Current Search: Young, Erica (x)
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Title
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Disrupting methamphetamine associated memory by targeting synaptic dynamics.
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Creator
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Zigmond, Zachary, Miller, Courtney, Young, Erica, Quintyne, Nicholas, Harriet L. Wilkes Honors College
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Abstract/Description
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Methamphetamine (METH) is addictive and associated with a high rate of relapse. One relapse trigger is re-experiencing drug-associated contextual associations. Therefore it is possible that, by targeting METH-associated contextual memories, drug seeking behavior can be inhibited. Recent evidence has suggested that memory formation relies on actin polymerization, which allows dendritic spines to undergo structural and functional plasticity, key components of memory. To see if actin...
Show moreMethamphetamine (METH) is addictive and associated with a high rate of relapse. One relapse trigger is re-experiencing drug-associated contextual associations. Therefore it is possible that, by targeting METH-associated contextual memories, drug seeking behavior can be inhibited. Recent evidence has suggested that memory formation relies on actin polymerization, which allows dendritic spines to undergo structural and functional plasticity, key components of memory. To see if actin polymerization could be a target for the extinction of METH seeking memories we inhibited actin polymerization in animals that had been trained in either METH or food associated conditioned place preference. Pretest inhibition of actin cycling in the basolateral amygdala complex produced immediate and persistent extinction of METH seeking behavior. Additionally, inhibiting actin polymerization 24hrs before testing disrupted seeking behavior for METH but not food. These results indicate that METH-associated memories are selectively vulnerable to disruption through inhibition of actin dynamics.
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Date Issued
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2013
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PURL
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http://purl.flvc.org/fau/fd/FA00003542
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Format
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Document (PDF)
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Title
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CELL-TYPE-SPECIFIC CONSOLIDATION OF LEARNED MOTOR MEMORIES IN THE NEOCORTEX.
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Creator
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DiCicco, Rebecca, Young, Erica, Harriet L. Wilkes Honors College, Florida Atlantic University
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Abstract/Description
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Motor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill...
Show moreMotor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill acquisition. This project aims to explore how the brain consolidates the acquired motor skill as a long-term memory. We hypothesize that following motor learning, CaMKII in PT, but not IT, cells activates the expression of immediate early genes (IEGs) arc and cfos, which may play a critical role in the storage of motor memories. Understanding the cell-specific roles in the ALM could provide insights into motor memory neural circuitry and diseases.
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Date Issued
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2024
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PURL
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http://purl.flvc.org/fau/fd/FAUHT00296
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Format
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Document (PDF)
