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ELEVATED LEVELS OF HYPOTHALAMIC CALCIUM ION OR SODIUM ION: BEHAVIORAL AND PHYSIOLOGICAL THERMOREGULATION IN THE RAT
Title
ELEVATED LEVELS OF HYPOTHALAMIC CALCIUM ION OR SODIUM ION: BEHAVIORAL AND PHYSIOLOGICAL THERMOREGULATION IN THE RAT.
Creator
HACKETT, EARLE RAYMOND, Florida Atlantic University
Abstract/Description
To investigate the effects of elevated levels of hypothalamic Ca++ or Na+ on behavioral and physiological thermoregulation in the rat, bilateral cannula were implanted in various sections of the hypothalamus. In a cold environment, the introduction of artificial cerebrospinal fluid with a Ca++ excess into the posterior hypothalamus was followed by a significant increase in bar holding for 250 watt red-bulb infrared heat. In a neutral environment, introduction of the Ca++- excess solution into...
Show moreTo investigate the effects of elevated levels of hypothalamic Ca++ or Na+ on behavioral and physiological thermoregulation in the rat, bilateral cannula were implanted in various sections of the hypothalamus. In a cold environment, the introduction of artificial cerebrospinal fluid with a Ca++ excess into the posterior hypothalamus was followed by a significant increase in bar holding for 250 watt red-bulb infrared heat. In a neutral environment, introduction of the Ca++- excess solution into the posterior hypothalamus caused a significant increase in body temperature. The introduction of artificial cerebrospinal fluid with a Na+ excess under the same conditions caused respectively a significant decrease in responding for heat and a significant decrease in body temperature. Placements in the preoptic-anterior hypothalamus and lateral hypothalamus produced no significant behavioral or physiological results under either chemical conditions.
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Date Issued
1973
PURL
http://purl.flvc.org/fcla/dt/13602
Subject Headings
Hypothalamus, Body temperature--Regulation, Body temperature--Effect of drugs on
Format
Document (PDF)
effect of ambient temperature on serotonin syndrome
Title
The effect of ambient temperature on serotonin syndrome.
Creator
Krishnamoorthy, Swapna., Charles E. Schmidt College of Medicine
Abstract/Description
Serotonin syndrome (SS) is a drug-induced toxicity caused by an excess of serotonin (5-HT) in the central nervous system (CNS). The symptoms of the disorder range from mild to severe, with the severe state evoking life-threatening hyperthermia. Autonomic dysfunction is controlled in part by serotonin receptors, with the 5-HT2A receptor responsible for increasing core body temperature (Tcor). Our results show that the 5-HT2A receptors on the preoptic/anterior hypothalamus (PO/AH) and...
Show moreSerotonin syndrome (SS) is a drug-induced toxicity caused by an excess of serotonin (5-HT) in the central nervous system (CNS). The symptoms of the disorder range from mild to severe, with the severe state evoking life-threatening hyperthermia. Autonomic dysfunction is controlled in part by serotonin receptors, with the 5-HT2A receptor responsible for increasing core body temperature (Tcor). Our results show that the 5-HT2A receptors on the preoptic/anterior hypothalamus (PO/AH) and prefrontal cortex (PFC), in particular, are sensitive to changes in ambient temperature (Tamb). The toxic increase of 5-HT is postulated to occur due to the temperature-dependent activation of these receptors that promotes a positive feedback mechanism. Our results suggest that changes in Tamb can either exacerbate or alleviate the symptom and that this is mediated by the 5-HT2A receptors. Understanding the mechanism involved in elevating Tcor is imperative in treating and preventing the disorder.
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Date Issued
2008
PURL
http://purl.flvc.org/FAU/186297
Subject Headings
Serotoninergic mechanisms, Central nervous system, Physiology, Body temperature, Regulation, Neurotransmitter receptors, Serotonin, Physiological effect
Format
Document (PDF)