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In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster
Title
In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster.
Creator
Bruce, Lindsay, Singkornrat, Diana, Wilson, Kelsey, Hausman, William, Robbins, Kelli, Huang, Lingxi, Foss, Katie, Binninger, David
Date Issued
2018-11-01
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.3390_antiox7110155_1634240527
Format
Citation
Alternative Biological Roles of Methionine Sulfoxide Reductases in Drosophila melanogaster
Title
Alternative Biological Roles of Methionine Sulfoxide Reductases in Drosophila melanogaster.
Creator
Wilson, Kelsey, Binninger, David, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
The oxidation of methionine (Met) into methionine sulfoxide (met-(o)) leads to deleterious modifications to a variety of cellular constituents. These deleterious alterations can be reversed by enzymes known as methionine sulfoxide reductases (Msr). The Msr (MsrA and MsrB) family of enzymes have been studied extensively for their biological roles in reducing oxidized Met residues back into functional Met. A wide range of studies have focused on Msr both in vivo and in vitro using a variety of...
Show moreThe oxidation of methionine (Met) into methionine sulfoxide (met-(o)) leads to deleterious modifications to a variety of cellular constituents. These deleterious alterations can be reversed by enzymes known as methionine sulfoxide reductases (Msr). The Msr (MsrA and MsrB) family of enzymes have been studied extensively for their biological roles in reducing oxidized Met residues back into functional Met. A wide range of studies have focused on Msr both in vivo and in vitro using a variety of model organisms. More specifically, studies have noted numerous processes affected by the overexpression, under expression, and silencing of MsrA and MsrB. Collectively, the results of these studies have shown that Msr is involved in lifespan and the management of oxidative stress. More recent evidence is emerging that supports existing biological functions of Msr and theorizes the involvement of Msr in numerous biological pathways.
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Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FA00005980
Subject Headings
Drosophila melanogaster, Methionine Sulfoxide Reductases, Oxidative stress
Format
Document (PDF)