Current Search: Rodriguez, Lesbeth Caridad. (x)
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Title
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Chemoenzymatic synthesis of 9,11-secosteroids using an enzyme extract from a marine coral.
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Creator
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Rodriguez, Lesbeth Caridad., Florida Atlantic University, Kerr, Russell G.
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Abstract/Description
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9,11-Secogorgosterol, a secondary metabolite from the gorgonian Pseudopterogorgia americana, exhibits inhibitory activity against protein kinase C, and potent anti-proliferative and anti-inflammatory activity. An efficient method for the production of 9,11-secogorgosterol has been developed and optimized using an enzyme extract from the gorgonian P. americana. The gorgonian also produces two other 9,11-secosteroids which have marked differences in their side chains and nuclei, which suggested...
Show more9,11-Secogorgosterol, a secondary metabolite from the gorgonian Pseudopterogorgia americana, exhibits inhibitory activity against protein kinase C, and potent anti-proliferative and anti-inflammatory activity. An efficient method for the production of 9,11-secogorgosterol has been developed and optimized using an enzyme extract from the gorgonian P. americana. The gorgonian also produces two other 9,11-secosteroids which have marked differences in their side chains and nuclei, which suggested that the enzymes responsible for their production were likely relatively nonspecific. Novel 9,11-secosteroids have been synthesized using the enzyme extract from the gorgonian.
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Date Issued
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1997
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PURL
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http://purl.flvc.org/fcla/dt/15431
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Subject Headings
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Steroids, Enzymes--Synthesis, Alcyonacea, Corals
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Format
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Document (PDF)
