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The NSAID, Sulindac confers protection against oxidative stress induced damage in retinal pigmented epithelial cells
Title
The NSAID, Sulindac confers protection against oxidative stress induced damage in retinal pigmented epithelial cells.
Creator
Sur, Arunodoy, Biswal, Manas, Kreymerman, Alexander, Weissbach, Herbert, Prentice, Howard, Blanks, Janet C., Graduate College
Date Issued
2011-04-08
PURL
http://purl.flvc.org/fcla/dt/3164798
Subject Headings
Nonsteroidal anti-inflammatory agents, Oxidative stress, Epithelial cells
Format
Document (PDF)
Differential effect of sulindac on normal and malignant retinal cells
Title
Differential effect of sulindac on normal and malignant retinal cells.
Creator
Sur, Arunodoy, Blanks, Janet C., Charles E. Schmidt College of Science, Center for Complex Systems and Brain Sciences
Abstract/Description
Age related macular degeneration (AMD) is the leading cause of blindness among the elderly population and oxidative stress induced damage of ocular tissues is thought to play an important role in the etiology of this disease. This current study is aimed at testing pharmacological preconditioning as a possible protective mechanism for retinal cells against oxidative stress induced damage. Since the retinal pigment epithelial (RPE) cells located adjacent to the photoreceptor cells, are believed...
Show moreAge related macular degeneration (AMD) is the leading cause of blindness among the elderly population and oxidative stress induced damage of ocular tissues is thought to play an important role in the etiology of this disease. This current study is aimed at testing pharmacological preconditioning as a possible protective mechanism for retinal cells against oxidative stress induced damage. Since the retinal pigment epithelial (RPE) cells located adjacent to the photoreceptor cells, are believed to be responsible for the initial pathology in AMD we tested our therapy on this cell type. Earlier research conducted with lung cells and in a cardiac model with the nonsteroidal anti-inflammatory drug (NSAID) sulindac (Moench et al., 2009; Marchetti et al., 2009) indicate that sulindac can protect normal cells from oxidative damage through ischemic preconditioning (IPC) pathways. This led us to test whether sulindac can also protect significant protection against both tert-butyl hydrogen peroxide (TBHP) induced chemical stress and UVB light induced photooxidative damage through a preconditioning mechanism.
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Date Issued
2013
PURL
http://purl.flvc.org/fau/fd/FA00004258
Format
Document (PDF)
Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α
Title
Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.
Creator
Sur, Arunodoy, Kesaraju, Shailaja, Prentice, Howard, Ayyanathan, Kasirajan, Baronas-Lowell, Diane, Zhu, Danhong, Hinton, David R., Blanks, Janet, Weissbach, Herbert
Date Issued
2014-11-10
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1073_pnas.1419576111_1631807081
Format
Citation