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Elucidating the role of Semaphorin 7A in breast cancer
Title
Elucidating the role of Semaphorin 7A in breast cancer.
Creator
Garcia-Areas, Ramon A., lragavarapu-Charyulu, Vijaya, Florida Atlantic University, Charles E Schmidt College of Science, Department of Biomedical Science
Abstract/Description
Solid tumors can hijack many of the same programs used in neurogenesis to enhance tumor growth and metastasis, thereby generating a plethora of neurogenesis-related molecules including semaphorins Among them, we have identified Semaphorin7A (SEMA7A) in breast cancer We first used to the DA-3 mammary tumor model to determine the effect of tumor-derived SEMA7A on immune cells We found that tumor-derived SEMA7A can modulate the production of proangiogenic chemokines CXCL2/MIP-2 and CXCL 1, and...
Show moreSolid tumors can hijack many of the same programs used in neurogenesis to enhance tumor growth and metastasis, thereby generating a plethora of neurogenesis-related molecules including semaphorins Among them, we have identified Semaphorin7A (SEMA7A) in breast cancer We first used to the DA-3 mammary tumor model to determine the effect of tumor-derived SEMA7A on immune cells We found that tumor-derived SEMA7A can modulate the production of proangiogenic chemokines CXCL2/MIP-2 and CXCL 1, and prometastatic MMP-9 in macrophages We next aimed to determine the expression and function of SEMA7A in mammary tumor cells We found that SEMA7A is highly expressed in both metastatic human and murine breast cancer cells We show that both TGF-β and hypoxia elicits the production of SEMA 7 A in mammary cells SEMA7 A shRNA silencing in 4T1 cells resulted in decreased mesenchymal markers MMP-3, MMP-13, Vimentin and TGF-β) SEMA7A silenced cells show increased stiffness with reduced migratory and proliferative potential In vivo, SEMA7A silenced 4T1 tumor bearing mice showed decreased tumor growth and metastasis Genetic ablation of host-derived SEMA7A synergized to further decrease the growth and metastasis of 4T1 cells Our findings suggest novel functional roles for SEMA7A in breast cancer and that SEMA7A could be a novel therapeutic target to limit tumor growth and metastasis
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004802
Subject Headings
Breast--Cancer--Diagnosis, Semaphorins, Protein precursors, Cellular signal transduction, Cell receptors
Format
Document (PDF)
Partnering: An exploration of the process occurring between couples engaged in a Partner Breast Exam Program
Title
Partnering: An exploration of the process occurring between couples engaged in a Partner Breast Exam Program.
Creator
Scheinberg-King, Caryn R., Florida Atlantic University, Hektor, Lynne M.
Abstract/Description
The purpose of this study was to gain an understanding of what happens when partners participate in the Partner Breast Exam Program. A qualitative research design, using a grounded theory approach was used to understand the perspective of the couples participating in "Men Can Too" a Partner Breast Exam program. This approach was chosen because the experience of participation in Partner Breast Exam is "unchartered territory." Preliminary findings suggest that the process of partnering results...
Show moreThe purpose of this study was to gain an understanding of what happens when partners participate in the Partner Breast Exam Program. A qualitative research design, using a grounded theory approach was used to understand the perspective of the couples participating in "Men Can Too" a Partner Breast Exam program. This approach was chosen because the experience of participation in Partner Breast Exam is "unchartered territory." Preliminary findings suggest that the process of partnering results in a synergy between the couples. The three processes that comprise the Dynamics of a Synergistic Couple include: Sharing, Dyad: Male/Female Interaction, and Motivation. Partnering, by removing barriers such as fear, can promote a shared journey toward health for a couple, where they become synergistic partners in health, when they share the burden.
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Date Issued
1996
PURL
http://purl.flvc.org/fcla/dt/15363
Subject Headings
Breast--Cancer--Diagnosis, Breast--Examination, Helping behavior, Men--Attitudes, Women--Health and hygiene, Breast--Cancer--Nursing
Format
Document (PDF)