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The regulation of mitophagy in a cellualr model of Huntington's disease
Title
The regulation of mitophagy in a cellualr model of Huntington's disease.
Creator
Lambrinos, Nikolle, Sacino, Matthew, Wei, Jianning
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361110
Subject Headings
Huntington's disease, Autophagy, Mitochondrial disorders
Format
Document (PDF)
Identification of C. elegans ortholog of spinster
Title
Identification of C. elegans ortholog of spinster.
Creator
Kobler, Patrick, Jia, Kailiang
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361106
Subject Headings
Autophagy, Lysosomal storage diseases, Caenorhabditis elegans
Format
Document (PDF)
A neuronal G protein-coupled receptor mediates the effect of diet on lifespan and development in Caenorhabditis elegans through autophagy
Title
A neuronal G protein-coupled receptor mediates the effect of diet on lifespan and development in Caenorhabditis elegans through autophagy.
Creator
Parker, Thomas A., Jia, Kailiang, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
Animals rely on the integration of a variety of external cues to understand and respond appropriately to their environment. The relative amounts of food and constitutively secreted pheromone detected by the nematode C. elegans determines how it will develop and grow. Starvation conditions cause the animal to enter a protective stage, termed dauer. Dauer animals are non-eating, long-lived and stress resistant. Yet, when these animals are introduced to food replete conditions they will recover...
Show moreAnimals rely on the integration of a variety of external cues to understand and respond appropriately to their environment. The relative amounts of food and constitutively secreted pheromone detected by the nematode C. elegans determines how it will develop and grow. Starvation conditions cause the animal to enter a protective stage, termed dauer. Dauer animals are non-eating, long-lived and stress resistant. Yet, when these animals are introduced to food replete conditions they will recover from dauer and proceed into normal development. Furthermore, food restriction has been demonstrated to extend the lifespan of a wide-range of species including C. elegans. However, the exact mechanism by which food signals are detected and transduced by C. elegans to influence development and longevity remains unknown. Here, we identify a G protein-coupled receptor (GPCR) DCAR-1 that acts in two chemosensory neurons to mediate food signaling in an autophagy-related manner. The DCAR-1 ligand Dihydrocaffeic acid (DHCA) competes with dauer-inducing pheromone to promote growth. DHCA is a key intermediate in the shikimate pathway, which is required to synthesize folate and aromatic amino acids. We report that dcar-1 mutations influence dauer formation and extend wildtype lifespan via a mechanism of dietary restriction. Moreover, we show that the lifespan extension of dcar-1 mutants is completely dependent on autophagy gene atg- 18. Furthermore, our data suggests metabolites derived from shikimate are food signals that control aging and dauer development through GPCR signaling in C. elegans. These studies will contribute to the delineation of mechanisms behind the beneficial effects of dietary restriction in eukaryotic organisms.
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Date Issued
2019
PURL
http://purl.flvc.org/fau/fd/FA00013338
Subject Headings
Caenorhabditis elegans, Autophagy, Receptors, G-Protein-Coupled, Longevity, Diet
Format
Document (PDF)