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biosynthetic production of pseudopterosin C: An anti-inflammatory agent from a marine soft coral
Title
The biosynthetic production of pseudopterosin C: An anti-inflammatory agent from a marine soft coral.
Creator
Mydlarz, Laura D., Florida Atlantic University, Kerr, Russell G., Binninger, David
Abstract/Description
Pseudopterosin C is a novel diterpene glycoside isolated from the Caribbean gorgonian coral, Pseudopterogorgia elisabethae. Pseudopterosin C is non-steroidal and has been shown to exhibit promising anti-inflammatory and analgesic properties. The in vitro production of pseudopterosin C through biosynthetic methods has been examined. A cell-free system as well as an enzyme precipitate capable of transforming terpene precursors to the product has been developed. The parameters toward optimizing...
Show morePseudopterosin C is a novel diterpene glycoside isolated from the Caribbean gorgonian coral, Pseudopterogorgia elisabethae. Pseudopterosin C is non-steroidal and has been shown to exhibit promising anti-inflammatory and analgesic properties. The in vitro production of pseudopterosin C through biosynthetic methods has been examined. A cell-free system as well as an enzyme precipitate capable of transforming terpene precursors to the product has been developed. The parameters toward optimizing the enzymatic production through cofactor requirements, differing terpene precursors and sugars were investigated.
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Date Issued
1998
PURL
http://purl.flvc.org/fcla/dt/15588
Subject Headings
Anti-inflammatory agents, Alcyonacea, Synthetic drugs
Format
Document (PDF)
The NSAID, Sulindac confers protection against oxidative stress induced damage in retinal pigmented epithelial cells
Title
The NSAID, Sulindac confers protection against oxidative stress induced damage in retinal pigmented epithelial cells.
Creator
Sur, Arunodoy, Biswal, Manas, Kreymerman, Alexander, Weissbach, Herbert, Prentice, Howard, Blanks, Janet C., Graduate College
Date Issued
2011-04-08
PURL
http://purl.flvc.org/fcla/dt/3164798
Subject Headings
Nonsteroidal anti-inflammatory agents, Oxidative stress, Epithelial cells
Format
Document (PDF)
Sulindac enhances the killing of cancer cells exposed to oxidative stress
Title
Sulindac enhances the killing of cancer cells exposed to oxidative stress.
Creator
Kreymerman, Alexander, Ayyanathan, Kasirajan, Kesaraju, Shailaja, Dawson-Scully, Ken, Weissbach, Herbert, Graduate College
Date Issued
2011-04-08
PURL
http://purl.flvc.org/fcla/dt/3164545
Subject Headings
Nonsteroidal anti-inflammatory agents, Oxidative stress, Mitochondrial pathology
Format
Document (PDF)
Microbial community analysis of the octocoral Eunice a fusca; combined use of cultivation-dependent and independent techniques
Title
Microbial community analysis of the octocoral Eunice a fusca; combined use of cultivation-dependent and independent techniques.
Creator
Duque-Alarcon, Angela Patricia, Kerr, Russell G., Florida Atlantic University
Abstract/Description
The octocoral Eunicea fusca is the source of important anti-inflammatory compounds such as the diterpenes fuscol and the fuscosides. Evidence suggests that these compounds are being produce by bacterial sources that live in symbiosis with the coral. As part of an investigation to better understand the role of bacteria associated with E. fusca , the characterization of the bacterial community using two different techniques (culture dependent technique and culture independent technique) and sea...
Show moreThe octocoral Eunicea fusca is the source of important anti-inflammatory compounds such as the diterpenes fuscol and the fuscosides. Evidence suggests that these compounds are being produce by bacterial sources that live in symbiosis with the coral. As part of an investigation to better understand the role of bacteria associated with E. fusca , the characterization of the bacterial community using two different techniques (culture dependent technique and culture independent technique) and sea water samples was done. Sea water samples were used as a control to determine how closely associated bacteria are to this octocoral. The polymerase chain reaction (PCR) with universal bacterial primers FC27 and RC 1492 specific to prokaryotic 16S rDNA gene sequences was used to characterize the total bacterial population when using both the culturable and the non-culturable approaches. The results indicate a diverse group of bacteria associated to E. fusca composed of 10 different groups. The pro teo bacteria group was the most predominant group when both techniques were used. The a-proteobacteria represented the highest percentage of bacteria associated to E. fusca.
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Date Issued
2007
PURL
http://purl.flvc.org/fau/fd/FA00000748
Subject Headings
Diterpenes--Synthesis, Anti-inflammatory agents, Marine pharmacology, Biodiversity
Format
Document (PDF)
Isolation, Characterization and Synthesis of New Diterpenes from Pseudopterogorgia elisabethae
Title
Isolation, Characterization and Synthesis of New Diterpenes from Pseudopterogorgia elisabethae.
Creator
Wan, Zhongliang, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Pseudopterogorgia elisabethae is a known source of structurally interesting bioactive metabolites. A detailed search for new, related compounds was undertaken in this study which resulted in the isolation and characterization of more than ten new diterpenes with serrulatane and ileabethane skeletons. Some of the new compounds isolated are closely related terpenes with significant biological activity and others are likely to be key biosynthetic intermediates. As a component of the development...
Show morePseudopterogorgia elisabethae is a known source of structurally interesting bioactive metabolites. A detailed search for new, related compounds was undertaken in this study which resulted in the isolation and characterization of more than ten new diterpenes with serrulatane and ileabethane skeletons. Some of the new compounds isolated are closely related terpenes with significant biological activity and others are likely to be key biosynthetic intermediates. As a component of the development of a production method of anti-inflammatory compounds such as seco-pseudopterosin and elisabethadione, a synthesis of a seco-pseudoperosin aglycone from elisabethatriene was developed.
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Date Issued
2006
PURL
http://purl.flvc.org/fau/fd/FA00000883
Subject Headings
Biosynthesis, Diterpenes--Synthesis, Marine invertebrates, Anti-inflammatory agents
Format
Document (PDF)
Origin and mechanism of terpene biosynthesis in Pseudopterogorgia spp
Title
Origin and mechanism of terpene biosynthesis in Pseudopterogorgia spp.
Creator
Boehnlein, Jennifer M., Florida Atlantic University, Kerr, Russell G.
Abstract/Description
The goal of this work was to investigate the biosynthetic origins of diterpene natural products (pseudopterosins, kallolides, bipinnatins, and cembrenes) from corals of the genus Pseudopterogorgia as well as the biosynthetic pathways by which they are produced. These studies have shown that the pseudopterosins from Pseudopterogorgia elisabethae are biosynthesized within the algal symbiont (or possibly a bacterium or fungus associated with the symbiont), are not inducible by manipulation of...
Show moreThe goal of this work was to investigate the biosynthetic origins of diterpene natural products (pseudopterosins, kallolides, bipinnatins, and cembrenes) from corals of the genus Pseudopterogorgia as well as the biosynthetic pathways by which they are produced. These studies have shown that the pseudopterosins from Pseudopterogorgia elisabethae are biosynthesized within the algal symbiont (or possibly a bacterium or fungus associated with the symbiont), are not inducible by manipulation of light levels, and do not change as a result of transplantation to new locations. Studies on Pseudopterogorgia bipinnata revealed that only one chemotype is capable of biosynthesizing the kallolide family of diterpenes. The biosynthetic pathway which gives rise to the kallolides has been shown to involve members of another family of diterpenes, the bipinnatins, which coexist within the coral holobiont. Two diterpene cyclase products have been discovered within P. bipinnata chemotype A, cembrene and neocembrene, and it has been shown that neocembrene gives rise to the kallolides. Finally, the enzymatic conversion of bipinnatin J to kallolide A has shown for the first time that these compounds are in fact biogenetically related.
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Date Issued
2006
PURL
http://purl.flvc.org/fcla/dt/12205
Subject Headings
Terpenes--Synthesis, Marine pharmacology, Alcyonacea, Biosynthesis, Anti-inflammatory agents
Format
Document (PDF)