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Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia
Title
Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia.
Creator
Wolgin, David L., Kinney, Gene G.
Date Issued
1992
PURL
http://purl.flvc.org/fau/226864
Subject Headings
Psychopharmacology--Research, Amphetamines--Physiological effects.
Format
Document (PDF)
Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: instrumental contingencies regulate the expression of sensitization
Title
Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: instrumental contingencies regulate the expression of sensitization.
Creator
Wolgin, David L., Hughes, Katherine M., Popi, Lavinia
Date Issued
1998-12-01
PURL
http://purl.flvc.org/fau/226857
Subject Headings
Psychopharmacology--Research., Amphetamines--Physiological effects.
Format
Document (PDF)
Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia
Title
Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia.
Creator
Wolgin, David L., Hughes, Katherine M.
Date Issued
1997-08-01
PURL
http://purl.flvc.org/fau/228486
Subject Headings
Psychopharmacology--Research., Amphetamines--Physiological effects.
Format
Document (PDF)
Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia
Title
Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia.
Creator
Hughes, Katherine M., Florida Atlantic University, Wolgin, David L.
Abstract/Description
The purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was...
Show moreThe purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was available. After a 4 wk drug withdrawal period, both groups lost tolerance and displayed more intense stereotypy than they had prior to drug withdrawal. Therefore, sensitization of stereotypy did not retard the development of tolerance. However, the loss of tolerance following drug withdrawal may have been due to the development of more intense stereotypy and/or the "unlearning" of previously acquired strategies for suppressing stereotypy.
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Date Issued
1996
PURL
http://purl.flvc.org/fcla/dt/15287
Subject Headings
Drug tolerance, Drugs--Physiological effect, Amphetamines--Physiological effect
Format
Document (PDF)
Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine induced hypophagia
Title
Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine induced hypophagia.
Creator
Kinney, Gene G., Florida Atlantic University, Wolgin, David L., Charles E. Schmidt College of Science, Department of Psychology
Abstract/Description
It was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is,...
Show moreIt was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is, sensitized animals were not impaired on milk intake, whereas nonsensitized animals became more sensitive to the hypophagic effect of amphetamine. Further, it was found that animals sensitized to the stereotyped behavioral effects of the drug developed tolerance to this effect, and this tolerance was found to occur both in the presence and absence of milk.
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Date Issued
1992
PURL
http://purl.flvc.org/fcla/dt/14792
Subject Headings
Drug tolerance, Drugs--Physiological effect, Amphetamines--Physiological effect
Format
Document (PDF)
Changes in behavioural contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued feeding tests while drugged
Title
Changes in behavioural contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued feeding tests while drugged.
Creator
Wolgin, David L., Hughes, Katherine M.
Date Issued
2002-07
PURL
http://purl.flvc.org/fau/227254
Subject Headings
Psychopharmacology--Research, Animal experimentation., Amphetamines-Physiological effects.
Format
Document (PDF)
Contingent tolerance to the anorexigenic effects of amphetamine
Title
Contingent tolerance to the anorexigenic effects of amphetamine.
Creator
Wolgin, David L., Carlton, Peter L.
Date Issued
1971-08
PURL
http://purl.flvc.org/fau/228490
Subject Headings
Psychopharmacology--Research., Appetite depressants., Amphetamines--Physiological effect.
Format
Document (PDF)
Role of instrumental learning in tolerance to cathinone hypophagia
Title
Role of instrumental learning in tolerance to cathinone hypophagia.
Creator
Wolgin, David L., Munoz, James R.
Date Issued
2006-04
PURL
http://purl.flvc.org/fau/228492
Subject Headings
Psychopharmacology--Research., Animal Experimentation, Amphetamines--Physiological effects.
Format
Document (PDF)
Tolerance to amphetamine hypophagia: a microstructural analysis of licking behavior in the rat
Title
Tolerance to amphetamine hypophagia: a microstructural analysis of licking behavior in the rat.
Creator
Wolgin, David L., Jakubow, James J.
Date Issued
2003-02
PURL
http://purl.flvc.org/fau/228480
Subject Headings
Psychopharmacology--Research, Animal experimentation., Amphetamines--Physiological effects.
Format
Document (PDF)
Tolerance to amphetamine hypophagia: a real-time depiction of learning to suppress stereotyped movements in the rat
Title
Tolerance to amphetamine hypophagia: a real-time depiction of learning to suppress stereotyped movements in the rat.
Creator
Wolgin, David L., Jakubow, James J.
Date Issued
2004-06
PURL
http://purl.flvc.org/fau/228478
Subject Headings
Psychopharmacology--Research, Amphetamines--Physiological effects., Animal experimentation.
Format
Document (PDF)
Role of anorexia and behavioral activation in amphetamine-induced suppression of feeding: implications for understanding tolerance
Title
Role of anorexia and behavioral activation in amphetamine-induced suppression of feeding: implications for understanding tolerance.
Creator
Wolgin, David L., Salisbury, Juanita J.
Date Issued
1985
PURL
http://purl.flvc.org/fau/228483
Subject Headings
Psychopharmacology--Research, Amphetamines--Physiological effects., Animal experimentation.
Format
Document (PDF)
Learned suppression of stereotypy in amphetamine-treated rats: implications for understanding tolerance to amphetamine 'anorexia'
Title
Learned suppression of stereotypy in amphetamine-treated rats: implications for understanding tolerance to amphetamine 'anorexia'.
Creator
Wolgin, David L., Wade, John Vincent
Date Issued
1995-04
PURL
http://purl.flvc.org/fau/227248
Subject Headings
Psychopharmacology--Research., Amphetamines--Physiological effects., Animal experimentation.
Format
Document (PDF)
Long-term retention of tolerance to amphetamine hypophagia following cessation of drug injections and feeding tests
Title
Long-term retention of tolerance to amphetamine hypophagia following cessation of drug injections and feeding tests.
Creator
Wolgin, David L., Hughes, Katherine M.
Date Issued
2001-10
PURL
http://purl.flvc.org/fau/228747
Subject Headings
Psychopharmacology--Research., Amphetamines--Physiological effects., Appetite depressants.
Format
Document (PDF)
Loss of tolerance to amphetamine-induced hypophagia in rats: homeostatic readjustment vs. instrumental learning
Title
Loss of tolerance to amphetamine-induced hypophagia in rats: homeostatic readjustment vs. instrumental learning.
Creator
Wolgin, David L., Hughes, Katherine M., Popi, Lavinia
Date Issued
1999-09
PURL
http://purl.flvc.org/fau/228632
Subject Headings
Psychopharmacology--Research., Appetite depressants., Amphetamines--Physiological effects.
Format
Document (PDF)
Neural Activity Associated with Tolerance to Amphetamine Hypophagia
Title
Neural Activity Associated with Tolerance to Amphetamine Hypophagia.
Creator
Bachand, Kimberlee D., Wolgin, David L., Florida Atlantic University
Abstract/Description
There is a growing body of literature indicating that drug effects are influenced by the context in which they are taken, and that neuroadaptations resulting from chronic drug use are similarly context dependent. Contingent tolerance to amphetamine-induced hypophagia is mediated by the learned suppression of stereotyped behaviors, and is an example of a drug-environment interaction. This form of behavioral tolerance depends upon instrumental learning, by which rats learn a strategy to...
Show moreThere is a growing body of literature indicating that drug effects are influenced by the context in which they are taken, and that neuroadaptations resulting from chronic drug use are similarly context dependent. Contingent tolerance to amphetamine-induced hypophagia is mediated by the learned suppression of stereotyped behaviors, and is an example of a drug-environment interaction. This form of behavioral tolerance depends upon instrumental learning, by which rats learn a strategy to suppress drug-induced stereotypies that interfere with feeding. Considerable progress has been made in understanding contingent tolerance at the behavioral level; little is known about the neural mechanisms underlying contingent tolerance. Therefore, the purpose of this study was to delineate neural circuitry involved in contingent tolerance. The differential activation of neurons expressing the immediate early gene c-fos was analyzed throughout the brains of amphetamine-tolerant and non-tolerant rats, using the Before-After paradigm; the amphetamine tolerant group received injections of amphetamine (2.0 mg/kg) before access to milk, after-amphetamine and after-saline groups (i.e., nontolerant) received injections of amphetamine after access to milk, and the saline group received saline at both time points. The experimental design permitted us to identify structures uniquely involved in tolerance from those associated with drinking milk, having a history of amphetamine, or receiving an injection of amphetamine on the final test. The unique finding reported here is that when amphetamine is given in an environment containing food, patterns of c-fos are very different than when the drug is given in an environment without food. Results showed that amphetamine-tolerant animals had significant increases in c-fos in a set of interconnected structures throughout the brain, as compared with non-tolerant and saline rats. These data supported the hypothesis that structures associated with the dorsal striatum mediate the response selection of feeding and the inhibition of stereotypies, while the ventral striatum, via instrumental learning, reinforces the selection and inhibition of competing motor behaviors. Results also support the idea that the mechanisms of tolerance involve several neural subsystems that function to modulate motor, motivational, and reward-based learning. Specifically, the learned suppression of stereotypies involves the tolerance "Response Selection," "Reinforcement," and "Instrumental Learning" subsystems.
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Date Issued
2006
PURL
http://purl.flvc.org/fau/fd/FA00000847
Subject Headings
Amphetamines--Physiological effect, Drug tolerance, Drugs--Physiological effect, Rats as laboratory animals
Format
Document (PDF)
effects of cocaine pre-exposure and maternal deprivation in the self-administration of cocaine and amphetamine in neonatal rats
Title
The effects of cocaine pre-exposure and maternal deprivation in the self-administration of cocaine and amphetamine in neonatal rats.
Creator
Ungaro, Giovanna Marisol., Florida Atlantic University, Terry, Leslie M., Johanson, Ingrid B.
Abstract/Description
The effects of cocaine exposure and maternal deprivation on subsequent voluntary ingestion of cocaine and amphetamine was investigated in 7-day-old rat pups in order to further our understanding on the development of drug addiction. Maternally deprived and non-deprived pups were pre-exposed to a cocaine solution masked with 5% orange Tang solution. Four hours later, experimental pups were tested for subsequent cocaine self-administration (SA) (Exp. 1) or amphetamine SA, (Exp. 2), following a...
Show moreThe effects of cocaine exposure and maternal deprivation on subsequent voluntary ingestion of cocaine and amphetamine was investigated in 7-day-old rat pups in order to further our understanding on the development of drug addiction. Maternally deprived and non-deprived pups were pre-exposed to a cocaine solution masked with 5% orange Tang solution. Four hours later, experimental pups were tested for subsequent cocaine self-administration (SA) (Exp. 1) or amphetamine SA, (Exp. 2), following a second deprivation period. Control pups were not deprived during this interval. Pups in both experiments were assessed for dose self-administered and for general activity. Results indicate that cocaine pre-exposure increased cocaine and amphetamine SA, and activity significantly increased after pre-exposure and testing sessions. Lastly, sensitization of the motor effects of cocaine was observed in pups pre-exposed to cocaine. This study provides a potential drug SA animal model not yet investigated in developing animals.
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Date Issued
1999
PURL
http://purl.flvc.org/fcla/dt/15745
Subject Headings
Cocaine--Physiological effect, Amphetamines--Physiological effect, Rats as laboratory animals, Maternal deprivation
Format
Document (PDF)
Tolerance to amphetamine in cannula vs. bottle-fed animals
Title
Tolerance to amphetamine in cannula vs. bottle-fed animals.
Creator
Walls, Julie A., Florida Atlantic University, Wolgin, David L.
Abstract/Description
The effects of amphetamine on the milk intake, body weight, and behavioral activity of bottle- and cannula-fed rats was investigated in a before/after paradigm. Dose response determinations were conducted before (DR 1) and after (DR 2) chronic treatment (45 days) with amphetamine (8.0 mg/kg) given either before or after milk tests, to determine whether tolerance developed to the anorexic effect of the drug. Control groups were given saline during the chronic phase. Both cannula- and bottle...
Show moreThe effects of amphetamine on the milk intake, body weight, and behavioral activity of bottle- and cannula-fed rats was investigated in a before/after paradigm. Dose response determinations were conducted before (DR 1) and after (DR 2) chronic treatment (45 days) with amphetamine (8.0 mg/kg) given either before or after milk tests, to determine whether tolerance developed to the anorexic effect of the drug. Control groups were given saline during the chronic phase. Both cannula- and bottle-fed animals lost a significant amount of weight. Cannula-fed animals drank significantly more than bottle-fed animals throughout the chronic phase. Statistical analysis revealed significant increases in intake from DR 1 to DR 2 for the after and saline cannula-fed groups, and the before, after, and saline bottle-fed groups. All groups showed an increase in intake from DR 1 to DR 2, though the increase of the before cannula-fed group failed to reach statistical significance.
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Date Issued
1997
PURL
http://purl.flvc.org/fcla/dt/15488
Subject Headings
Rats as laboratory animals, Drug tolerance, Drugs--Physiological effect, Amphetamines--Physiological effect
Format
Document (PDF)