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Title: “EVERY HUMAN IS PSYCHEDELIC” AN ANALYSIS OF CONTEMPORARY PSYCHEDELIC DRUG USE AND SUBCULTURE.
Creator: Taylor, H. J., Lewin, Philip, Florida Atlantic University, Department of Sociology, Dorothy F. Schmidt College of Arts and Letters
Abstract/Description: The 21st Century is seeing an unprecedented wave of psychedelic drug research after decades of stagnancy. Despite this revival, there has been little research or interest in the current revival of psychedelic subculture or the attitudes of psychedelic users today—from here referred to as “psychedelia.” This qualitative study of 19 self-described psychedelic users/psychedelia members probes their intimate experiences with psychedelic drugs, their involvement in the broader subculture, and...
Show moreThe 21st Century is seeing an unprecedented wave of psychedelic drug research after decades of stagnancy. Despite this revival, there has been little research or interest in the current revival of psychedelic subculture or the attitudes of psychedelic users today—from here referred to as “psychedelia.” This qualitative study of 19 self-described psychedelic users/psychedelia members probes their intimate experiences with psychedelic drugs, their involvement in the broader subculture, and their political and social beliefs. By analyzing the subculture through post-subcultural theory, this study examines the state of psychedelic subculture today, its participants, and members beliefs in relation to drugs, politics, and society. Findings show psychedelia exists as a loose subculture, yet has several parallels to the hippies demographically and politically. Second, psychedelia members share several values such as openness, compassion, and caring for others. Third, despite their pessimism towards America’s future, interviewees engage in everyday activism to help disenfranchised groups.
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Date Issued: 2022
PURL: http://purl.flvc.org/fau/fd/FA00014105
Subject Headings: Psychedelic drugs, Hallucinogenic drugs, Subculture
Format: Document (PDF)

Title: Assessing organizational effectiveness: The impact of drug court processes on offender behavior change.
Creator: Senjo, Scott Robert, Florida Atlantic University, Leip, Leslie A.
Abstract/Description: The issue of drugs and crime maintains a high rank among the complexities which confront the American system of criminal justice. The "treatment drug court" represents an innovative response by policymakers to address drug use and its relationship to criminal activity. Treatment drug court is a court-monitored drug treatment program for people arrested for felony use or possession of illegal drugs. Many defendants select the drug court option rather than probation because most drug courts...
Show moreThe issue of drugs and crime maintains a high rank among the complexities which confront the American system of criminal justice. The "treatment drug court" represents an innovative response by policymakers to address drug use and its relationship to criminal activity. Treatment drug court is a court-monitored drug treatment program for people arrested for felony use or possession of illegal drugs. Many defendants select the drug court option rather than probation because most drug courts will dismiss the original felony charges upon successful completion of the court's drug treatment program. This dissertation is a focus on the unique "collaborative support" developed and implemented by the officers in the drug court to address the problem of drugs and crime. Using a descriptive case study and an observational design, a cohort of 100 drug court participants were observed during their participation in the intensive drug court treatment program, including appearances before the drug court itself for periodic monitoring by the court. Utilizing a comprehensive data collection scheme, statistical analyses were conducted to identify the features of the drug court program which had the greatest influence on achieving the drug court's goals. Research findings indicate that the court is an effective organization based on the collaborative support implemented on behalf of the offenders in the program. With the combination of progressive sanctions and collaborative support for offenders the court is found to make a pointed effort to address drug use. The court seeks to permanently alter the root of the problem, the need for drugs, rather than passively dealing with symptoms of the problem. While other criminal courts are laden with drug addicted defendants who revolve in and out of the criminal justice system, the drug court engages in a constructive form of problem solving, seeking to resolve, rather than merely process cases.
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Date Issued: 1998
PURL: http://purl.flvc.org/fcla/dt/12569
Subject Headings: Drug courts, Drug abuse--Treatment, Drug abuse and crime
Format: Document (PDF)

Title: Attention deficit caused by MDMA ('ecstasy').
Creator: Rudacille, Mary C., Tao, Rui
Date Issued: 2013-04-05
PURL: http://purl.flvc.org/fcla/dt/3361175
Subject Headings: Ecstasy (Drug), MDMA (Drug), Attention deficit disorder
Format: Document (PDF)

Title: Cognitive performance predicted by recreational drug use.
Creator: Paz, Andres L., Rosselli, Monica, Graduate College
Date Issued: 2013-04-12
PURL: http://purl.flvc.org/fcla/dt/3361952
Subject Headings: Drug abuse, Cognition
Format: Document (PDF)

Title: Characterization of Disulfide Constrained Natural Peptides.
Creator: Hoggard, Mickelene F., Cudic, Mare, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: The use of peptide drugs has gained popularity recently. Peptides are attractive drug targets due to their high specificity and potency towards their biological targets. A drawback for peptide drugs is a lack of stability for oral delivery. Two classes of disulfide-rich peptides, conotoxins and cyclotides, have been shown to have higher stability than linear peptides thanks to their disulfide connectivity. Conotoxins are present in the venom of cone snails, a carnivorous marine mollusk that...
Show moreThe use of peptide drugs has gained popularity recently. Peptides are attractive drug targets due to their high specificity and potency towards their biological targets. A drawback for peptide drugs is a lack of stability for oral delivery. Two classes of disulfide-rich peptides, conotoxins and cyclotides, have been shown to have higher stability than linear peptides thanks to their disulfide connectivity. Conotoxins are present in the venom of cone snails, a carnivorous marine mollusk that preys upon fish, worms, or other mollusks. Conotoxins are promising drugs leads with great prospects in the treatment of diseases and disorders such as chronic pain, multiple sclerosis and Parkinson’s and Alzheimer’s diseases. Cyclotides, which are cyclic cysteine knot containing peptides, isolated from the Violaceae (violet), Rubiaceae (coffee), and Cucurbitaceae (cucurbit) families and they have a wide range of biological activities, such as anti-HIV, uterotonic, and antimicrobial. P-superfamily framework IX conotoxins (C-C- C-CXC- C) contain the same cysteine framework, homologous sequences, and similar 3D structures to cyclotides. The knot containing conotoxins have been identified in several Conus species, but this work focuses on those from Conus brunneus, Conus purpurascens, and Conus gloriamaris. The cysteine knot motif of cyclotides and P-superfamily conotoxins is characterized by a cyclic backbone and six-conserved cysteine residues that form the three-disulfide bridges of the “knot”. This motif provides cyclotides and conotoxins with superior stability against thermal, chemical, and enzymatic degradation; marking them as potential frameworks for peptide drug delivery. Presented are details on the isolation of conotoxins and cyclotides, from Viola tricolor, and the characterization of their activity in the well-characterized Drosophila melanogaster giant fiber system (GFS) neuronal circuit, which contains GAP, acetylcholine, and glutamate synapses. The transcriptomes of two Conus brunneus specimens were assembled and mined for P-superfamily framework IX conotoxins. Eleven mature P-superfamily framework IX conotoxins were identified in the crude venom.
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Date Issued: 2018
PURL: http://purl.flvc.org/fau/fd/FA00005955
Subject Headings: Peptide drugs, Cyclotides, Conotoxins
Format: Document (PDF)

Title: Contingent suppression of tolerance to the "anorexigenic" effect of haloperidol.
Creator: Thompson, Garrie Burton, III, Florida Atlantic University
Abstract/Description: Two experiments were performed to determine whether tolerance to the "anorexigenic" effect of haloperidol is contingent on access to food in the drugged state. In the first experiment groups of rats were given injections of haloperidol (2.5 or 5 mg/kg) either before or after a 30-min drinking session for 53 days. Control groups were given saline injections. On Day 54 all groups were given the drug before milk access to determine the level of tolerance. Rats which had received the drug after...
Show moreTwo experiments were performed to determine whether tolerance to the "anorexigenic" effect of haloperidol is contingent on access to food in the drugged state. In the first experiment groups of rats were given injections of haloperidol (2.5 or 5 mg/kg) either before or after a 30-min drinking session for 53 days. Control groups were given saline injections. On Day 54 all groups were given the drug before milk access to determine the level of tolerance. Rats which had received the drug after milk were found to be more tolerant than rats given the drug chronically before milk on Day 54. In the second experiment the length of drug administration was shortened to 14 days. Findings suggested that rats which received chronic post-test injections of haloperidol continued to develop tolerance with repeated injections of the drug, while the development of such tolerance was suppressed after Day 15 in rats given repeated pre-test injections of the drug. (Abstract shortened with permission of author.)
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Date Issued: 1987
PURL: http://purl.flvc.org/fcla/dt/14425
Subject Headings: Drug tolerance, Neuropsychopharmacology
Format: Document (PDF)

Title: The synthesis of chitosan-cis-DDP derivative.
Creator: Francis, Ann-Marie, Florida Atlantic University, Louda, Deborah W., Carraher, Charles E.
Abstract/Description: The formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity...
Show moreThe formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity of cis-DDP but produce fewer toxic side effects. Structural characterization involved infrared spectroscopy, mass spectroscopy, EDAX analytical methods. Products were also analyzed using light scattering photometry, elemental analysis and solubility studies. Additionally, the biological activity of water-soluble products was tested against selected cell lines.
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Date Issued: 1999
PURL: http://purl.flvc.org/fcla/dt/15699
Subject Headings: Chitosan, Polymeric drugs
Format: Document (PDF)

Title: Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia.
Creator: Hughes, Katherine M., Florida Atlantic University, Wolgin, David L.
Abstract/Description: The purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was...
Show moreThe purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was available. After a 4 wk drug withdrawal period, both groups lost tolerance and displayed more intense stereotypy than they had prior to drug withdrawal. Therefore, sensitization of stereotypy did not retard the development of tolerance. However, the loss of tolerance following drug withdrawal may have been due to the development of more intense stereotypy and/or the "unlearning" of previously acquired strategies for suppressing stereotypy.
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Date Issued: 1996
PURL: http://purl.flvc.org/fcla/dt/15287
Subject Headings: Drug tolerance, Drugs--Physiological effect, Amphetamines--Physiological effect
Format: Document (PDF)

Title: Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine induced hypophagia.
Creator: Kinney, Gene G., Florida Atlantic University, Wolgin, David L., Charles E. Schmidt College of Science, Department of Psychology
Abstract/Description: It was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is,...
Show moreIt was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is, sensitized animals were not impaired on milk intake, whereas nonsensitized animals became more sensitive to the hypophagic effect of amphetamine. Further, it was found that animals sensitized to the stereotyped behavioral effects of the drug developed tolerance to this effect, and this tolerance was found to occur both in the presence and absence of milk.
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Date Issued: 1992
PURL: http://purl.flvc.org/fcla/dt/14792
Subject Headings: Drug tolerance, Drugs--Physiological effect, Amphetamines--Physiological effect
Format: Document (PDF)

Title: PARTICIPANTS’ RECOVERY IN DRUG COURT.
Creator: Cuevas, Selina F., Guastaferro, Wendy P., Florida Atlantic University, School of Criminology and Criminal Justice, College of Social Work and Criminal Justice
Abstract/Description: This study examined drug court participants’ lived experiences with addiction and recovery from the southern part of the U.S.. Results of the study answered the following: how do drug court participants discuss their lived experiences with each of the following key recovery concepts: accountability, unmanageability, and relapse? Recorded focus groups explored the a priori recovery concepts. Focus groups were used for identifying themes, and how participants apply these themes to recovery....
Show moreThis study examined drug court participants’ lived experiences with addiction and recovery from the southern part of the U.S.. Results of the study answered the following: how do drug court participants discuss their lived experiences with each of the following key recovery concepts: accountability, unmanageability, and relapse? Recorded focus groups explored the a priori recovery concepts. Focus groups were used for identifying themes, and how participants apply these themes to recovery. Audio files were transcribed and coded using NVivo 1.5 software for data analysis. The findings also present emergent themes which allowed participants to articulate their lived experiences as more than a disease, but as a recovery process. Drug court programs must prioritize the curriculum to reflect on the experiences depicted to effectively aid in recovery. Lastly, conducting the same focus groups throughout the duration of the program may be beneficial to properly track progress.
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Date Issued: 2022
PURL: http://purl.flvc.org/fau/fd/FA00013911
Subject Headings: Drug courts, Civil commitment of drug addicts, Recovery
Format: Document (PDF)

Title: Drugs, war and immigration: a shared conflict.
Creator: Leal, Alberto, Pritchard, Anita
Date Issued: 2013-04-05
PURL: http://purl.flvc.org/fcla/dt/3361113
Subject Headings: Drugs & conflict, Immigration, Political science
Format: Document (PDF)

Title: The effects of 3.4 methylenedioxymethamphetamine (MDMA) on mnemonic and executive measures and serotonergic neurotoxicity using interspecies effects scaling.
Creator: Linley, Stephanie Brooke., Charles E. Schmidt College of Science, Department of Psychology
Abstract/Description: 3,4-methlenedioxymethamphetamine (MDMA), the main constituent of Ecstasy, is a ring-substituted amphetamine commonly abused in recreational users. High doses of MDMA determined by allometric scaling produce serotonin (5-HT) axon deneveration. Studies suggest that this interspecies scaling does not reflect human use. An 'effects' scale comparing similar behavioral and physiological effects between species has been postulated as more accurate for translational studies. Experiment 1 examined the...
Show more3,4-methlenedioxymethamphetamine (MDMA), the main constituent of Ecstasy, is a ring-substituted amphetamine commonly abused in recreational users. High doses of MDMA determined by allometric scaling produce serotonin (5-HT) axon deneveration. Studies suggest that this interspecies scaling does not reflect human use. An 'effects' scale comparing similar behavioral and physiological effects between species has been postulated as more accurate for translational studies. Experiment 1 examined the effects of MDMA on serotonergic forebrain innervation using immunohistochemical labeling targeting the serotonin transporter protein (SERT). Experiments 2 and 3 examined low and high doses of MDMA on spatial memory, prefrontal functioning, and serotonergic neurotoxicity using 'effects' scaling. Long Evans rats were given MDMA regimens of: chronic low dose (daily injections of 1.5 mg/kg for 10 days); binge low dose (2 days of 4 x 1.5 mg/kg spaced 2 hours apart), binge high dose (2 x 7.5 mg/kg sp aced 2 hours apart). Acquisition, retention, and spatial reversal (SR) were measured in a water maze task. A 2.0 mg/kg MDMA drug challenge was then given prior to a serial spatial reversal (SSR) task to assess performance while under the effect of the drug. Attentional set shifting and behavioral flexibility were assessed in an intradimensional extradimensionl (IED) task using odor/texture discriminations. MDMA chronic and binge low doses did not impair water maze or IED performance and produced no reductions in SERT expression. MDMA binge high dose resulted in significant reductions of SERT density in the prefrontal cortex, striatum, cortical mantle, hippocampus, amygdala, and many thalamic nuclei. Despite prominent 5-HT denervation, water maze performance was unaffected. Selective impairment in behavioral flexibility on the IED test was found., This suggests that low doses of MDMA do not produce long-term deleterious effects. But, high doses of MDMA taken in 'binges' produces widespread loss of forebrain SERT fiber innervation and significant impairments in reversal learning, while leaving attentional set shifting and spatial navigation unscathed.
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Date Issued: 2011
PURL: http://purl.flvc.org/FAU/3171679
Subject Headings: MDMA (Drug), Ecstasy (Drug), Psychological effect, Psychopharmacology, Methamphetamine abuse, Brain, Effect of drugs on, Psychotropic drugs, Side effects
Format: Document (PDF)

Title: CAENORHABDITIS ELEGANS MMP STRAINS AND THEIR POTENTIAL DRIVING FORCE IN ANTIEPILEPTIC DRUG RESEARCH.
Creator: Sanchez, Christina Laura, Dawson-Scully, Ken, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
Abstract/Description: Over 70 million people worldwide suffer from epilepsy, with 90% of those cases taking place in developing countries (Singh & Trevick, 2016). Epilepsy can be defined as at least two unprovoked seizures occurring more than 24 hours apart, one unprovoked seizure with at least 60% chance of another seizure occurring within the next 10 years, or a diagnosis of epilepsy syndrome (Fisher et al., 2005). Varying physiological, molecular, genetic, and environmental factors can contribute to epileptic...
Show moreOver 70 million people worldwide suffer from epilepsy, with 90% of those cases taking place in developing countries (Singh & Trevick, 2016). Epilepsy can be defined as at least two unprovoked seizures occurring more than 24 hours apart, one unprovoked seizure with at least 60% chance of another seizure occurring within the next 10 years, or a diagnosis of epilepsy syndrome (Fisher et al., 2005). Varying physiological, molecular, genetic, and environmental factors can contribute to epileptic episodes. Although antiepileptic drugs (AEDs) exist, the complexity and lack of understanding behind the molecular mechanisms of the syndrome leaves the few drugs available to be insufficient for many patients (Rho & White, 2018). Therefore, the discovery of genetic pathways involved in epilepsy is imperative for the innovation of antiepileptic drugs. This thesis explores a novel method to add to mutant C.elegans libraries and improve antiepileptic drug discovery in a cost-effective and efficient manner by uncovering candidate molecular pathways through the candidate genes involved with antiepileptic strains.
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Date Issued: 2022
PURL: http://purl.flvc.org/fau/fd/FA00014049
Subject Headings: Caenorhabditis elegans, Epilepsy, Drug development
Format: Document (PDF)

Title: Dose-dependent arrhythmia and cardiac dysfunction in restrictive cardiomyopathy mice due to troponin mutations.
Creator: Li, Yuejin, Jean-Charles, Pierre-Yves, Nan, Changlong, Chen, Guozhen, Graduate College, Huang, Xupei
Date Issued: 2011-04-08
PURL: http://purl.flvc.org/fcla/dt/3164611
Subject Headings: Arrhythmia --drug therapy, Heart failure, Proteomics
Format: Document (PDF)

Title: The discovery of marine natural products with therapeutic potential.
Creator: McConnell, O. J., Longley, Ross E., Koehn, F. E., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/fau/fd/FA00007447
Subject Headings: Marine natural products, Drug Discovery, Pharmacognosy
Format: Document (PDF)

Title: Marine organisms as a source of novel lead structures for drug development.
Creator: Wright, Amy E.
Date Issued: 2000
PURL: http://purl.flvc.org/fau/fd/FA00007060
Subject Headings: Marine organisms, Marine natural products, Drug development
Format: Document (PDF)

Title: The oceans and human health: the discovery and development of marine-derived drugs.
Creator: Pomponi, Shirley A.
Date Issued: 2001
PURL: http://purl.flvc.org/fau/fd/FA00007240
Subject Headings: Marine natural products, Marine pharmacology, Drug development
Format: Document (PDF)

Title: Verongamine, a novel bromotyrosine derived histamine H3-antagonist from the marine sponge Verongula gigantea.
Creator: Mierzwa, Ronald, King, Arthur, Conover, M. A., Tozzi, S., Puar, M. S., Patel, Mahesh, Coval, S. J., Pomponi, Shirley A.
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3318974
Subject Headings: Sponges --Research, Marine natural products, Drug Discovery
Format: Document (PDF)

Title: Cortical KCI reinstates forelimb placing following damage to the internal capsule.
Creator: Wolgin, David L., Kehoe, Priscilla
Date Issued: 1983-08
PURL: http://purl.flvc.org/fau/228749
Subject Headings: Physiology--Research., Drugs Physiological effect
Format: Document (PDF)

Title: Effects of chronic amphetamine on the appetitive and consummatory phases of feeding.
Creator: Wolgin, David L.
Date Issued: 2002-06
PURL: http://purl.flvc.org/fau/228706
Subject Headings: Behavior-drug effects., Neuropharmacology--Research.
Format: Document (PDF)

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