Current Search: Anxiety in adolescence (x)
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Title
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Effects of adolescent stress on depressive- and anxiety-like behaviors and hippocampal mossy fibre-CA3 remodeling in the novelty-seeking phenotype: implications for epigenetic regulation of the BDNF gene.
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Creator
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Oztan, Ozge., Charles E. Schmidt College of Medicine, Department of Biomedical Science
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Abstract/Description
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Experimentally naive rats show variance in their locomotor reactivity to novelty, some displaying higher (HR) while others displaying lower (LR) reactivity, associated with vulnerability to stress. LRHR phenotype is proposed as an antecedent to the development of stress hyper responsiveness. Results presented here show emergence of antidepressive-like behavior following peripubertal-juvenile exposure to chronic variable physical (CVP) and chronic variable social stress (CVS) in HR rats, and...
Show moreExperimentally naive rats show variance in their locomotor reactivity to novelty, some displaying higher (HR) while others displaying lower (LR) reactivity, associated with vulnerability to stress. LRHR phenotype is proposed as an antecedent to the development of stress hyper responsiveness. Results presented here show emergence of antidepressive-like behavior following peripubertal-juvenile exposure to chronic variable physical (CVP) and chronic variable social stress (CVS) in HR rats, and depressive-like behavior following CVP in the LRs. The antidepressive-like behavior in HR rats was accompanied by increased levels of acetylated Histone3 (acH3) and acetylated Histone4 (acH4) at the hippocampal brain-derived neurotrophic factor (BDNF) P2 and P4 promoters respectively. This effect may mediate increased mossy fibre (MF) terminal field size, particularly the suprapyramidal mossy fibre projection volume (SP-MF), in the HR animals following both stress regimens. These findings show that chronic variable stress during adolescence induces individual differences in molecular, neuromorphological and behavioral parameters between LRs and HRs, which provides further evidence that individual differences in stress responsiveness is an important factor in resistance or vulnerability to stress-induced depression and/or anxiety.
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Date Issued
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2013
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PURL
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http://purl.flvc.org/fcla/dt/3360950
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Subject Headings
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Rats as laboratory animals, Anxiety in adolescence, Depression in adolescence, Stress (Psychology), Cellular signal transduction, Hippocampus (Brain), Physiology, Genetic regulation, Gene expression
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Format
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Document (PDF)
