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Title: Effects of chronic amphetamine on the appetitive and consummatory phases of feeding.
Creator: Wolgin, David L.
Date Issued: 2002-06
PURL: http://purl.flvc.org/fau/228706
Subject Headings: Behavior-drug effects., Neuropharmacology--Research.
Format: Document (PDF)

Title: Contingent tolerance to amphetamine hypophagia: new insights into the role of environmental context in the expression of stereotypy.
Creator: Wolgin, David L.
Date Issued: 2000-05
PURL: http://purl.flvc.org/fau/228668
Subject Headings: Psychopharmocology--Research
Format: Document (PDF)

Title: Cortical KCI reinstates forelimb placing following damage to the internal capsule.
Creator: Wolgin, David L., Kehoe, Priscilla
Date Issued: 1983-08
PURL: http://purl.flvc.org/fau/228749
Subject Headings: Physiology--Research., Drugs Physiological effect
Format: Document (PDF)

Title: Role of activation and sensory stimuli in recovery from lateral hypothalmic damage in the cat.
Creator: Wolgin, David L., Teitelbaum, Philip
Date Issued: 1978-06
PURL: http://purl.flvc.org/fau/228751
Subject Headings: Psychophysiology--Research., Animals, Domestic--Physiology, Neurosciences
Format: Document (PDF)

Title: Contingent tolerance to the anorexigenic effects of amphetamine.
Creator: Wolgin, David L., Carlton, Peter L.
Date Issued: 1971-08
PURL: http://purl.flvc.org/fau/228490
Subject Headings: Psychopharmacology--Research., Appetite depressants., Amphetamines--Physiological effect.
Format: Document (PDF)

Title: Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia.
Creator: Wolgin, David L., Kinney, Gene G.
Date Issued: 1992
PURL: http://purl.flvc.org/fau/226864
Subject Headings: Psychopharmacology--Research, Amphetamines--Physiological effects.
Format: Document (PDF)

Title: Effect of sensitization of stereotyp on the acquisition and retention of tolerance to amphetamine hypophagia.
Creator: Wolgin, David L., Hughes, Katherine M.
Date Issued: 1996-08-01
PURL: http://purl.flvc.org/fau/228562
Subject Headings: Psychopharmacology--Research.
Format: Document (PDF)

Title: Effects of acute and chronic cocaine on milk intake, body weight, and activity in bottle- and cannula-fed rats.
Creator: Wolgin, David L., Hertz, Jacqueline Moore
Date Issued: 1995-01-01
PURL: http://purl.flvc.org/fau/228753
Subject Headings: Behavior--drug effects., Psychopharmacology--Animal models., Psychopharmacology--Research.
Format: Document (PDF)

Title: Changes in behavioural contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued feeding tests while drugged.
Creator: Wolgin, David L., Hughes, Katherine M.
Date Issued: 2002-07
PURL: http://purl.flvc.org/fau/227254
Subject Headings: Psychopharmacology--Research, Animal experimentation., Amphetamines-Physiological effects.
Format: Document (PDF)

Title: Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: instrumental contingencies regulate the expression of sensitization.
Creator: Wolgin, David L., Hughes, Katherine M., Popi, Lavinia
Date Issued: 1998-12-01
PURL: http://purl.flvc.org/fau/226857
Subject Headings: Psychopharmacology--Research., Amphetamines--Physiological effects.
Format: Document (PDF)

Title: Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia.
Creator: Wolgin, David L., Hughes, Katherine M.
Date Issued: 1997-08-01
PURL: http://purl.flvc.org/fau/228486
Subject Headings: Psychopharmacology--Research., Amphetamines--Physiological effects.
Format: Document (PDF)

Title: Role of instrumental learning in tolerance to cathinone hypophagia.
Creator: Wolgin, David L., Munoz, James R.
Date Issued: 2006-04
PURL: http://purl.flvc.org/fau/228492
Subject Headings: Psychopharmacology--Research., Animal Experimentation, Amphetamines--Physiological effects.
Format: Document (PDF)

Title: Tolerance to amphetamine hypophagia: a microstructural analysis of licking behavior in the rat.
Creator: Wolgin, David L., Jakubow, James J.
Date Issued: 2003-02
PURL: http://purl.flvc.org/fau/228480
Subject Headings: Psychopharmacology--Research, Animal experimentation., Amphetamines--Physiological effects.
Format: Document (PDF)

Title: Tolerance to amphetamine hypophagia: a real-time depiction of learning to suppress stereotyped movements in the rat.
Creator: Wolgin, David L., Jakubow, James J.
Date Issued: 2004-06
PURL: http://purl.flvc.org/fau/228478
Subject Headings: Psychopharmacology--Research, Amphetamines--Physiological effects., Animal experimentation.
Format: Document (PDF)

Title: Role of anorexia and behavioral activation in amphetamine-induced suppression of feeding: implications for understanding tolerance.
Creator: Wolgin, David L., Salisbury, Juanita J.
Date Issued: 1985
PURL: http://purl.flvc.org/fau/228483
Subject Headings: Psychopharmacology--Research, Amphetamines--Physiological effects., Animal experimentation.
Format: Document (PDF)

Title: Learned suppression of stereotypy in amphetamine-treated rats: implications for understanding tolerance to amphetamine 'anorexia'.
Creator: Wolgin, David L., Wade, John Vincent
Date Issued: 1995-04
PURL: http://purl.flvc.org/fau/227248
Subject Headings: Psychopharmacology--Research., Amphetamines--Physiological effects., Animal experimentation.
Format: Document (PDF)

Title: Long-term retention of tolerance to amphetamine hypophagia following cessation of drug injections and feeding tests.
Creator: Wolgin, David L., Hughes, Katherine M.
Date Issued: 2001-10
PURL: http://purl.flvc.org/fau/228747
Subject Headings: Psychopharmacology--Research., Amphetamines--Physiological effects., Appetite depressants.
Format: Document (PDF)

Title: Loss of tolerance to amphetamine-induced hypophagia in rats: homeostatic readjustment vs. instrumental learning.
Creator: Wolgin, David L., Hughes, Katherine M., Popi, Lavinia
Date Issued: 1999-09
PURL: http://purl.flvc.org/fau/228632
Subject Headings: Psychopharmacology--Research., Appetite depressants., Amphetamines--Physiological effects.
Format: Document (PDF)

Title: Effects of daily cocaine on milk intake and motor activity in cannula-fed and bottle-fed rats.
Creator: Hertz, Jacqueline Moore, Florida Atlantic University, Wolgin, David L.
Abstract/Description: The purpose of this experiment was to determine if tolerance to cocaine-induced hypophagia involves learning to suppress stereotyped movements that interfere with feeding. Milk intake and motor activity were measured in rats fed via bottles or intraoral cannulas. On dose-response 1, the bottle group was more hypophagic than the cannula group at the 8, 16, and 32 mg/kg doses. After 60d of chronic cocaine (16 mg/kg), only the bottle-fed group showed tolerance, indicated by a shift to the right...
Show moreThe purpose of this experiment was to determine if tolerance to cocaine-induced hypophagia involves learning to suppress stereotyped movements that interfere with feeding. Milk intake and motor activity were measured in rats fed via bottles or intraoral cannulas. On dose-response 1, the bottle group was more hypophagic than the cannula group at the 8, 16, and 32 mg/kg doses. After 60d of chronic cocaine (16 mg/kg), only the bottle-fed group showed tolerance, indicated by a shift to the right on dose-response 2. Tolerance was accompanied by a decrease in activity, while activity in the cannula-fed groups given 16 or 32 mg/kg showed sensitization. These results suggest that moderate doses of cocaine interfere with feeding primarily by producing incompatible behaviors. Tolerance involves learning to inhibit these behaviors in order to feed.
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Date Issued: 1997
PURL: http://purl.flvc.org/fcla/dt/15464
Subject Headings: Rats as laboratory animals, Conditioned response, Drug tolerance
Format: Document (PDF)

Title: Neural Activity Associated with Tolerance to Amphetamine Hypophagia.
Creator: Bachand, Kimberlee D., Wolgin, David L., Florida Atlantic University
Abstract/Description: There is a growing body of literature indicating that drug effects are influenced by the context in which they are taken, and that neuroadaptations resulting from chronic drug use are similarly context dependent. Contingent tolerance to amphetamine-induced hypophagia is mediated by the learned suppression of stereotyped behaviors, and is an example of a drug-environment interaction. This form of behavioral tolerance depends upon instrumental learning, by which rats learn a strategy to...
Show moreThere is a growing body of literature indicating that drug effects are influenced by the context in which they are taken, and that neuroadaptations resulting from chronic drug use are similarly context dependent. Contingent tolerance to amphetamine-induced hypophagia is mediated by the learned suppression of stereotyped behaviors, and is an example of a drug-environment interaction. This form of behavioral tolerance depends upon instrumental learning, by which rats learn a strategy to suppress drug-induced stereotypies that interfere with feeding. Considerable progress has been made in understanding contingent tolerance at the behavioral level; little is known about the neural mechanisms underlying contingent tolerance. Therefore, the purpose of this study was to delineate neural circuitry involved in contingent tolerance. The differential activation of neurons expressing the immediate early gene c-fos was analyzed throughout the brains of amphetamine-tolerant and non-tolerant rats, using the Before-After paradigm; the amphetamine tolerant group received injections of amphetamine (2.0 mg/kg) before access to milk, after-amphetamine and after-saline groups (i.e., nontolerant) received injections of amphetamine after access to milk, and the saline group received saline at both time points. The experimental design permitted us to identify structures uniquely involved in tolerance from those associated with drinking milk, having a history of amphetamine, or receiving an injection of amphetamine on the final test. The unique finding reported here is that when amphetamine is given in an environment containing food, patterns of c-fos are very different than when the drug is given in an environment without food. Results showed that amphetamine-tolerant animals had significant increases in c-fos in a set of interconnected structures throughout the brain, as compared with non-tolerant and saline rats. These data supported the hypothesis that structures associated with the dorsal striatum mediate the response selection of feeding and the inhibition of stereotypies, while the ventral striatum, via instrumental learning, reinforces the selection and inhibition of competing motor behaviors. Results also support the idea that the mechanisms of tolerance involve several neural subsystems that function to modulate motor, motivational, and reward-based learning. Specifically, the learned suppression of stereotypies involves the tolerance "Response Selection," "Reinforcement," and "Instrumental Learning" subsystems.
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Date Issued: 2006
PURL: http://purl.flvc.org/fau/fd/FA00000847
Subject Headings: Amphetamines--Physiological effect, Drug tolerance, Drugs--Physiological effect, Rats as laboratory animals
Format: Document (PDF)

FAU College Collections (20)	+ -
FAU Theses and Dissertations (8)	+ -

Amphetamines--Physiological effects. (10)	+ -
Psychopharmacology--Research. (10)	+ -
Animal experimentation. (7)	+ -
Drug tolerance (6)	+ -
Psychopharmacology--Research (6)	+ -

Amphetamines--Physiological effect (4)	+ -
Drugs--Physiological effect (4)	+ -
Rats as laboratory animals (4)	+ -
Appetite depressants. (3)	+ -
Conditioned response (2)	+ -
Amohetamines--Physiological effects. (1)	+ -
Amphetamines--Physiological effect. (1)	+ -
Amphetamines-Physiological effects. (1)	+ -
Animal Experimentation (1)	+ -
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Appetite--Effect of drugs on (1)	+ -
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Behavior-drug effects. (1)	+ -
Classical conditioning (1)	+ -
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Wolgin, David L. (28)	+ -
Florida Atlantic University (8)	+ -
Hughes, Katherine M. (7)	+ -
Bachand, Kimberlee D. (2)	+ -
Charles E. Schmidt College of Science (2)	+ -

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