Current Search: Wan, Zhongliang (x)
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Title
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Isolation, Characterization and Synthesis of New Diterpenes from Pseudopterogorgia elisabethae.
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Creator
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Wan, Zhongliang, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
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Abstract/Description
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Pseudopterogorgia elisabethae is a known source of structurally interesting bioactive metabolites. A detailed search for new, related compounds was undertaken in this study which resulted in the isolation and characterization of more than ten new diterpenes with serrulatane and ileabethane skeletons. Some of the new compounds isolated are closely related terpenes with significant biological activity and others are likely to be key biosynthetic intermediates. As a component of the development...
Show morePseudopterogorgia elisabethae is a known source of structurally interesting bioactive metabolites. A detailed search for new, related compounds was undertaken in this study which resulted in the isolation and characterization of more than ten new diterpenes with serrulatane and ileabethane skeletons. Some of the new compounds isolated are closely related terpenes with significant biological activity and others are likely to be key biosynthetic intermediates. As a component of the development of a production method of anti-inflammatory compounds such as seco-pseudopterosin and elisabethadione, a synthesis of a seco-pseudoperosin aglycone from elisabethatriene was developed.
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Date Issued
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2006
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PURL
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http://purl.flvc.org/fau/fd/FA00000883
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Subject Headings
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Biosynthesis, Diterpenes--Synthesis, Marine invertebrates, Anti-inflammatory agents
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Format
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Document (PDF)