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Synthesis of thiadiazole- and diazepine-based acyclonucleosides with potential anticancer or antiviral activity
Title
Synthesis of thiadiazole- and diazepine-based acyclonucleosides with potential anticancer or antiviral activity.
Creator
Wang, Zhenling, Florida Atlantic University, Baker, Earl W.
Abstract/Description
Cancer is a large group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled or checked, it results in death. Cancer is one of the leading causes of death in Western societies. In the United States, cancer is the second leading killer. However, many cancers can be cured if detected early and treated promptly. This paper analyzes the synthesis of thiadiazole- and diazepine-based acyclonucleosides with potential anticancer or antiviral...
Show moreCancer is a large group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled or checked, it results in death. Cancer is one of the leading causes of death in Western societies. In the United States, cancer is the second leading killer. However, many cancers can be cured if detected early and treated promptly. This paper analyzes the synthesis of thiadiazole- and diazepine-based acyclonucleosides with potential anticancer or antiviral activity.
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Date Issued
1992
PURL
http://purl.flvc.org/fcla/dt/14815
Subject Headings
Cancer, Antiviral agents, Nucleosides
Format
Document (PDF)
Halitunal, an unusual diterpene aldehyde from the marine alga Halimeda tuna
Title
Halitunal, an unusual diterpene aldehyde from the marine alga Halimeda tuna.
Creator
Koehn, F. E., Gunasekera, Sarath P., Niel, D. N., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3353864
Subject Headings
Halimeda, Green algae, Microalgae, Diterpenes, Antiviral agents
Format
Document (PDF)
Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge
Title
Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge.
Creator
Kashman, Y., Hirsch, S., Koehn, F. E., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353808
Subject Headings
Antiviral agents, Diterpenes, Sponges, Marine metabolites
Format
Document (PDF)
Isospongiadiol, a cytotoxic and antiviral diterpene from a Caribbean deep water marine sponge, Spongia sp.
Title
Isospongiadiol, a cytotoxic and antiviral diterpene from a Caribbean deep water marine sponge, Spongia sp.
Creator
Kohmoto, S., McConnell, O. J., Wright, Amy E., Cross, S. S.
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3343811
Subject Headings
Sponges--Caribbean Sea, Diterpenes, Antiviral agents
Format
Document (PDF)
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi
Title
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi.
Creator
Koehn, F. E., Gunasekera, M., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332977
Subject Headings
Sponges, Sterols, Marine natural products, Antiviral agents
Format
Document (PDF)
Venustatriol. A new, anti-viral, triterpene tetracyclic ether from Laurencia venusta
Title
Venustatriol. A new, anti-viral, triterpene tetracyclic ether from Laurencia venusta.
Creator
Sakemi, S., Higa, T., Jefford, C. W., Bernardinelli, G., Harbor Branch Oceanographic Institute
Date Issued
1986
PURL
http://purl.flvc.org/FCLA/DT/3353796
Subject Headings
Triterpenes, Laurencia, Squalene, Marine metabolites, Antiviral agents
Format
Document (PDF)
Tubastrine, a new guanidinostyrene from the coral Tubastrea aurea
Title
Tubastrine, a new guanidinostyrene from the coral Tubastrea aurea.
Creator
Sakai, R., Higa, T., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3343809
Subject Headings
Coral, Antiviral agents, Herpes simplex virus, Rhabdoviruses
Format
Document (PDF)
The chemistry and biological activity of five marine sponges of the genus Aplysina
Title
The chemistry and biological activity of five marine sponges of the genus Aplysina.
Creator
Gunasekera, Sarath P., Cross, S. S., Longley, Ross E., Pomponi, Shirley A.
Date Issued
1991
PURL
http://purl.flvc.org/fau/fd/FA00007303
Subject Headings
Sponges, Antiviral agents, Immunosuppressive agents, Bioactive compounds, Marine natural products
Format
Document (PDF)
Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin; antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies
Title
Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin; antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies.
Creator
Tsujii, S., Rinehart, Kenneth L., Gunasekera, Sarath P., Kashman, Y., Cross, S. S., Lui, M. S., Pomponi, Shirley A., Diaz, Maria Cristina
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332952
Subject Headings
Sponges--Caribbean Sea, Imidazoles, Indoles, Antiviral agents, Antineoplastic agents
Format
Document (PDF)
Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum
Title
Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum.
Creator
Coval, S. J., Cross, S. S., Bernardinelli, G., Jefford, C. W., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332954
Subject Headings
Corals--Caribbean Sea, Gorgonacea, Diterpenes, Antiviral agents, Cytotoxin
Format
Document (PDF)
Weinbersterol disulfates A and B, antiviral steroid sulfates from the sponge Petrosia Weinbergi
Title
Weinbersterol disulfates A and B, antiviral steroid sulfates from the sponge Petrosia Weinbergi.
Creator
Sun, H. H., Cross, S. S., Gunasekera, M., Koehn, F. E., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3353862
Subject Headings
Antiviral agents, Sponges--Research, Leukemia virus, Feline, HIV
Format
Document (PDF)
Synthesis and In Vitro Evaluation of Some Novel Nucleoside analogs and DNA lntercalators as Potential Anticancer or Antiviral Agents
Title
Synthesis and In Vitro Evaluation of Some Novel Nucleoside analogs and DNA lntercalators as Potential Anticancer or Antiviral Agents.
Creator
Zhao, Yuxiang, Florida Atlantic University, Parkanyi, Cyril, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Thiadiazoles can be considered as analogs of pyrimidines because of the well known analogy between a -CH=CH- group in benzenoid hydrocarbons and bivalent sulfur, -S-, in aromatic heterocycles. Therefore, 5-amino-2H-1 ,2,4-thiadiazole-3-one and 5-amino-3H-1 ,3,4-thiadiazole-2-one are the analogs of cytosine. In our first project, the preparation of six thiadiazole nucleoside analogs is reported: 5-diacetylamino-1 ,2,4- thiadiazol-3-one (1), 5-amino-2-(tetrahydrofuran-2-yl)-1 ,2,4-thiadiazol-3...
Show moreThiadiazoles can be considered as analogs of pyrimidines because of the well known analogy between a -CH=CH- group in benzenoid hydrocarbons and bivalent sulfur, -S-, in aromatic heterocycles. Therefore, 5-amino-2H-1 ,2,4-thiadiazole-3-one and 5-amino-3H-1 ,3,4-thiadiazole-2-one are the analogs of cytosine. In our first project, the preparation of six thiadiazole nucleoside analogs is reported: 5-diacetylamino-1 ,2,4- thiadiazol-3-one (1), 5-amino-2-(tetrahydrofuran-2-yl)-1 ,2,4-thiadiazol-3-one (2), 5- amino-3-((2' -hydroxyethoxy)methyl)-1 ,3,4-thiadiazol-2-one (3), 5-amino-3-( 4' -hydroxy- 2' -hydroxyrnethyl-butyl)-1 ,3,4-thiadiazole-2-thione ( 4), (R)-5-am ino-3-(2' ,3' - dihydroxypropyl)-1 ,3,4-thiadiazole-2-thione (5), and (S)-5-amino-3-(2' ,3 ' - dihydroxypropyl )-1 ,3,4-thiadiazole-2-thione (6). (R)-5-amino-3-(2' ,3' -dihydroxypropyl)-1,3,4-thiadiazole-2-thione (5) and (S)-5-amino-3-(2' ,3' -dihydroxypropyl)-1 ,3,4- thiadiazole-2-thione (6) are stereoisomers. Their racemic mixture 7 was also prepared and tested. The synthesis, characterization, and properties of these new synthesized thiadiazole derivatives are discussed. A dimerization of 5-amino-3H-1 ,3 ,4-thiadiazole-2- thione (18) to produce di-(5-amino-1 ,3,4-thiadiazol-2-yl) disulfide (23) by sodium nitrite with either acetic acid or stannic chloride is also reported. Preliminary results indicate that 3 and 23 possess antimicrobial activity. In the second project, the synthesis of three series of bis-aminochloropyrimidine derivatives with different types of linkers as potential DNA intercalators is described. The first series are aminochloropyrimidines bridged by polyrnethylene chain linkers with various lengths. The second series are bridged by polyether linkers to lower the lipophilicity. The third series are bridged by linkers containing benzene rings to limit the flexibility. The spectral data and other physical properties of the new compounds are discussed. The preliminary screening results indicate that many new synthesized bisintercalators are biologically active. The relationship between bioactivity and structure is discussed as well.
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Date Issued
2007
PURL
http://purl.flvc.org/fau/fd/FA00000886
Subject Headings
Biopharmaceutics, Antineoplastic agents--Pharmacodynamics, Nucleosides--Metabolism, Pharmaceutical chemistry, Antiviral agents--Synthesis
Format
Document (PDF)
Proteomic identification of N86-hnRNPU-interacting proteins involved in HIV-1 inhibition
Title
Proteomic identification of N86-hnRNPU-interacting proteins involved in HIV-1 inhibition.
Creator
Hoxha, Sarah., Harriet L. Wilkes Honors College
Abstract/Description
HIV-1 is the human immunodeficiency virus that can lead to acquired immune deficiency syndrome, or AIDS. Multiple cellular proteins have been identified as playing a critical role in all steps of HIV-1 replication. The heterogeneous nuclear ribonuclear protein U, or hnRNPU is a RNA and DNA binding protein known to influence pre-mRNA processsing, transport to the cytoplasm, intracellular localization, translation and turnover of mRNAs. Recently, the expression of N86-hnRNPU, an N-terminal...
Show moreHIV-1 is the human immunodeficiency virus that can lead to acquired immune deficiency syndrome, or AIDS. Multiple cellular proteins have been identified as playing a critical role in all steps of HIV-1 replication. The heterogeneous nuclear ribonuclear protein U, or hnRNPU is a RNA and DNA binding protein known to influence pre-mRNA processsing, transport to the cytoplasm, intracellular localization, translation and turnover of mRNAs. Recently, the expression of N86-hnRNPU, an N-terminal fragment of hnRNPU, was found to inhibit HIV-1 mRNA export (6). This study primarily aims at identifying proteins that associate with the fragment (N86-hnRNPU) also called H1, and secondarily aims to exclude the possibility that N86-hnRNPU transcripts act as microRNAs.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3359314
Subject Headings
Enzyme inhibitors, Proteinase, Inhibitors, HIV infections, Prevention, HIV infections, Pathogenesis, Antiviral agents
Format
Document (PDF)