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Halitunal, an unusual diterpene aldehyde from the marine alga Halimeda tuna
Title
Halitunal, an unusual diterpene aldehyde from the marine alga Halimeda tuna.
Creator
Koehn, F. E., Gunasekera, Sarath P., Niel, D. N., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3353864
Subject Headings
Halimeda, Green algae, Microalgae, Diterpenes, Antiviral agents
Format
Document (PDF)
Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge
Title
Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge.
Creator
Kashman, Y., Hirsch, S., Koehn, F. E., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353808
Subject Headings
Antiviral agents, Diterpenes, Sponges, Marine metabolites
Format
Document (PDF)
Isospongiadiol, a cytotoxic and antiviral diterpene from a Caribbean deep water marine sponge, Spongia sp.
Title
Isospongiadiol, a cytotoxic and antiviral diterpene from a Caribbean deep water marine sponge, Spongia sp.
Creator
Kohmoto, S., McConnell, O. J., Wright, Amy E., Cross, S. S.
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3343811
Subject Headings
Sponges--Caribbean Sea, Diterpenes, Antiviral agents
Format
Document (PDF)
Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx
Title
Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx.
Creator
Sennett, Susan H., Pomponi, Shirley A., Wright, Amy E.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333004
Subject Headings
Sponges, Diterpenes, Marine metabolites, Chemical structure
Format
Document (PDF)
A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli
Title
A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli.
Creator
Coval, S. J., Patton, R. W., Petrin, J. M., James, L., Rothofsky, M. L., Lin, S. L., Patel, Mahesh, Reed, John K., McPhail, A. T., Bishop, W. R.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3331913
Subject Headings
Corals, Alcyoniidae, Ras proteins, Diterpenes, Antineoplastic agents
Format
Document (PDF)
Natural Product Studies of Marine Organisms from the Western Atlantic
Title
Natural Product Studies of Marine Organisms from the Western Atlantic.
Creator
Hall, Andrew, West, Lyndon, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The projects described in this dissertation are focused on compounds derived from marine organisms collected from the western Atlantic marine environment. Chapter 1 provides an introduction to the study of natural products chemistry, marine natural products, and overview of the research undertaken from natural product chemists. Chapter 2 describes the isolation and structure elucidation of a series of rare diterpenoids from the gorgonian Briareum asbestinum, together with their conformational...
Show moreThe projects described in this dissertation are focused on compounds derived from marine organisms collected from the western Atlantic marine environment. Chapter 1 provides an introduction to the study of natural products chemistry, marine natural products, and overview of the research undertaken from natural product chemists. Chapter 2 describes the isolation and structure elucidation of a series of rare diterpenoids from the gorgonian Briareum asbestinum, together with their conformational analysis and biosynthetic interconversions. These rare diterpenes from Briareum asbestinum are linked by an unusual transannular oxa-6π electrocyclization which is described in detail and this work demonstates the biomimetic hemisynthesis of briareolate esters L (19) to B (22) achieved via an intermediary, briareolate ester G (2), through a controlled set of photoinduced isomerizations and a unique photochromic transannular oxa-6π electrocyclization. This work focuses largely on the mechanistic understanding of the photochemical production of these briarane diterpenoids and illustrates a unique UVA/UVC, photochromic switch which induces a transannular oxa- 6π electrocyclization. Chapter 3 describes the assay-guided isolation of marine antioxidants. This chapter focuses on the screening of marine organism extracts using the Ferric Reducing Antioxidant Power (FRAP) assay for antioxidant activity guided isolation of marine natural products. The chapter concludes with the activity guided isolation and structural elucidation of 1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)- glycerol (40) to show direct antioxidant potential through FRAP analysis. Chapter 4 describes the isolation, structural elucidation and pharmacological evaluation of the novel secondary metabolites iso-PsA(45), Iso-PsC (46), iso-PsD (47) as well as known Pseudopterosins A(41), B(42), C(43), D(44), K(48), K2’OAc(49), K2’OAc(50). These secondary metabolites were evaluated for both cytotoxicity. The chapter concludes with the screening of these compounds as αβ-amyloid fibril modulators utilizing atomic force microcopy (AFM).
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004666
Subject Headings
Marine natural products., Diterpenes., Marine metabolites
Format
Document (PDF)
Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum
Title
Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum.
Creator
Coval, S. J., Cross, S. S., Bernardinelli, G., Jefford, C. W., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332954
Subject Headings
Corals--Caribbean Sea, Gorgonacea, Diterpenes, Antiviral agents, Cytotoxin
Format
Document (PDF)
Exploration of Methods to Identify Biosynthetic Genes and the Origin of Biosynthesis in Marine Octocorals
Title
Exploration of Methods to Identify Biosynthetic Genes and the Origin of Biosynthesis in Marine Octocorals.
Creator
Ranzer, Llanie Karen, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The overall goal of this research was to isolate key genes involved in the diterpene biosynthesis from Euniceafusca and Erythropodium caribaeorum using molecular biology techniques. The initial goal was to use fuscol induced cell cultures of Symbiodinium sp. isolated from E. fusca and to develop an approach based on differential display of mRNA-reverse transcription-PeR. Together with inverse PCR, these techniques ultimately provided a full-length farnesyl diphosphate synthase sequence....
Show moreThe overall goal of this research was to isolate key genes involved in the diterpene biosynthesis from Euniceafusca and Erythropodium caribaeorum using molecular biology techniques. The initial goal was to use fuscol induced cell cultures of Symbiodinium sp. isolated from E. fusca and to develop an approach based on differential display of mRNA-reverse transcription-PeR. Together with inverse PCR, these techniques ultimately provided a full-length farnesyl diphosphate synthase sequence. Functional expression of this enzyme was demonstrated with the addition of appropriate substrates and confirmed by chromatography. From this data, degenerate primer based PCR was used to isolate putative geranylgeranyl diphosphate biosynthetic genes from E. caribaeorum. Both chemical and genetic examinations of Pseudopterogorgia elisabethae eggs and their associated Symbiodinium sp. were employed to identify the biosynthetic origin of their diterpenes. Terpene content and biosynthetic capabilities of azooxanthellae eggs demonstrated the presence of pseudopterosins but also indicated that the eggs were not capable of producing these compounds. Likewise, no correlation could be observed for the phylogenetic relationships inferred for the Symbiodinium sp., with that of the terpene chemistry present in P. elisabethae. This finding leads us to speculate about an additional source of terpene production within this coral. Based on these and other recent findings suggesting symbiotic bacteria as the source of secondary metabolites from marine invertebrates, bacterial assemblages from E. caribaeorum were examined. This study revealed considerable phylogenetic bacterial diversity within this coral and the identification of several bacteria known to produce terpenes in other organisms.
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Date Issued
2006
PURL
http://purl.flvc.org/fau/fd/FA00000874
Subject Headings
Coral reef ecology, Diterpenes, Biosynthesis, Terpenes--Synthesis
Format
Document (PDF)
Microbial community analysis of the octocoral Eunice a fusca; combined use of cultivation-dependent and independent techniques
Title
Microbial community analysis of the octocoral Eunice a fusca; combined use of cultivation-dependent and independent techniques.
Creator
Duque-Alarcon, Angela Patricia, Kerr, Russell G., Florida Atlantic University
Abstract/Description
The octocoral Eunicea fusca is the source of important anti-inflammatory compounds such as the diterpenes fuscol and the fuscosides. Evidence suggests that these compounds are being produce by bacterial sources that live in symbiosis with the coral. As part of an investigation to better understand the role of bacteria associated with E. fusca , the characterization of the bacterial community using two different techniques (culture dependent technique and culture independent technique) and sea...
Show moreThe octocoral Eunicea fusca is the source of important anti-inflammatory compounds such as the diterpenes fuscol and the fuscosides. Evidence suggests that these compounds are being produce by bacterial sources that live in symbiosis with the coral. As part of an investigation to better understand the role of bacteria associated with E. fusca , the characterization of the bacterial community using two different techniques (culture dependent technique and culture independent technique) and sea water samples was done. Sea water samples were used as a control to determine how closely associated bacteria are to this octocoral. The polymerase chain reaction (PCR) with universal bacterial primers FC27 and RC 1492 specific to prokaryotic 16S rDNA gene sequences was used to characterize the total bacterial population when using both the culturable and the non-culturable approaches. The results indicate a diverse group of bacteria associated to E. fusca composed of 10 different groups. The pro teo bacteria group was the most predominant group when both techniques were used. The a-proteobacteria represented the highest percentage of bacteria associated to E. fusca.
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Date Issued
2007
PURL
http://purl.flvc.org/fau/fd/FA00000748
Subject Headings
Diterpenes--Synthesis, Anti-inflammatory agents, Marine pharmacology, Biodiversity
Format
Document (PDF)
Isolation, Characterization and Synthesis of New Diterpenes from Pseudopterogorgia elisabethae
Title
Isolation, Characterization and Synthesis of New Diterpenes from Pseudopterogorgia elisabethae.
Creator
Wan, Zhongliang, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Pseudopterogorgia elisabethae is a known source of structurally interesting bioactive metabolites. A detailed search for new, related compounds was undertaken in this study which resulted in the isolation and characterization of more than ten new diterpenes with serrulatane and ileabethane skeletons. Some of the new compounds isolated are closely related terpenes with significant biological activity and others are likely to be key biosynthetic intermediates. As a component of the development...
Show morePseudopterogorgia elisabethae is a known source of structurally interesting bioactive metabolites. A detailed search for new, related compounds was undertaken in this study which resulted in the isolation and characterization of more than ten new diterpenes with serrulatane and ileabethane skeletons. Some of the new compounds isolated are closely related terpenes with significant biological activity and others are likely to be key biosynthetic intermediates. As a component of the development of a production method of anti-inflammatory compounds such as seco-pseudopterosin and elisabethadione, a synthesis of a seco-pseudoperosin aglycone from elisabethatriene was developed.
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Date Issued
2006
PURL
http://purl.flvc.org/fau/fd/FA00000883
Subject Headings
Biosynthesis, Diterpenes--Synthesis, Marine invertebrates, Anti-inflammatory agents
Format
Document (PDF)