence is often observed in degraded habitats. However, specific environmental cofactors for tumor development remain unknown. To explore this, I collated statewide green turtle stranding data from 2000–2020 to evaluate spatiotemporal trends of FP in...
Show moreFibropapillomatosis (FP) is a tumor disease that has reached panzootic proportions in green turtles (Chelonia mydas). FP is associated with chelonid alphaherpesvirus 5, although the etiology of FP is likely multifactorial, since high FP prevalence is often observed in degraded habitats. However, specific environmental cofactors for tumor development remain unknown. To explore this, I collated statewide green turtle stranding data from 2000–2020 to evaluate spatiotemporal trends of FP in Florida, and co-analyzed these data alongside patterns of river flow, chlorophyll-a (Chla), sea surface temperature (SST), El Niño (ENSO), and red tide (HAB). I found that FP was stable during 2000–2020. HAB (positively) and SST (negatively) correlated with statewide FP prevalence, as well as several interactions between various factors. These results suggest that SST and HABs may act as cofactors in the development of FP, and future work should be equally interdisciplinary in their investigation of this multifactorial disease
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Date Issued
2023
PURL
http://purl.flvc.org/fau/fd/FA00014191
Subject Headings
Green sea turtles, Chelonia mydas, Sea turtles--Diseases
Format
Document (PDF)
Stress protein expression and green turtle fibropapillomatosis
Title
Stress protein expression and green turtle fibropapillomatosis.
Creator
McGarrity, Monica E., Florida Atlantic University, Milton, Sarah L.
Abstract/Description
Green turtle fibropapillomatosis (GTFP) is a highly debilitating disease that affects several species of marine turtles worldwide. This study evaluated stress protein expression in red blood cells (RBCs), skin and tumors of green turtles (Chelonia mydas) from a GTFP-prevalent site and a more pristine, GTFP-free site. Levels of expression of HSP72 were significantly higher in healthy turtles from the GTFP-prevalent site compared to healthy turtles from the GTFP-free site, suggesting that these...
Show moreGreen turtle fibropapillomatosis (GTFP) is a highly debilitating disease that affects several species of marine turtles worldwide. This study evaluated stress protein expression in red blood cells (RBCs), skin and tumors of green turtles (Chelonia mydas) from a GTFP-prevalent site and a more pristine, GTFP-free site. Levels of expression of HSP72 were significantly higher in healthy turtles from the GTFP-prevalent site compared to healthy turtles from the GTFP-free site, suggesting that these turtles are, indeed stressed. Levels of HSP72 expression were also significantly higher in the nucleated RBCs than in skin tissues of turtles from both sites. These results demonstrate the utility of RBC stress protein evaluation as a new, minimally invasive method of evaluating stress loads in marine turtles as a factor in the potentially multifactorial etiology of GTFP. In addition, HSP72 and GP96 were present and detectable in tumors of diseased turtles, and thus show potential for use in treatment of GTFP.
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Date Issued
2005
PURL
http://purl.flvc.org/fcla/dt/13269
Subject Headings
Green turtle--Diseases, Green turtle--Immunology, Stress (Physiology), Environmental monitoring
Format
Document (PDF)
Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis
Title
Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis.
Creator
Deming, Alissa C., Milton, Sarah L., Florida Atlantic University
Abstract/Description
Fibropapillomatosis (FP) is a devastating pandemic characterized by benign cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to survive. HSP72 and GRP96 are also known to initiate an immune response and may contribute to the regression often observed in FP tumors. Results were found that...
Show moreFibropapillomatosis (FP) is a devastating pandemic characterized by benign cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to survive. HSP72 and GRP96 are also known to initiate an immune response and may contribute to the regression often observed in FP tumors. Results were found that showed all three protective proteins had significantly higher levels in actively growing tumor tissue compared to healthy tissue. Specifically, cauliflower-like tumors, thought to be actively growing, were found to have higher levels of HSP72 and GRP96 compared to healthy skin, whereas smooth tumors, thought to be regressing, did not. These results offer insight into the molecular mechanisms behind the development of FP tumors and open a number of avenues for future research.
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Date Issued
2008
PURL
http://purl.flvc.org/fau/fd/FA00000740
Subject Headings
Stress (Physiology), Green turtle--Diseases, Environmental monitoring, Green turtle--Immunology
Format
Document (PDF)
INFLUENCE OF UV LIGHT ON VITAMIN D AND IMMUNE FUNCTION OF GREEN (CHELONIA MYDAS) SEA TURTLES WITH FIBROPAPILLOMATOSIS
Title
INFLUENCE OF UV LIGHT ON VITAMIN D AND IMMUNE FUNCTION OF GREEN (CHELONIA MYDAS) SEA TURTLES WITH FIBROPAPILLOMATOSIS.
Creator
Garefino, Victoria E., Milton, Sarah L., Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
Abstract/Description
Green sea turtles (Chelonia mydas) are an endangered species prone to a debilitating disease called fibropapillomatosis (FP). The aim of this study was to determine the influence of UV light on vitamin D levels and immune function in juvenile green sea turtles with FP. Phagocytosis, plasma vitamin D levels and viral load of ChHV5 were measured for FP- and FP+ turtles kept at the Gumbo Limbo Nature Center (GLNC) and for turtles caught at the St. Lucie power plant. Turtles kept at GLNC were...
Show moreGreen sea turtles (Chelonia mydas) are an endangered species prone to a debilitating disease called fibropapillomatosis (FP). The aim of this study was to determine the influence of UV light on vitamin D levels and immune function in juvenile green sea turtles with FP. Phagocytosis, plasma vitamin D levels and viral load of ChHV5 were measured for FP- and FP+ turtles kept at the Gumbo Limbo Nature Center (GLNC) and for turtles caught at the St. Lucie power plant. Turtles kept at GLNC were housed in tanks exposed to varying amounts of UV light. Turtles brought into GLNC had lower phagocytosis compared to turtles at the St. Lucie power plant. Individuals exposed to greater UV light had higher plasma vitamin D levels and a more successful recovery. The results of this project will provide rehabilitation facilities with a mechanism to improve the recovery of animals with this disease.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00013467
Subject Headings
Chelonia mydas, Green turtle--Diseases, Fibropapillomatosis, Ultraviolet radiation, Vitamin D
Format
Document (PDF)