Current Search: Hausman, William (x)
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Title
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In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster.
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Creator
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Bruce, Lindsay, Singkornrat, Diana, Wilson, Kelsey, Hausman, William, Robbins, Kelli, Huang, Lingxi, Foss, Katie, Binninger, David
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Date Issued
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2018-11-01
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.3390_antiox7110155_1634240527
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Format
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Citation
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Title
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Developmental delays in methionine sulfoxide reductase mutants in Drosophila Melanogaster.
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Creator
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Hausman, William, Binninger, David, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
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Abstract/Description
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Aging is a biological process that has many detrimental effects due to the accumulation of oxidative damage to key biomolecules due to the action of free radicals. Methionine sulfoxide reductase (Msr) functions to repair oxidative damage to methionine residues. Msr comes in two forms, MsrA and MsrB, each form has been shown to reduce a specific enantiomer of bound and free oxidized methionine. Effects of Msr have yet to be studied in the major developmental stages of Drosophila melanogaster...
Show moreAging is a biological process that has many detrimental effects due to the accumulation of oxidative damage to key biomolecules due to the action of free radicals. Methionine sulfoxide reductase (Msr) functions to repair oxidative damage to methionine residues. Msr comes in two forms, MsrA and MsrB, each form has been shown to reduce a specific enantiomer of bound and free oxidized methionine. Effects of Msr have yet to be studied in the major developmental stages of Drosophila melanogaster despite the enzymes elevated expression during these stages. A developmental timeline was determined for MsrA mutant, MsrB mutant, and double null mutants against a wild type control. Results show that the Msr double mutant is delayed approximately 20 hours in the early/mid third instar stage while each of the single mutants showed no significant difference to the wild type. Data suggests that the reasoning of this phenomenon is due to an issue gaining mass.
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Date Issued
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2014
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PURL
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http://purl.flvc.org/fau/fd/FA00004200, http://purl.flvc.org/fau/fd/FA00004200
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Subject Headings
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Aging -- Molecular aspects, Cellular signal transduction, Drosophila melanogaster -- Genetics, Mitochondrial pathology, Mutation (Biology), Oxidative stress
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Format
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Document (PDF)
