Current Search: Genetics (x)
Pages
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Title
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Joint channel and data estimation: genetic algorithm based blind equalization.
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Creator
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Caimi, F. M., Wang, D., Harbor Branch Oceanographic Institute
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Date Issued
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1999
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PURL
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http://purl.flvc.org/FCLA/DT/3183717
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Subject Headings
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Genetic algorithms
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Format
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Document (PDF)
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Title
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Atom distance and interaction between DNA and acetylated histone tails.
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Creator
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Goordeen, Victoria, Snyder, Patricia Ann
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Date Issued
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2013-04-05
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PURL
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http://purl.flvc.org/fcla/dt/3361087
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Subject Headings
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Transcription, Genetic, Histones, DNA
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Format
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Document (PDF)
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Title
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Evolution of numeric constants in Genetic Programming.
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Creator
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Fernandez, Thomas, Florida Atlantic University, Evett, Matthew P.
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Abstract/Description
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Genetic Programming is an evolutionary technique for searching through the space of S-expressions for programs that represent optimal or acceptable solutions to a given problem. Genetic Programming often has difficulty in finding the appropriate numeric constants to use in leaf nodes of the S-expressions. This thesis describes the use of local search algorithms to search for numeric constants that will improve the S-expressions found by Genetic Programming. Three methods, Multi-Dimensional...
Show moreGenetic Programming is an evolutionary technique for searching through the space of S-expressions for programs that represent optimal or acceptable solutions to a given problem. Genetic Programming often has difficulty in finding the appropriate numeric constants to use in leaf nodes of the S-expressions. This thesis describes the use of local search algorithms to search for numeric constants that will improve the S-expressions found by Genetic Programming. Three methods, Multi-Dimensional Hill Climbing, Vector Hill Climbing, and Numeric Mutation are combined with Genetic Programming to create hybrid systems. The performance of these hybrid systems is analyzed and future directions for improving Genetic Programming with the use of hybrid systems are discussed.
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Date Issued
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1997
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PURL
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http://purl.flvc.org/fcla/dt/15493
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Subject Headings
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Genetic programming (Computer science)
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Format
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Document (PDF)
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Title
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Performance analysis of the genetic algorithm and its applications.
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Creator
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Liu, Xinggang., Florida Atlantic University, Zhuang, Hanqi, College of Engineering and Computer Science, Department of Computer and Electrical Engineering and Computer Science
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Abstract/Description
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Research and applications of genetic algorithms have become increasingly important in a wide variety of scientific fields. In this thesis, we present an empirical analysis of genetic algorithms in the function optimization area. As a focus of our research, a novel empirical analysis approach to various genetic algorithms is provided. The research starts from the survey of current trends in genetic algorithms, followed by exploring the characteristics of the simple genetic algorithm, the...
Show moreResearch and applications of genetic algorithms have become increasingly important in a wide variety of scientific fields. In this thesis, we present an empirical analysis of genetic algorithms in the function optimization area. As a focus of our research, a novel empirical analysis approach to various genetic algorithms is provided. The research starts from the survey of current trends in genetic algorithms, followed by exploring the characteristics of the simple genetic algorithm, the modified genetic algorithm and hybridized genetic algorithm. A number of typical function optimization problems are solved by these genetic algorithms. Ample empirical data associated with various modifications to the simple genetic algorithm is also provided. Results from this research can be used to assist practitioners in their applications of genetic algorithms.
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Date Issued
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1995
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PURL
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http://purl.flvc.org/fcla/dt/15210
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Subject Headings
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Genetic algorithms, Combinatorial optimization
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Format
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Document (PDF)
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Title
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Resistant or persistent reovirus infections: Of normal human embryonic lung fibroblast WI-38 cells.
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Creator
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Eukitis, Martine Marie., Florida Atlantic University, Roner, Michael R.
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Abstract/Description
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Reovirus is a common virus that usually affects children; this infection causes symptoms such as respiratory and or gastrointestinal aliments. Morbidity most often occurs in impoverished countries where supportive hospitalization is not available. In the U.S. and other established countries morbidity is not an issue. When WI-38 cells are infected with reovirus the infection is either resisted by the cells or a persistent latent infection occurs. In this study, gene expression was analyzed by...
Show moreReovirus is a common virus that usually affects children; this infection causes symptoms such as respiratory and or gastrointestinal aliments. Morbidity most often occurs in impoverished countries where supportive hospitalization is not available. In the U.S. and other established countries morbidity is not an issue. When WI-38 cells are infected with reovirus the infection is either resisted by the cells or a persistent latent infection occurs. In this study, gene expression was analyzed by comparing Reovirus-infected WI-38 cells with mock infected cells. P.R.O.M(TM) analysis was performed on RNA sent to Genka Biotechnology Inc. Bioinformatics was used to analyze the data. Reovirus infection of the WI-38 cells resulted in increased mRNA levels for a number of transcription regulatory genes, and possibly more significant, decreased mRNA levels for some very important regulatory genes. These changes may be responsible for establishing the antiviral replication environment observed in these normal cells.
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Date Issued
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2003
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PURL
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http://purl.flvc.org/fcla/dt/12991
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Subject Headings
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Reoviruses, Genetic regulation, Fibroblasts
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Format
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Document (PDF)
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Title
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GENOTYPIC SPERM SORTING: A less invasive “ART” to prevent Genetic Disorders in Newborns.
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Creator
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Adenmosun, Olumide O., Kumi-Diaka, James, Asghar, Waseem, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
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Abstract/Description
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Genetic disorders like Cystic Fibrosis (CF) and X-linked Diseases (XLD) are inherited by offspring from parents who are healthy carriers of the autosomal recessive or allosomal genes. About 10-million Americans are healthy carriers of a mutant cysticfibrosis gene (predominantly F508del) and about 4% of newborns are at risk of being born with an X-linked disease. The current clinically approved mitigation plan for preventing genetic disorders in newborns from “at-risk couples” is to consider...
Show moreGenetic disorders like Cystic Fibrosis (CF) and X-linked Diseases (XLD) are inherited by offspring from parents who are healthy carriers of the autosomal recessive or allosomal genes. About 10-million Americans are healthy carriers of a mutant cysticfibrosis gene (predominantly F508del) and about 4% of newborns are at risk of being born with an X-linked disease. The current clinically approved mitigation plan for preventing genetic disorders in newborns from “at-risk couples” is to consider Preimplantation Genetic Testing for Monogenetic diseases (PGT-M). PGT-M involves an invasive microsurgical procedure that requires the removal of cells from 3-5day old embryos. To minimize this invasiveness, we proposed a less invasive approach to prevent genetic disorders in newborns by genotypically sorting sperm cells which may be used for fertilization events (IUI/IVF/ICSI) with specially characterized antigens on the sperm surface membrane. For the disease models being adopted in our study – CF and XLD; we utilized certain monoclonal antibodies (mab) to target the H-Y male antigen and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein which are both selectively expressed on the sperm surface.
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Date Issued
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2021
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PURL
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http://purl.flvc.org/fau/fd/FA00013805
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Subject Headings
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Genetic disorders--Prevention, Genetic Testing, Reproductive technology, Cystic fibrosis
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Format
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Document (PDF)
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Title
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Characterization of Methionine Sulfoxide Reductases A and Bs from Tobacco Plant.
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Creator
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Ding, Di, Zhang, Xing-Hai, Florida Atlantic University
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Abstract/Description
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One methionine sulfoxide reductase A (TMSRA) and two methionine sulfoxide reductase Bs (TMSRB 1 and TMSRB2) were isolated from tobacco plants. TMSRA showed specificity for the reduction of Met-(S)-SO and both TMSRBs were specific for the reduction of Met-(R)-SO. TMSRA was the cytosolic form and both TMSRBs were plastid forms based on sequence comparison and expression tests. TMSRA and TMSRB2 could use either thioredoxin (TRX) or dithiothreitol (DTT) as reducing system, while TMSRB 1 showed...
Show moreOne methionine sulfoxide reductase A (TMSRA) and two methionine sulfoxide reductase Bs (TMSRB 1 and TMSRB2) were isolated from tobacco plants. TMSRA showed specificity for the reduction of Met-(S)-SO and both TMSRBs were specific for the reduction of Met-(R)-SO. TMSRA was the cytosolic form and both TMSRBs were plastid forms based on sequence comparison and expression tests. TMSRA and TMSRB2 could use either thioredoxin (TRX) or dithiothreitol (DTT) as reducing system, while TMSRB 1 showed little activity with TRX but much more activity with DTT, which was similar to the mitochondrial MSRB2 from mammals. Ferredoxin (FD) is not the reducing system for Msrs, but might reflect the redox status in the cell and control the activity of Msrs indirectly.
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Date Issued
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2006
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PURL
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http://purl.flvc.org/fau/fd/FA00000746
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Subject Headings
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Proteins--Chemical modification, Genetic regulation, Plant genetic engineering, Antioxidants
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Format
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Document (PDF)
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Title
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Progress towards genetic engineering of an EMF-responsive plasmid in yeast.
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Creator
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Crenshaw, Karin Ann., Florida Atlantic University, Binninger, David
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Abstract/Description
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Despite the many epidemiological studies which have shown some effects of EMF on biological systems, there has yet to be any data that indicates the molecular mechanisms by which this effect takes place. My goal was to genetically engineer a yeast strain that would have a clear biological effect to the EMF's. The strategy involved using a yeast strain which requires histone function from a plasmid, and the plasmid construct that has a Gal1 promoter controlling the histone function. The...
Show moreDespite the many epidemiological studies which have shown some effects of EMF on biological systems, there has yet to be any data that indicates the molecular mechanisms by which this effect takes place. My goal was to genetically engineer a yeast strain that would have a clear biological effect to the EMF's. The strategy involved using a yeast strain which requires histone function from a plasmid, and the plasmid construct that has a Gal1 promoter controlling the histone function. The plasmid construct could then be engineered to contain a promoter sequence for a known EMF-repressed gene in yeast, which would control the histone production. Without a functional histone gene, the cells will die, and the effects will be easily visualized. Although the genetic screening for the desired transformants appeared to work, the molecular analysis of those transformants did not show the promoter insertion. There are a few possible reasons for why this happened, including possible reversions from one of the original mutations of the chromosomal histone H4 genes, or the mutation of the Gal1 promoter which would no longer repress the histone H4 gene and allow the cells to grow on glucose.
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Date Issued
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1998
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PURL
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http://purl.flvc.org/fcla/dt/15572
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Subject Headings
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Electromagnetism--Physiological effect, Genetic engineering, Plasmids--Genetics
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Format
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Document (PDF)
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Title
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Novel Techniques in Genetic Programming.
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Creator
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Fernandez, Thomas, Furht, Borko, Florida Atlantic University, College of Engineering and Computer Science, Department of Computer and Electrical Engineering and Computer Science
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Abstract/Description
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Three major problems make Genetic Programming unfeasible or impractical for real world problems. The first is the excessive time complexity.In nature the evolutionary process can take millions of years, a time frame that is clearly not acceptable for the solution of problems on a computer. In order to apply Genetic Programming to real world problems, it is essential that its efficiency be improved. The second is called overfitting (where results are inaccurate outside the training data). In a...
Show moreThree major problems make Genetic Programming unfeasible or impractical for real world problems. The first is the excessive time complexity.In nature the evolutionary process can take millions of years, a time frame that is clearly not acceptable for the solution of problems on a computer. In order to apply Genetic Programming to real world problems, it is essential that its efficiency be improved. The second is called overfitting (where results are inaccurate outside the training data). In a paper[36] for the Federal Reserve Bank, authors Neely and Weller state “a perennial problem with using flexible, powerful search procedures like Genetic Programming is overfitting, the finding of spurious patterns in the data. Given the well-documented tendency for the genetic program to overfit the data it is necessary to design procedures to mitigate this.” The third is the difficulty of determining optimal control parameters for the Genetic Programming process. Control parameters control the evolutionary process. They include settings such as, the size of the population and the number of generations to be run. In his book[45], Banzhaf describes this problem, “The bad news is that Genetic Programming is a young field and the effect of using various combinations of parameters is just beginning to be explored.” We address these problems by implementing and testing a number of novel techniques and improvements to the Genetic Programming process. We conduct experiments using data sets of various degrees of difficulty to demonstrate success with a high degree of statistical confidence.
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Date Issued
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2006
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PURL
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http://purl.flvc.org/fau/fd/FA00012570
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Subject Headings
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Evolutionary programming (Computer science), Genetic algorithms, Genetic programming (Computer science)
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Format
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Document (PDF)
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Title
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Polymorphism and selection at exon 2 of the class II beta chain of the major histocompatibility complex in Forpus passerinus.
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Creator
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Walbroehl, Jaclyn M., Florida Atlantic University, Hughes, Colin
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Abstract/Description
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Female mate choice has been proposed to be a major force acting to maintain the polymorphism of the MHC, the most genetically variable genes known. I genotyped seventy-two individuals from a free-living population of the parrot, Forpus passerinus, in order to determine whether disassortative mating is the mode of selection acting at this locus. Both the high rate of nonsynonymous amino acid changes at the peptide binding regions of exon 2 of the class II beta gene and the unprecedented number...
Show moreFemale mate choice has been proposed to be a major force acting to maintain the polymorphism of the MHC, the most genetically variable genes known. I genotyped seventy-two individuals from a free-living population of the parrot, Forpus passerinus, in order to determine whether disassortative mating is the mode of selection acting at this locus. Both the high rate of nonsynonymous amino acid changes at the peptide binding regions of exon 2 of the class II beta gene and the unprecedented number of alleles found in this population provided strong evidence for the operation of selection. Despite this, a chi-square test revealed no evidence of disassortative mating for this sample, X2=0.569, n.s. I propose that natural selection, not sexual selection, must be operating at this locus to maintain the degree of variation found in 270 base-pairs of this gene.
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Date Issued
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2006
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PURL
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http://purl.flvc.org/fcla/dt/13405
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Subject Headings
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Immunogenetics, Genetic polymorphisms, Major histocompatibility complex--Genetic aspects
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Format
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Document (PDF)
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Title
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GENETIC SCREENS IDENTIFY NOVEL REGULATORS OF SLEEP AND METABOLISM IN DROSOPHILA MELANOGASTER.
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Creator
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Murakami, Kazuma N., Keene, Alex C., Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
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Abstract/Description
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Proper regulation of sleep and metabolism are critical to the survival of all organisms. In humans, dysregulation of sleep is linked to metabolic syndrome, including hypertension, hyperglycemia and hyperlipidemia. However, the mechanisms regulating interactions between sleep and metabolism are poorly understood. Although the fruit fly, Drosophila melanogaster, bears little anatomical resemblance to humans, it shares similar genetics essential in understanding normal development and disease in...
Show moreProper regulation of sleep and metabolism are critical to the survival of all organisms. In humans, dysregulation of sleep is linked to metabolic syndrome, including hypertension, hyperglycemia and hyperlipidemia. However, the mechanisms regulating interactions between sleep and metabolism are poorly understood. Although the fruit fly, Drosophila melanogaster, bears little anatomical resemblance to humans, it shares similar genetics essential in understanding normal development and disease in humans. From humans to flies, many disease-related genes and pathways are highly conserved, rendering the fruit fly ideal to understanding the interactions between sleep and metabolism. Therefore, using the fruit fly provides a framework for understanding how genes function between sleep and metabolism. During starvation, both humans and rats reduce their sleep. Similarly, previous studies have shown that fruit flies also suppress sleep to forage for food, further showing that sleep and metabolism are intricately tied to one another and that they are highly conserved across species. To further explore the interactions between sleep and metabolism, I have conducted multiple genetic screens to identify novel regulators of sleep-metabolism interactions. These experiments led to the identification of the mRNA binding protein translin (trsn) as being required for starvation-induced sleep suppression. A second screen that targeted metabolic genes from a genome-wide association study identified the ion channel accessory protein uncoordinated 79 (unc79) as a critical regulator of both sleep duration and starvation resistance. The genes function in different regions of the brain and suggest complex neural circuitry is likely to underlie regulation of sleep metabolism interactions. Taken together, a mechanistic understanding of how different genes function to regulate sleep in flies will further our understanding of how sleep and metabolism is regulated in humans.
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Date Issued
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2021
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PURL
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http://purl.flvc.org/fau/fd/FA00013722
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Subject Headings
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Drosophila melanogaster, Sleep, Genetic screening
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Format
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Document (PDF)
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Title
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Is there an error correcting code in the base sequence in DNA?.
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Creator
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Liebovitch, Larry S., Levine, Leo, Tao, Yi, Todorov, Angelo T.
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Date Issued
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1996-09
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PURL
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http://purl.flvc.org/fau/165441
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Subject Headings
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Biophysics--Research, DNA, Genetics, DNA Repair--genetics, DNA--Analysis--Mathematical models, Genetic code
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Format
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Document (PDF)
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Title
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Cytogenetic of chromosomal synteny evaluation: bioinformatic applications towards screening of chromosomal aberrations/ genetic disorder.
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Creator
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Sharma, Sandhya, Neelakanta, Perambur S., Florida Atlantic University, College of Engineering and Computer Science, Department of Computer and Electrical Engineering and Computer Science
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Abstract/Description
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The research efforts refer to tracking homologus loci in the chromosomes of a pair of a species. The purpose is to infer the extent of maximum syntenic correlation when an exhaustive set of orthologs of the species are searched. Relevant bioinformatic analyses use comparative mapping of conserved synteny via Oxford grid. In medical diagnostic efforts, deducing such synteny correlation can help screening chromosomal aberration in genetic disorder pathology. Objectively, the present study...
Show moreThe research efforts refer to tracking homologus loci in the chromosomes of a pair of a species. The purpose is to infer the extent of maximum syntenic correlation when an exhaustive set of orthologs of the species are searched. Relevant bioinformatic analyses use comparative mapping of conserved synteny via Oxford grid. In medical diagnostic efforts, deducing such synteny correlation can help screening chromosomal aberration in genetic disorder pathology. Objectively, the present study addresses: (i) Cytogenetic framework of syntenic correlation and, (ii) applying information-theoretics to determine entropy-dictated synteny across an exhaustive set of orthologs of the test pairs of species.
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Date Issued
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2014
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PURL
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http://purl.flvc.org/fau/fd/FA00004331, http://purl.flvc.org/fau/fd/FA00004331
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Subject Headings
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Cytogenetics, Genetic screening, Human chromosome abnormalities, Medical genetics, Molecular biology, Molecular diagnosis, Molecular genetics, Mutation (Biology)
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Format
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Document (PDF)
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Title
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Cells and cocktails: antioxidants rescue carcinogen induced mitotic defects in both chromosomally stable and unstable cells.
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Creator
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Griffin, Isabel Sloan., Harriet L. Wilkes Honors College
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Abstract/Description
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Tumor cells are characterized by an increase in genomic instability, brought about by both chromosomal rearrangement and chromosomal instability. Both of these broad changes can be induced by exposure to carcinogens. During mitosis, cells can exhibit early and late lagging chromosomes, multipolar spindles or anaphase bridges, all of which contribute to genomic rearrantement. We have studied the link between exposure to carcinogen and prevalence of mitotic defect in both chromosomally stable...
Show moreTumor cells are characterized by an increase in genomic instability, brought about by both chromosomal rearrangement and chromosomal instability. Both of these broad changes can be induced by exposure to carcinogens. During mitosis, cells can exhibit early and late lagging chromosomes, multipolar spindles or anaphase bridges, all of which contribute to genomic rearrantement. We have studied the link between exposure to carcinogen and prevalence of mitotic defect in both chromosomally stable and unstable cell lines as well as ecamined the restorative effects of antioxidants in preventing mitotic defects. We have exposed MES-SA uterine cancer cells to vinyl chloride followed by exposure to an antioxidant : ascorbic acid, B-carotene, or lycopene. Treated cells were then scored for the prevalence of mitotic defects within the population and compared to controls. We have also investigated whether pre-treatment with the antioxidants will weaken the effects of carcinogen exposure in these cell lines.
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Date Issued
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2012
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PURL
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http://purl.flvc.org/FAU/3359304
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Subject Headings
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Cellular signal transduction, Cell differentiation, Medical genetics, Cancer, Genetic aspects, Antioxidants, Therapeutic use, Cancer, Chemoprevention, Apoptosis, Molecular aspects, Genetic regulation
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Format
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Document (PDF)
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Title
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Significance of macroalgal polymorphism: intraspecific tests of the functional-form model.
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Creator
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Hanisak, M. Dennis, Littler, Mark M., Littler, Diane S.
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Date Issued
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1988
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PURL
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http://purl.flvc.org/FCLA/DT/3333114
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Subject Headings
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Algal communities, Red algae, Polymorphism, Genetic, Gracilaria
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Format
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Document (PDF)
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Title
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Characterization of genetic markers for in vitro cell line identification of the marine sponge, Axinella corrugata.
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Creator
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Lopez, Jose V., Peterson, C. L., Willoughby, Robin, Wright, Amy E., Enright, E., Zoladz, S., Pomponi, Shirley A.
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Date Issued
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2002
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PURL
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http://purl.flvc.org/FCLA/DT/3355156
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Subject Headings
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Sponges--Research, Marine invertebrates, Genetic markers
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Format
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Document (PDF)
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Title
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Bioinformatic analysis of viral genomic sequences and concepts of genome-specific national vaccine design.
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Creator
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Chatterjee, Sharmistha P., College of Engineering and Computer Science, Department of Computer and Electrical Engineering and Computer Science
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Abstract/Description
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This research is concerned with analyzing a set of viral genomes to elucidate the underlying characteristics and determine the information-theoretic aspects of the genomic signatures. The goal of this study thereof, is tailored to address the following: (i) Reviewing various methods available to deduce the features and characteristics of genomic sequences of organisms in general, and particularly focusing on the genomes pertinent to viruses; (ii) applying the concepts of information...
Show moreThis research is concerned with analyzing a set of viral genomes to elucidate the underlying characteristics and determine the information-theoretic aspects of the genomic signatures. The goal of this study thereof, is tailored to address the following: (i) Reviewing various methods available to deduce the features and characteristics of genomic sequences of organisms in general, and particularly focusing on the genomes pertinent to viruses; (ii) applying the concepts of information-theoretics (entropy principles) to analyze genomic sequences; (iii) envisaging various aspects of biothermodynamic energetics so as to determine the framework and architecture that decide the stability and patterns of the subsequences in a genome; (iv) evaluating the genomic details using spectral-domain techniques; (v) studying fuzzy considerations to ascertain the overlapping details in genomic sequences; (vi) determining the common subsequences among various strains of a virus by logistically regressing the data obtained via entropic, energetics and spectral-domain exercises; (vii) differentiating informational profiles of coding and non-coding regions in a DNA sequence to locate aberrant (cryptic) attributes evolved as a result of mutational changes and (viii) finding the signatures of CDS of genomes of viral strains toward rationally conceiving plausible designs of vaccines. Commensurate with the topics indicated above, necessary simulations are proposed and computational exercises are performed (with MatLabTM R2009b and other software as needed). Extensive data gathered from open-literature are used thereof and, simulation results are verified. Lastly, results are discussed, inferences are made and open-questions are identified for future research.
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Date Issued
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2013
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PURL
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http://purl.flvc.org/FAU/3360772
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Subject Headings
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Genetic engineering, Bioinformatics, Genomics, DNA microarrays, Proteomics
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Format
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Document (PDF)
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Title
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DIRECT AND INDIRECT EFFECTS FROM AGGRESSION TO INTERNALIZING SYMPTOMS: A GENETICALLY CONTROLLED STUDY.
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Creator
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Valdés, Olivia, Laursen, Brett, Florida Atlantic University, Department of Psychology, Charles E. Schmidt College of Science
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Abstract/Description
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Behavioral difficulties in the early school years pose a risk to psychosocial functioning. The failure model suggests that peer rejection explains longitudinal associations between aggression and internalizing symptoms. The model postulates that aggression leads to increases in peer rejection, which, in turn, contributes to internalizing symptoms. This study tests pathways posited by the failure model, examining direct and indirect longitudinal effects. Direct effects models examined...
Show moreBehavioral difficulties in the early school years pose a risk to psychosocial functioning. The failure model suggests that peer rejection explains longitudinal associations between aggression and internalizing symptoms. The model postulates that aggression leads to increases in peer rejection, which, in turn, contributes to internalizing symptoms. This study tests pathways posited by the failure model, examining direct and indirect longitudinal effects. Direct effects models examined associations between reactive aggression and internalizing problems, reactive aggression and peer rejection, and peer rejection and internalizing symptoms. A mediation model examined the indirect effect of reactive aggression to internalizing symptoms, via peer rejection. Because distinct components of the failure model are presumed to share genetic influences, removing potential genetic contributions is important when examining the environmental influences over developmental pathways posited by the model. To this end, longitudinal tests were conducted with traditional (non-genetically controlled) and MZ twin difference (genetically controlled) designs. The latter disentangled nonshared environment effects from those for genetic factors from environmental factors.
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Date Issued
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2020
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PURL
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http://purl.flvc.org/fau/fd/FA00013578
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Subject Headings
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Behavior disorders in children, Aggression, Behavior genetics
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Format
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Document (PDF)
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Title
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EFFECT OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE (MNNG) ON DNA OF CULTURED RAT HEPATOMA CELLS.
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Creator
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JHABVALA, PERSEUS, Florida Atlantic University, Stein, Abraham, Charles E. Schmidt College of Science, Department of Biological Sciences
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Abstract/Description
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The objective of this study was to elucidate the interaction of the carcinogen MNNG with nuclear DNA of Rat Hepatoma cells. The effect of a range of MNNG concentrations on RH cell DNA was studied by an analysis of the DNA fragments obtained in linear alkaline sucrose gradients. A macromolecular analysis of the sedimentation profile for 0.06 mM MNNG (Experiment I), and 0.1 mM MNNG (Experiment III), suggested that the system was paucidisperse and contained at least three components. The major...
Show moreThe objective of this study was to elucidate the interaction of the carcinogen MNNG with nuclear DNA of Rat Hepatoma cells. The effect of a range of MNNG concentrations on RH cell DNA was studied by an analysis of the DNA fragments obtained in linear alkaline sucrose gradients. A macromolecular analysis of the sedimentation profile for 0.06 mM MNNG (Experiment I), and 0.1 mM MNNG (Experiment III), suggested that the system was paucidisperse and contained at least three components. The major component Max 1 has a molecular weight comparable to that known for the mammalian replicon. Max 2 has a molecular weight twice that of Max 1 and Max 3 has a molecular weight half that of Max 1. The size of the replicon is comparable to that obtained by others. Inferences were drawn regarding the structure of chromatin and the role of the distribution of sites hypersensitive to methylation with respect to the oncogenes.
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Date Issued
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1985
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PURL
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http://purl.flvc.org/fcla/dt/14260
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Subject Headings
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Carcinogenicity testing, Cancer--Genetic aspects, DNA
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Format
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Document (PDF)
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Title
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Optimal planning of robot calibration experiments by genetic algorithms.
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Creator
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Huang, Weizhen., Florida Atlantic University, Wu, Jie
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Abstract/Description
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In this thesis work, techniques developed in the science of genetic computing is applied to solve the problem of planning a robot calibration experiment. Robot calibration is a process by the robot accuracy is enhanced through modification of its control software. The selection of robot measurement configurations is an important element in successfully completing a robot calibration experiment. A classical genetic algorithm is first customized for a type of robot measurement configuration...
Show moreIn this thesis work, techniques developed in the science of genetic computing is applied to solve the problem of planning a robot calibration experiment. Robot calibration is a process by the robot accuracy is enhanced through modification of its control software. The selection of robot measurement configurations is an important element in successfully completing a robot calibration experiment. A classical genetic algorithm is first customized for a type of robot measurement configuration selection problem in which the robot workspace constraints are defined in terms of robot joint limits. The genetic parameters are tuned in a systematic way to greatly enhance the performance of the algorithm. A recruit-oriented genetic algorithm is then proposed, together with new genetic operators. Examples are also given to illustrate the concepts of this new genetic algorithm. This new algorithm is aimed at solving another type of configuration selection problem, in which not all points in the robot workspace are measurable by an external measuring device. Extensive simulation studies are conducted for both classical and recruit-oriented genetic algorithms, to examine the effectiveness of these algorithms.
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Date Issued
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1995
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PURL
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http://purl.flvc.org/fcla/dt/15186
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Subject Headings
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Genetic algorithms, Robots--Calibration, Combinatorial optimization
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Format
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Document (PDF)
Pages