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- Title
- Partnering: An exploration of the process occurring between couples engaged in a Partner Breast Exam Program.
- Creator
- Scheinberg-King, Caryn R., Florida Atlantic University, Hektor, Lynne M.
- Abstract/Description
-
The purpose of this study was to gain an understanding of what happens when partners participate in the Partner Breast Exam Program. A qualitative research design, using a grounded theory approach was used to understand the perspective of the couples participating in "Men Can Too" a Partner Breast Exam program. This approach was chosen because the experience of participation in Partner Breast Exam is "unchartered territory." Preliminary findings suggest that the process of partnering results...
Show moreThe purpose of this study was to gain an understanding of what happens when partners participate in the Partner Breast Exam Program. A qualitative research design, using a grounded theory approach was used to understand the perspective of the couples participating in "Men Can Too" a Partner Breast Exam program. This approach was chosen because the experience of participation in Partner Breast Exam is "unchartered territory." Preliminary findings suggest that the process of partnering results in a synergy between the couples. The three processes that comprise the Dynamics of a Synergistic Couple include: Sharing, Dyad: Male/Female Interaction, and Motivation. Partnering, by removing barriers such as fear, can promote a shared journey toward health for a couple, where they become synergistic partners in health, when they share the burden.
Show less - Date Issued
- 1996
- PURL
- http://purl.flvc.org/fcla/dt/15363
- Subject Headings
- Breast--Cancer--Diagnosis, Breast--Examination, Helping behavior, Men--Attitudes, Women--Health and hygiene, Breast--Cancer--Nursing
- Format
- Document (PDF)
- Title
- Mechanisms of protection against ischemic damage in the heart.
- Creator
- Moench, Ian, Charles E. Schmidt College of Science, Department of Biological Sciences
- Abstract/Description
-
Heart disease including ischemic heart disease is the highest contributor to death and morbidity in the western world. The studies presented were conducted to determine possible pathways of protection of the heart against ischemia/reperfusion. We employed adenovirus mediated over-expression of Methionine sulfoxide reductase A (MsrA) in primary neonatal rat cardiac myocytes to determine the effect of this enzyme in protecting against hypoxia/reoxygenation. Cells transfected with MsrA encoding...
Show moreHeart disease including ischemic heart disease is the highest contributor to death and morbidity in the western world. The studies presented were conducted to determine possible pathways of protection of the heart against ischemia/reperfusion. We employed adenovirus mediated over-expression of Methionine sulfoxide reductase A (MsrA) in primary neonatal rat cardiac myocytes to determine the effect of this enzyme in protecting against hypoxia/reoxygenation. Cells transfected with MsrA encoding adenovirus and subjected to hypoxia/reoxygenation exhibited a 45% decrease in apoptosis as compared to controls. Likewise total cell death as determined by levels of Lactate Dehydrogenase (LDH) release was dramatically decreased by MsrA overexpression. The initial hypothesis that led to our testing sulindac was based on the fact that the S epimer of sulindac was a substrate for MsrA and that this compound might function as a catalytic anti-oxidant based on a reaction cycle that involved reductio n to sulindac sulfide followed by oxidation back to sulindac. To test this we examined the protective effect of sulindac in hypoxia re-oxygenation in both cardiac myocytes in culture and using a Langendorff model of myocardial ischemia. Using this model of myocardial ischemia we showed that pre-incubation of hearts with sulindac, or the S and R epimers of sulindac resulted in protection against cell death. We present several lines of evidence that the protective effect of sulindac is not dependent on the Msr enzyme system nor does it involve the well established role of sulindac as a Cyclooxygenase (COX) inhibitor. Numerous signaling pathways have been implicated in myocardial protective mechanisms, many of which require fluctuations in ROS levels as initiators or mediators., Sulindac shows very good potential as a preconditioning agent that could induce tissue protection against oxidative damage.Blocking of preconditioning pathways by administration of the PKC blocker chelerythine abrogated the ischemic protection afforded by sulindac. Secondly, an end-effector of preconditioning, inducible nitric oxide synthase (iNOS),was found to be induced by greater than 5 fold after 48 h prior feeding sulindac.
Show less - Date Issued
- 2008
- PURL
- http://purl.flvc.org/FAU/186291
- Subject Headings
- Biochemical markers, Diagnostic use, Cardiovascular system, Diseases, Diagnosis, Heart, Diseases, Molecular aspects, Medical care, Quality control, Coronary heart disease, Prevention, Apoptosis, Myocardial infarction, Prevention
- Format
- Document (PDF)
