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Bryozoan-algal associations in coastal and continental shelf waters of eastern Florida
Title
Bryozoan-algal associations in coastal and continental shelf waters of eastern Florida.
Creator
Winston, Judith E., Eiseman, N. J., Harbor Branch Oceanographic Institute
Date Issued
1980
PURL
http://purl.flvc.org/FCLA/DT/3183151
Subject Headings
Algae, Bryozoa, Algae Ecology, Bryozoa--Morphology
Format
Document (PDF)
Biochemical and biosynthetic optimization of bryostatin 1 in Bugula neritina
Title
Biochemical and biosynthetic optimization of bryostatin 1 in Bugula neritina.
Creator
Vicchiarelli, Richard, Florida Atlantic University, Kerr, Russell G.
Abstract/Description
Bryostatin 1 is a macrocyclic lactone isolated from the marine bryozoan Bugula neritina. It is currently in clinical trials at the National Cancer Institute as a promising new antileukemic agent. Bryostatin 1 is found in Bugula neritina in poor yields (10^-4% dry weight). The focus of this research was to develop the biochemical and biosynthetic techniques that could be utilized to optimize the production of bryostatin 1 in Bugula neritina through aquaculture. To that end, the basic...
Show moreBryostatin 1 is a macrocyclic lactone isolated from the marine bryozoan Bugula neritina. It is currently in clinical trials at the National Cancer Institute as a promising new antileukemic agent. Bryostatin 1 is found in Bugula neritina in poor yields (10^-4% dry weight). The focus of this research was to develop the biochemical and biosynthetic techniques that could be utilized to optimize the production of bryostatin 1 in Bugula neritina through aquaculture. To that end, the basic biosynthetic pathway to bryostatin 1 in the marine bryozoan was evaluated by using radiolabeled precursors. Techniques for the incorporation of these precursors were also developed. Other experiments involved an analysis of the composition of a specific population of Bugula neritina in terms of its bryostatin and lipid content. A determination of which lipids are produced de novo and which are exogenous was also undertaken.
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Date Issued
1993
PURL
http://purl.flvc.org/fcla/dt/14931
Subject Headings
Bryozoa, Aquaculture--Research
Format
Document (PDF)
Studies on fouling invertebrates in the Indian River: 1. Seasonality of settlement
Title
Studies on fouling invertebrates in the Indian River: 1. Seasonality of settlement.
Creator
Mook, David H., Harbor Branch Oceanographic Institute
Date Issued
1976
PURL
http://purl.flvc.org/FCLA/DT/3174432
Subject Headings
Fouling, Invertebrates, Estuaries, Hydroida, Bryozoa
Format
Document (PDF)
Differential predation by barnacles upon larvae of two bryozoans: spatial effects at small scales
Title
Differential predation by barnacles upon larvae of two bryozoans: spatial effects at small scales.
Creator
Young, Craig M., Cameron, J. Lane, Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3353836
Subject Headings
Predation (Biology), Barnacles, Bryozoa, Larvae
Format
Document (PDF)
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina
Title
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina.
Creator
Lawry, Joseph, Kerr, Russell G., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia,...
Show moreThe bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia, melanoma and nephrotoma. A series of experiments was undertaken to elucidate the biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme preparation and radiolabelled precursors. A regional characterization of Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also described.
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Date Issued
1997
PURL
http://purl.flvc.org/fau/fd/FA00000787
Subject Headings
Macrolide antibiotics, Bryozoa, Marine pharmacology
Format
Document (PDF)
Distribution and ecology of estuarine ectoprocts: A critical review
Title
Distribution and ecology of estuarine ectoprocts: A critical review.
Creator
Winston, Judith E., Harbor Branch Oceanographic Institute
Date Issued
1977
PURL
http://purl.flvc.org/FCLA/DT/3333067
Subject Headings
Ectoprocts, Bryozoa, Brackish water ecology, Estuarine ecology
Format
Document (PDF)
Isolation of the fatty acid synthetase from the marine invertebrate Bugula neritina
Title
Isolation of the fatty acid synthetase from the marine invertebrate Bugula neritina.
Creator
Koh, Francis H., Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The fatty acid synthetase (FAS) from the marine invertebrate Bugula neritina was isolated using cold ethanol precipitation followed by the sequence of G-100 and G-200 size exclusion columns. Native gel analysis indicates the isolation of the FAS and the elution volume from the G-100 column suggests the FAS to be ~282kd. One band with a molecular weight of 66 kDa appeared on the SDS gel of the G-200 sample (F17-30) that eluted at 52.5 mL. The G-200 sample that eluted at 19.2 mL (F1-6)...
Show moreThe fatty acid synthetase (FAS) from the marine invertebrate Bugula neritina was isolated using cold ethanol precipitation followed by the sequence of G-100 and G-200 size exclusion columns. Native gel analysis indicates the isolation of the FAS and the elution volume from the G-100 column suggests the FAS to be ~282kd. One band with a molecular weight of 66 kDa appeared on the SDS gel of the G-200 sample (F17-30) that eluted at 52.5 mL. The G-200 sample that eluted at 19.2 mL (F1-6) displayed two predominant bands on the SDS gel corresponding to molecular weights 66 kDa and 97 kDa. Both F1-6 and F17-30 showed FAS activity displaying de novo production of myristic and palmitic acids. From the sequence of purification starting from the cell-free extract (CFE) to the F17-30 sample, a 240 fold increase in specific activity was observed. The Type II FAS experiments showed no substantial evidence of activity, namely of the beta-Hydroxybutyryl acyl-dehydrase and the enoyl reductase enzymes.
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Date Issued
1998
PURL
http://purl.flvc.org/fcla/dt/15546
Subject Headings
Fatty acids--Synthesis, Marine pharmacology, Bryozoa
Format
Document (PDF)
Polypide morphology and feeding behavior in marine ectoprocts
Title
Polypide morphology and feeding behavior in marine ectoprocts.
Creator
Winston, Judith E., Harbor Branch Oceanographic Institute
Date Issued
1978
PURL
http://purl.flvc.org/FCLA/DT/3174433
Subject Headings
Bryozoa, Animal feeding, Morphology, Senses and sensation, Water currents
Format
Document (PDF)
Rapid and inexpensive quantification of the combined polar components of surface wettability: application to biofouling
Title
Rapid and inexpensive quantification of the combined polar components of surface wettability: application to biofouling.
Creator
Gerhart, D. J., Rittschof, D., Hooper, I. R., Eisenman, K., Meyer, A. E., Baier, R. E., Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3352923
Subject Headings
Fouling, Wettability, Bryozoa, Barnacles, Ascidians, Balanus amphitrite, Bugula
Format
Document (PDF)