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Ptilomycalin A: a novel polycyclic guanidine alkaloid of marine origin
Title
Ptilomycalin A: a novel polycyclic guanidine alkaloid of marine origin.
Creator
Kashman, Y., Hirsch, S., McConnell, O. J., Ohtani, I., Kusumi, T., Kakisawa, H., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3332964
Subject Headings
Guanidines, Sponges, Bioactive compounds
Format
Document (PDF)
Isolation and structure elucidation of onnamide a, a new bioactive metabolite of a marine sponge, Theonella sp.
Title
Isolation and structure elucidation of onnamide a, a new bioactive metabolite of a marine sponge, Theonella sp.
Creator
Sakemi, S., Ichiba, T., Kohmoto, S., Saucy, G., Higa, T., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332945
Subject Headings
Sponges, Bioactive compounds, Marine metabolites, Marine Toxins
Format
Document (PDF)
Sponge cell culture for production of bioactive metabolites.
Title
Sponge cell culture for production of bioactive metabolites.
Creator
Pomponi, Shirley A., Willoughby, Robin
Date Issued
1994
PURL
http://purl.flvc.org/fau/fd/FA00007381
Subject Headings
Sponges, Cell culture, Metabolites, Bioactive compounds
Format
Document (PDF)
Bioactivity of marine organisms: relationships with taxonomy, geography and depth
Title
Bioactivity of marine organisms: relationships with taxonomy, geography and depth.
Creator
Reed, John K., Sennett, Susan H., McCarthy, Peter J., Pitts, Tara P., Wright, Amy E., Pomponi, Shirley A.
Date Issued
1998
PURL
http://purl.flvc.org/fau/fd/FA00007421
Subject Headings
Marine organisms, Bioactive compounds, Marine natural products
Format
Document (PDF)
Isolation of marine natural products
Title
Isolation of marine natural products.
Creator
Wright, Amy E.
Date Issued
1998
PURL
http://purl.flvc.org/fau/fd/FA00007419
Subject Headings
Marine natural products, Bioactive compounds--Biotechnology
Format
Document (PDF)
Natural products from marine invertebrates: the Harbor Branch Oceanographic Institution experience
Title
Natural products from marine invertebrates: the Harbor Branch Oceanographic Institution experience.
Creator
Sennett, Susan H., McCarthy, Peter J., Wright, Amy E., Pomponi, Shirley A.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/2796027
Subject Headings
Marine invertebrates, Polyketides, Bioactive compounds, Probiotics
Format
Document (PDF)
Sustainable use of deep-sea organisms collected for biomedical research
Title
Sustainable use of deep-sea organisms collected for biomedical research.
Creator
Reed, John K., Pomponi, Shirley A.
Date Issued
2000
PURL
http://purl.flvc.org/fau/fd/FA00007394
Subject Headings
Biomedical Research, Bioactive compounds, Marine natural products
Format
Document (PDF)
Biophysical characterization of bioactive peptide amphiphiles
Title
Biophysical characterization of bioactive peptide amphiphiles.
Creator
Fishel, Ayala, Florida Atlantic University, Fields, Gregg B.
Abstract/Description
In this present work we have examined the biophysical characterization of two peptides. One alpha-helical (SPARC) and the other triple-helical (collagen). We have compared the effect of lipidation on stabilizing of the alpha-helical and triple-helical peptides. For the first peptide, amino acids from the angiogenesis-inducing region of SPARC were incorporated into alpha-helical peptide sequence. A Tyr was placed between the alpha-helical sequence and the peptide to provide a chromophore; Lys...
Show moreIn this present work we have examined the biophysical characterization of two peptides. One alpha-helical (SPARC) and the other triple-helical (collagen). We have compared the effect of lipidation on stabilizing of the alpha-helical and triple-helical peptides. For the first peptide, amino acids from the angiogenesis-inducing region of SPARC were incorporated into alpha-helical peptide sequence. A Tyr was placed between the alpha-helical sequence and the peptide to provide a chromophore; Lys-Ala-Glu-Ile-Glu-Ala-Leu-Lys-Ala-Glu-Ile-Glu-Ala-Leu-Lys-Ala-Tyr-Lys-His-Gly-Lys-NH 2 was the final sequence. For the second peptide, the sequence chosen to mimic the alpha2beta1 integrin binding site in type I collagen was (Gly-Pro-Hyp)4-Gly-Pro-Ala-Gly-Lys-Asp-Gly-Glu-Ala-Gly-Ala-Gln-(Gly-Pro-Hyp) 4-NH2. Next, each peptide was lipidated with a C-16 acid and was biophysically characterized to determine physiological compatibility. Techniques used included circular dichroism spectroscopy, gel electrophoresis, and Fourier transform infrared spectroscopy. Lastly, one of the peptide amphiphiles was examined as a biomaterial modifier.
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Date Issued
2000
PURL
http://purl.flvc.org/fcla/dt/15780
Subject Headings
Peptides--Synthesis, Lipids, Bioactive compounds
Format
Document (PDF)
Two new bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus
Title
Two new bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus.
Creator
Gunasekera, Sarath P., Gunasekera, M., Gunawardana, G. P., McCarthy, Peter J., Burres, N. S.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3332965
Subject Headings
Sponges, Peroxides, Bioactive compounds, Antifungal agents, Cytotoxin, Marine metabolites
Format
Document (PDF)
2,3-Dihydrolinderazulene, a new bioactiveazulene pigment from the gorgonian Acalycigorgia sp.
Title
2,3-Dihydrolinderazulene, a new bioactiveazulene pigment from the gorgonian Acalycigorgia sp.
Creator
Sakemi, S., Higa, T., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/fau/fd/FA00007179
Subject Headings
Azulene, Gorgonacea, Bioactive compounds, Pigments, Antineoplastic agents, Antifungal agents
Format
Document (PDF)
The chemistry and biological activity of five marine sponges of the genus Aplysina
Title
The chemistry and biological activity of five marine sponges of the genus Aplysina.
Creator
Gunasekera, Sarath P., Cross, S. S., Longley, Ross E., Pomponi, Shirley A.
Date Issued
1991
PURL
http://purl.flvc.org/fau/fd/FA00007303
Subject Headings
Sponges, Antiviral agents, Immunosuppressive agents, Bioactive compounds, Marine natural products
Format
Document (PDF)
Synthesis of N-substituted Pyrrolin-2-ones
Title
Synthesis of N-substituted Pyrrolin-2-ones.
Creator
Mattern, R.-H., Harbor Branch Oceanographic Institute
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3331910
Subject Headings
Stereoisomers--Synthesis, Bioactive compounds--Synthesis, Pyrrolidines
Format
Document (PDF)
Development of sponge cell cultures for biomedical application
Title
Development of sponge cell cultures for biomedical application.
Creator
Pomponi, Shirley A., Willoughby, Robin
Date Issued
2000
PURL
http://purl.flvc.org/FCLA/DT/3172822
Subject Headings
Natural products, Pharmacognosy, Bioactive compounds, Sponges, Sponges --Cytology
Format
Document (PDF)
Theopederins K and L. Highly Potent Cytotoxic Metabolites from a Marine Sponge Discodermia Species
Title
Theopederins K and L. Highly Potent Cytotoxic Metabolites from a Marine Sponge Discodermia Species.
Creator
Paul, Gopal K., Gunasekera, Sarath P., Longley, Ross E., Pomponi, Shirley A.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/3164097
Subject Headings
Sponges, Marine metabolites, Bioactive compounds, Natural products, Cytotoxicity, Immunologic
Format
Document (PDF)
The Lithistida: important sources of compounds useful in biomedical research
Title
The Lithistida: important sources of compounds useful in biomedical research.
Creator
Wright, Amy E.
Date Issued
2010
PURL
http://purl.flvc.org/FCLA/DT/3331940
Subject Headings
Sponges, Biomedical research, Marine natural products, Bioactive compounds
Format
Document (PDF)
HBMMD: an enhanced database of the microorganisms associated with deeper water marine invertebrates
Title
HBMMD: an enhanced database of the microorganisms associated with deeper water marine invertebrates.
Creator
Gunasekera, Aravinda S., Sfanos, Karen S., Harmody, Dedra K., Pomponi, Shirley A., McCarthy, Peter J., Lopez, Jose V.
Date Issued
2004
PURL
http://purl.flvc.org/FCLA/DT/2796029
Subject Headings
Marine microbiology, Microorganisms, Marine invertebrates, Bioactive compounds, Sponges
Format
Document (PDF)
Biomedical research in the sea, a search for drugs and novel compounds
Title
Biomedical research in the sea, a search for drugs and novel compounds.
Creator
Reed, John K., Pomponi, Shirley A.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3351938
Subject Headings
Biomedical Research, Marine natural products, Bioactive compounds, Drugs
Format
Document (PDF)
Studies towards the synthesis of Cephalostatin 1
Title
Studies towards the synthesis of Cephalostatin 1.
Creator
Wu, Mao, Florida Atlantic University, Kerr, Russell G.
Abstract/Description
Cephalostatin 1 has been isolated from the colonial marine worm Cephalodiscus gilchristi (Phylum Hemichordata) in the Indian Ocean. It has shown biomedical potential in preclinical trials as a cell growth inhibitor, active against U. S. murine P388 lymphocyte leukemia ED5010^-7-10^-9 μ/ml and a potent growth inhibitor against solid tumor types. Our research is focusing on developing methodology to produce disteroidal pyrazine and the introduction of delta 14, 15 unsaturation and C-16 hydroxyl...
Show moreCephalostatin 1 has been isolated from the colonial marine worm Cephalodiscus gilchristi (Phylum Hemichordata) in the Indian Ocean. It has shown biomedical potential in preclinical trials as a cell growth inhibitor, active against U. S. murine P388 lymphocyte leukemia ED5010^-7-10^-9 μ/ml and a potent growth inhibitor against solid tumor types. Our research is focusing on developing methodology to produce disteroidal pyrazine and the introduction of delta 14, 15 unsaturation and C-16 hydroxyl groups in Cephalostatin 1A. The synthetic intermediates may be useful for biosynthetic studies and also analogues can be used to study structure-activity relationships.
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Date Issued
1995
PURL
http://purl.flvc.org/fcla/dt/15169
Subject Headings
Bioactive compounds, Pharmaceutical chemistry, Cancer--Research, Pyridazines
Format
Document (PDF)
Development of techniques for in vitro production of bioactive natural products from marine sponges
Title
Development of techniques for in vitro production of bioactive natural products from marine sponges.
Creator
Pomponi, Shirley A., Willoughby, Robin, Kaighn, M. E., Wright, Amy E.
Date Issued
1997
PURL
http://purl.flvc.org/fau/fd/FA00007344
Subject Headings
Sponges, Bioactive compounds, Marine natural products, Cell culture, Growth factors, Phytohemagglutinins, Cryopreservation
Format
Document (PDF)
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands
Title
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands.
Creator
Pomponi, Shirley A., Reed, John K., Wright, Amy E., McCarthy, Peter J.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3351966
Subject Headings
Sponges--Turks and Caicos Islands, Bioactive compounds, Marine natural products, Sponges, Demospongiae
Format
Document (PDF)

Pages