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Synthesis and structural characterization of organotin and group IVB metallocene dichlorides with kinetin
Title
Synthesis and structural characterization of organotin and group IVB metallocene dichlorides with kinetin.
Creator
Chamely-Wiik, Donna M., Florida Atlantic University, Carraher, Charles E.
Abstract/Description
Metal containing polymers were synthesized by reaction of organotin and group IVB metallocene dichlorides with kinetin, a plant growth hormone (PGH), via the interfacial polycondensation process. Product yields were in the range of 40--63% and degrees of polymerization were from 20 to 150. The structures of the products were determined using infrared and mass spectroscopy. Further characterization involved determination of solubility, degree of polymerization and electrical conductivity. The...
Show moreMetal containing polymers were synthesized by reaction of organotin and group IVB metallocene dichlorides with kinetin, a plant growth hormone (PGH), via the interfacial polycondensation process. Product yields were in the range of 40--63% and degrees of polymerization were from 20 to 150. The structures of the products were determined using infrared and mass spectroscopy. Further characterization involved determination of solubility, degree of polymerization and electrical conductivity. The biological potential of the products was tested against selected microorganisms and Balb/3T3 cell lines. One of the products showed activity in the 0.2mug/ml range, one hundredth of that of similar compounds. Germination experiments using the PGH incorporated polymers were performed on sawgrass and cattail seeds as well as selected vegetable seeds and compared to a control. Sawgrass germination, typically in the 0--2% range were increased to about 60% through the treatment with kinetin-containing polymers.
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Date Issued
2000
PURL
http://purl.flvc.org/fcla/dt/12675
Subject Headings
Polymeric composites, Organotin compounds, Plant hormones
Format
Document (PDF)
Combining Chemistry and College Writing: A New Model for an Honors Undergraduate Chemistry Course
Title
Combining Chemistry and College Writing: A New Model for an Honors Undergraduate Chemistry Course.
Creator
Chamely-Wiik, Donna M., Haky, Jerome E., Galin, Jeffrey R., Kasdorf, Krista
Date Issued
2009
PURL
http://purl.flvc.org/fau/fd/FAUIR000231
Format
Citation
From Bhopal to Cold Fusion: A Case-Study Approach to Writing Assignments in Honors General Chemistry
Title
From Bhopal to Cold Fusion: A Case-Study Approach to Writing Assignments in Honors General Chemistry.
Creator
Chamely-Wiik, Donna M., Haky, Jerome E., Galin, Jeffrey R.
Date Issued
2012-03-13
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1021_ed101129v_1521555359
Format
Citation
Synthesis and structural characterization of intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease
Title
Synthesis and structural characterization of intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease.
Creator
Chamely-Wiik, Donna M., Florida Atlantic University, Haky, Jerome E., Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
We have synthesized intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease. A synthetic strategy was devised to be more reproducible than the original strategy. We discovered some very interesting chemistry of one of the intermediates produced from this new scheme. We synthesized L-N-(butyloxycarbonyl)-3-(3-hydroxy-ethyl-4-(benzyloxy)-phenyl)alanine benzylester, a compound containing a secondary alcohol moiety that...
Show moreWe have synthesized intermediates towards the preparation of a polyphosphonate ester containing L-dopa for the potential treatment of Parkinson's disease. A synthetic strategy was devised to be more reproducible than the original strategy. We discovered some very interesting chemistry of one of the intermediates produced from this new scheme. We synthesized L-N-(butyloxycarbonyl)-3-(3-hydroxy-ethyl-4-(benzyloxy)-phenyl)alanine benzylester, a compound containing a secondary alcohol moiety that had a unique set of characteristics. Upon reduction of the N-(tert-butyloxycarbonyl)-3-(3-acetyl-4-benzyloxyphenyl)-L-alanine benzylester, which contained a ketone moiety, to produce the secondary alcohol, we discovered that the materials that were formed included a pair of diastereomers of the secondary alcohol, each diastereomer also exhibiting two individually stable conformational isomers. We believe that the conformational isomers were generated by rotation of the C-N bond of the BOC carbamate, and were so stable that they could be separated by HPLC and NMR techniques. Energy optimization studies and molecular modeling techniques were performed using HyperChem, and rotational barrier energy values were calculated for the different conformational isomers for each of the diastereomers. HPLC and NMR techniques were also used to obtain information about these materials. Using the calculated data from these studies, and analyzing the HPLC chromatograms and NMR spectra we were able to fully determine the assignments for the diastereomers and the individual conformational isomers. We discovered that the SS form was synthesized preferentially over the SR form and that in both cases the E conformation was energetically more stable than the Z form. Octanol/water partition coefficient values (Log P0ct) were also determined and compared to L-dopa and dopamine. We concluded that the values for the dimeric compound that we synthesized and many of its potential products of degradation were significantly higher than that for both L-dopa and dopamine. This may be an indication that this material has a higher degree of lipophilicity than L-dopa itself, having more potential to cross the blood brain barrier. We believe that these intermediate materials serve as good indication of how a polyphosphonate ester containing L-dopa would compare as a potential drug for Parkinson's disease.
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Date Issued
2004
PURL
http://purl.flvc.org/fcla/dt/12108
Subject Headings
Parkinson's disease--Treatment, Antiparkinsonian agents, Dopa, Organophosphorus compounds--Synthesis, Chemistry, Analytic
Format
Document (PDF)
Separation and HPLC Analysis of Diastereomers and Rotational Isomers of.
Title
Separation and HPLC Analysis of Diastereomers and Rotational Isomers of.
Creator
Chamely-Wiik, Donna M., Carraher, Charles E., Kamel, George, Haky, Jerome E.
Date Issued
2006-06-10
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1080_10826070600757680_1521555358
Format
Citation
SQER
Title
SQER.
Creator
Chamely-Wiik, Donna M., Haky, Jerome E., Louda, Deborah W., Romance, Nancy
Date Issued
2014-03-11
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1021_ed300689n_1521555360
Format
Citation