Current Search: Brain-Derived Neurotrophic Factor (x)
View All Items
- Title
- The role of BDNF in the survival and morphological development of adult-born olfactory neurons.
- Creator
- McDole, Brittnee, Guthrie, Kathleen, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
- Abstract/Description
-
Olfactory Granule cells (GCs) are a population of inhibitory interneurons responsible for maintaining normal olfactory bulb (OB) function and circuitry. Through dendrodendritic synapses with the OBs projection neurons, the GCs regulate information sent to the olfactory cortices. Throughout adulthood, GCs continue to integrate into the OB and contribute to olfactory circuitry. However, only ~50% will integrate and survive longterm. Factors aiding in the survival and morphological development...
Show moreOlfactory Granule cells (GCs) are a population of inhibitory interneurons responsible for maintaining normal olfactory bulb (OB) function and circuitry. Through dendrodendritic synapses with the OBs projection neurons, the GCs regulate information sent to the olfactory cortices. Throughout adulthood, GCs continue to integrate into the OB and contribute to olfactory circuitry. However, only ~50% will integrate and survive longterm. Factors aiding in the survival and morphological development of these neurons are still being explored. The neurotrophin brain-derived neurotrophic factor (BDNF) aids in the survival and dendritic spine maturation/maintenance in several populations of CNS neurons. Investigators show that increasing BDNF in the adult-rodent SVZ stimulates proliferation and increases numbers of new OB GCs. However, attempts to replicate these experiments failed to find that BDNF affects proliferation or survival of adult-born granule cells (abGCs). BDNFs regulation of dendritic spines in the CNS is well characterized. In the OB, absence of BDNF’s receptor on abGCs hinders normal spine development and demonstrates a role for BDNF /TrkB signaling in abGCs development. In this study, we use transgenic mice over-expressing endogenous BDNF in the OB (TgBDNF) to determine how sustained increased in BDNF affect the morphology of olfactory GCs and the survival and development of abGCs. Using protein assays, we discovered that TgBDNF mice have higher BDNF protein levels in their OB. We employed a Golgi-cox staining technique to show that increased BDNF expression leads to an increase in dendritic spines, mainly the mature, headed-type spine on OB GCs. With cell birth-dating using 5-bromo-2’- deoxyuridine (BrdU), immunofluorescent cell markers, TUNEL staining and confocal microscopy, we demonstrate that over-expression of BDNF in the OB does not increase survival of abGCs or reduce cell death in the GC population. Using virally labeled abGCs, we concluded that abGCs in TgBDNF mice had similar integration patterns compared to wild-type (WT) mice, but maintained increases in apical headed-type spine density from 12 to 60 days PI. The evidence combined demonstrates that although increased BDNF does not promote cell survival, BDNF modifies GC morphology and abGC development through its regulation of dendritic spine development, maturation and maintenance in vivo.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FA00013159
- Subject Headings
- Brain-Derived Neurotrophic Factor, Olfactory Bulb, Olfactory Pathways, Neurons
- Format
- Document (PDF)
- Title
- Adult neural stem cell proliferation is not altered in trans-genic mice overexpressing BDNF or mutant HTT in forebrain.
- Creator
- Bahga, Dalbir, Guthrie, Kathleen M.
- Date Issued
- 2012-04-06
- PURL
- http://purl.flvc.org/fcla/dt/3348622
- Subject Headings
- Neural stem cells, Subventricular zone, Brain-derived neuro-trophic factor, Stem cell proliferation
- Format
- Document (PDF)
- Title
- THE EFFECTS OF MINDFULNESS TRAINING ON BDNF LEVELS, DEPRESSION, ANXIETY, AND STRESS LEVELS OF COLLEGE STUDENTS.
- Creator
- Bosso, Kathryn B., Brigman, Greg, Florida Atlantic University, Department of Counselor Education, College of Education
- Abstract/Description
-
The purpose of this randomized control study was to examine the effects of the use of a mindfulness smartphone app on student self-reported levels of depression, anxiety, and stress, and serum levels of brain-derived neurotrophic factor (BDNF). The sample included college students enrolled in courses at a university in South Florida. Forty-four students were randomly allocated to either the mindfulness app group (n = 22) or the control group (n = 22). Participants in the mindfulness app group...
Show moreThe purpose of this randomized control study was to examine the effects of the use of a mindfulness smartphone app on student self-reported levels of depression, anxiety, and stress, and serum levels of brain-derived neurotrophic factor (BDNF). The sample included college students enrolled in courses at a university in South Florida. Forty-four students were randomly allocated to either the mindfulness app group (n = 22) or the control group (n = 22). Participants in the mindfulness app group were instructed to complete a guided meditation on the app for 10 minutes per day for 5 weeks. Participants in the control group were offered the intervention after the 5-week protocol ended. A pretest-posttest design was used to investigate the effects of the mindfulness app intervention on self-reported levels of depression, anxiety, and stress, in addition to serum level BDNF.
Show less - Date Issued
- 2020
- PURL
- http://purl.flvc.org/fau/fd/FA00013452
- Subject Headings
- College students, Mindfulness (Psychology), Brain-Derived Neurotrophic Factor, Depression, Anxiety, Stress
- Format
- Document (PDF)
- Title
- Effects of Resistance and Aerobic Training on IGF-1 and BDNF Expression in a Murine Model of Alzheimer’s Disease.
- Creator
- Pena, Gabriel S., Whitehurst, Michael, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
-
The primary purpose of this study was to investigate the effects of aerobic and resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention groups underwent 9 weeks of exercise training. Motor behavior and grip strength were measured pre- and post- intervention. Our results showed a significant increase in...
Show moreThe primary purpose of this study was to investigate the effects of aerobic and resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention groups underwent 9 weeks of exercise training. Motor behavior and grip strength were measured pre- and post- intervention. Our results showed a significant increase in hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice were found to have higher concentrations of IGF-I, and improved motor behavior when compared to RT and CNT. No significant differences were observed in IGF-I concentration between RT and other groups. RT improved grip strength after nine weeks of training. These findings support the use of AT and RT as a tool to improve comorbidities found in Alzheimer’s disease.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FA00013094
- Subject Headings
- Alzheimer's disease., Insulin-Like Growth Factor I., Brain-Derived Neurotrophic Factor, Aerobic exercises., Resistance Training.
- Format
- Document (PDF)
- Title
- ACUTE RESPONSE OF NEUROPROTECTIVE ASSOCIATED BIOMARKERS TO VARIOUS COMPOUND RESISTANCE EXERCISES IN WELL-TRAINED MEN.
- Creator
- Johnson, Trevor K., Zourdos, Michael C., Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
-
This study examined if multi-joint resistance exercises could elicit expression of biomarkers associated with neuroprotection. Thirteen well-trained males performed 4 sets to failure at 80% of a one-repetition maximum (1RM) on the back squat, bench press, and deadlift. The biomarkers measured immediately pre- and post-exercise were brain derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), cathepsin B (CatB), and interleukin 6 (IL-6). There was a main time effect (p0.05)....
Show moreThis study examined if multi-joint resistance exercises could elicit expression of biomarkers associated with neuroprotection. Thirteen well-trained males performed 4 sets to failure at 80% of a one-repetition maximum (1RM) on the back squat, bench press, and deadlift. The biomarkers measured immediately pre- and post-exercise were brain derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), cathepsin B (CatB), and interleukin 6 (IL-6). There was a main time effect (p<0.01) for BDNF with significant increases in the deadlift (p=0.01) and bench press (p=0.01) conditions, but not the squat (p=0.21). There was a main time effect (p<0.01) for IL-6 with a significant increase in the squat (p<0.01). There was no significant increase in CatB or IGF-1 (p>0.05). Additionally, there was no significant relationship between BDNF and IL-6 response.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FA00013322
- Subject Headings
- Biomarkers, Neuroprotection, Resistance Training, Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor I, Cathepsin B, Interleukin-6, Men.
- Format
- Document (PDF)