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The role of serotonin 5-HT2A receptors in memory and cognition
Title
The role of serotonin 5-HT2A receptors in memory and cognition.
Creator
Zhang, Gongliang, Stackman, Robert W.
Date Issued
2015-10-06
PURL
http://purl.flvc.org/fau/fd/FAUIR000190
Format
Citation
Effects of hippocampal impairment on rodent spatial and non-spatial memory
Title
Effects of hippocampal impairment on rodent spatial and non-spatial memory.
Creator
Rios, Lisa, Lora, Joan C., Zhang, Gongliang, Stackman, Robert W., Graduate College
Date Issued
2011-04-08
PURL
http://purl.flvc.org/fcla/dt/3164769
Subject Headings
Nerve Degeneration, Rodents, Space perception
Format
Document (PDF)
Hippocampal place cell activity influenced by variations of the novel object recognition task in C57BL/6J mice.
Title
Hippocampal place cell activity influenced by variations of the novel object recognition task in C57BL/6J mice.
Creator
Asgeirsdottir, Herborg Nanna, Cohen, Sarah J., Zhang, Gongliang, Munchow, Alcira H., Stackman, Robert W., Graduate College
Date Issued
2013-04-12
PURL
http://purl.flvc.org/fcla/dt/3361265
Subject Headings
Hippocampus (Brain), Neurons, Mice
Format
Document (PDF)
Roles of serotonin 2A receptor in a serotonin syndrome
Title
Roles of serotonin 2A receptor in a serotonin syndrome.
Creator
Zhang, Gongliang, Charles E. Schmidt College of Medicine, Department of Biomedical Science
Abstract/Description
Serotonin (5-HT) is a neurotransmitter in the central nervous system. Decrease in the brain 5-HT level could induce depression, showing a state of low mood, aversion to motion and feeling of worthlessness. About 12 million adults in the United States have depression. Antidepressants, such as monoamine oxidase inhibitors and selective serotonin reuptake inhibitors, can alleviate the depressive mood by increasing the brain's 5-HT activity, however they can also induce a potentially life...
Show moreSerotonin (5-HT) is a neurotransmitter in the central nervous system. Decrease in the brain 5-HT level could induce depression, showing a state of low mood, aversion to motion and feeling of worthlessness. About 12 million adults in the United States have depression. Antidepressants, such as monoamine oxidase inhibitors and selective serotonin reuptake inhibitors, can alleviate the depressive mood by increasing the brain's 5-HT activity, however they can also induce a potentially life-threatening side effect, namely 5-HT syndrome. This syndrome is manifested by neuromuscular hyperactivities, mental disorders and autonomic dysfunctions. Clinical studies have demonstrated that 5-HT2A receptor antagonists could effectively block severe symptoms of patients with the 5-HT syndrome. To understand the underlying mechanisms, in this study we examined the activity of the 5-HT2A receptor in rats with the 5-HT syndrome evoked by a combined injection of clorgyline, a monoamine oxidase inhibitor , and paroxetine, a selective 5-HT reuptake inhibitor. The major findings from my study were that: (1) Chronic clorgyline treatment significantly exacerbated 5-HT2A receptor-mediated symptoms of the 5-HT syndrome animals; (2) The 5-HT2A receptor-mediated symptoms were also aggravated when the 5-HT syndrome animals were housed in warm (32 ÀC) ambient temperature; (3) Blocking 5-HT2A receptors in the medial prefrontal cortex alleviated the 5-HT syndrome through a circuit between raphe serotonergic neurons and medial prefrontal cortex glutamatergic neurons. Taken together, my data demonstrate that the activity of 5-HT2A receptors may be enhanced by chronic antidepressant treatment and warm environmental temperature., The sensitized 5-HT2A receptor in the medial prefrontal cortex may exacerbate the syndrome through a positive-feedback circuit between medial prefrontal cortex and raphe nuclei, which would result in excessive 5-HT in the brain. This study casts a new light on the underlying mechanisms of the 5-HT syndrome.
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Date Issued
2010
PURL
http://purl.flvc.org/FAU/2100576
Subject Headings
Serotonin uptake inhibitors, Therapeutic use, Serotonin uptake inhibitors, Physiological effect, Serotonin, Receptors, Physiological effect, Central nervous system, Physiology, Neurotransmitter receptors, Serotoninergic mechanisms
Format
Document (PDF)