Current Search: Chitosan (x)
-
-
Title
-
The synthesis of chitosan-cis-DDP derivative.
-
Creator
-
Francis, Ann-Marie, Florida Atlantic University, Louda, Deborah W., Carraher, Charles E.
-
Abstract/Description
-
The formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity...
Show moreThe formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity of cis-DDP but produce fewer toxic side effects. Structural characterization involved infrared spectroscopy, mass spectroscopy, EDAX analytical methods. Products were also analyzed using light scattering photometry, elemental analysis and solubility studies. Additionally, the biological activity of water-soluble products was tested against selected cell lines.
Show less
-
Date Issued
-
1999
-
PURL
-
http://purl.flvc.org/fcla/dt/15699
-
Subject Headings
-
Chitosan, Polymeric drugs
-
Format
-
Document (PDF)
-
-
Title
-
Development of a Thermosensitive Trimethyl Chitosan Hydrogel for in situ Tissue Engineering.
-
Creator
-
Qian, Enze, Kang, Yunqing, Florida Atlantic University, College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering
-
Abstract/Description
-
Chitosan was widely studied for applications in tissue regeneration, because of its biodegradability and biocompatibility. However, its insolubility in a neutral solution and long gelation time limit its wide application in tissue engineering. In this thesis, a new chitosan-based biomaterial was synthesized, and its chemical structure and solubility were characterized. Afterwards, the gelation properties (crosslinker, crosslink time, swelling ratio, drug release and biocompatibility) of TMC...
Show moreChitosan was widely studied for applications in tissue regeneration, because of its biodegradability and biocompatibility. However, its insolubility in a neutral solution and long gelation time limit its wide application in tissue engineering. In this thesis, a new chitosan-based biomaterial was synthesized, and its chemical structure and solubility were characterized. Afterwards, the gelation properties (crosslinker, crosslink time, swelling ratio, drug release and biocompatibility) of TMC material was investigated. Results show that TMC has higher water solubility than chitosan. The TMC liquid solution can transform to a hydrogel quickly at body temperature. The formed hydrogel controlled the release of the model protein. Cytotoxicity result shows the cationic TMC hydrogel brings a toxic effect on stromal cells but it may have the potential to inhibit bacteria or cancer cells, although more studied are required to confirm its potential functions. In summary, this new TMC hydrogel has a promising potential in biomedical fields.
Show less
-
Date Issued
-
2018
-
PURL
-
http://purl.flvc.org/fau/fd/FA00013095
-
Subject Headings
-
Tissue engineering., Chitosan--Biotechnology., Hydrogels.
-
Format
-
Document (PDF)
