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A study of Caenorhabditis elegans tissue inhibitor of metalloproteinases
Title
A study of Caenorhabditis elegans tissue inhibitor of metalloproteinases.
Creator
Paul, Tamara., Florida Atlantic University, Brew, Keith
Abstract/Description
Tissue Inhibitors of Metalloproteinases (TIMPs) are produced by a wide variety of cell types. Similar to matrixins, the expression of TIMPs in the tissue is also controlled during tissue remodeling and physiological conditions to maintain a balance in the metabolism of extracellular matrix. Disruption of this balance can result in diseases associated with uncontrolled turnover of matrix, such as arthritis, cancer, and cardiovascular disease. Some of the biological processes TIMPs participate...
Show moreTissue Inhibitors of Metalloproteinases (TIMPs) are produced by a wide variety of cell types. Similar to matrixins, the expression of TIMPs in the tissue is also controlled during tissue remodeling and physiological conditions to maintain a balance in the metabolism of extracellular matrix. Disruption of this balance can result in diseases associated with uncontrolled turnover of matrix, such as arthritis, cancer, and cardiovascular disease. Some of the biological processes TIMPs participate in include: regulation of cell morphology and organ morphogenesis, inhibition of angiogenesis, steroidogenesis, and tissue remodeling. One major function of TIMPs is inhibition of Matrix Metaloproteinase (MMPs). This project used bioinformatic techniques to identify two Caenorhabditis elegans TIMP cDNA cloned by BLAST searching of EST database. These TIMP cDNA were amplified, cloned and expressed, proteins were purified. Kinetic studies were carried out to evaluate the inhibitory activities against various MMPs and TACE. This research project will provide some insight on the function of C. elegans TIMPs.
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Date Issued
2006
PURL
http://purl.flvc.org/fcla/dt/13414
Subject Headings
Endopeptidases--Inhibitors, Proteolytic enzymes, Extracellular matrix proteins, Metalloproteinases--Inhibitors
Format
Document (PDF)
Managing Employee Compliance with Information Security Policies: The Critical Role of Top Management and Organizational Culture*
Title
Managing Employee Compliance with Information Security Policies: The Critical Role of Top Management and Organizational Culture*.
Creator
Hu, Qing, Dinev, Tamara, Hart, Paul, Cooke, Donna
Date Issued
2012-05-28
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1111_j.1540-5915.2012.00361.x_1645042538
Format
Document (PDF)
Biomass offsets little or none of permafrost carbon release from soils, streams, and wildfire: an expert assessment
Title
Biomass offsets little or none of permafrost carbon release from soils, streams, and wildfire: an expert assessment.
Creator
Abbott, Benjamin W., Jones, Jeremy B., Schuur, Edward A. G., Chapin III, F. Stuart, Bowden, William B., Bret-Harte, M. Syndonia, Epstein, Howard E., Flannigan, Michael D., Harms, Tamara K., Hollingsworth, Teresa N., Mack, Michelle C., McGuire, A. David, Natali, Susan M., Rocha, Adrian V., Tank, Suzanne E., Turetsky, Merritt R., Vonk, Jorien E., Wickland, Kimberly P., Aiken, George R., Alexander, Heather D., Amon, Rainer M. W., Benscoter, Brian, Bergeron, Yves, Bishop, Kevin, Blarquez, Olivier, Bond-Lamberty, Ben, Breen, Amy L., Buffam, Ishi, Cai, Yihua, Carcaillet, Christopher, Carey, Sean K., Chen, Jing M., Chen, Han Y. H., Christensen, Torben R., Cooper, Lee W., Cornelissen, J. Hans C., de Groot, William J., DeLuca, Thomas H., Dorrepaal, Ellen, Fetcher, Ned, Finlay, Jacques C., Forbes, Bruce C., French, Nancy H. F., Gauthier, Sylvie, Girardin, Martin P., Goetz, Scott J., Goldammer, Johann G., Gough, Laura, Grogan, Paul, Guo, Laodong, Higuera, Philip E., Hinzman, Larry, Hu, Feng Sheng, Hugelius, Gustaf, Jafarov, Elchin E., Jandt, Randi, Johnstone, Jill F., Jan Karlsson, Kasischke, Eric S., Kattner, Gerhard, Kelly, Ryan, Keuper, Frida, Kling, George W., Kortelainen, Pirkko, Kouki, Jari, Kuhry, Peter, Laudon, Hjalmar, Laurion, Isabelle, Macdonald, Robie W., Mann, Paul J., Martikainen, Pertti J., McClelland, James W., Molau, Ulf, Oberbauer, Steven F., Olefeldt, David, Paré, David, Parisien, Marc-André, Payette, Serge, Peng, Changhui, Pokrovsky, Oleg S., Rastetter, Edward B., Raymond, Peter A., Raynolds, Martha K., Rein, Guillermo, Reynolds, James F., Robards, Martin, Rogers, Brendan M., Schädel, Christina, Schaefer, Kevin, Schmidt, Inger K., Shvidenko, Anatoly, Sky, Jasper, Spencer, Robert G. M., Starr, Gregory, Striegl, Robert G., Teisserenc, Roman, Tranvik, Lars J., Virtanen, Tarmo, Welker, Jeffrey M., Zimov, Sergei
Date Issued
2016-03-07
PURL
http://purl.flvc.org/fau/fd/FAUIR000121
Format
Citation
Biomass offsets little or none of permafrost carbon release from soils, streams, and wildfire: an expert assessment
Title
Biomass offsets little or none of permafrost carbon release from soils, streams, and wildfire: an expert assessment.
Creator
Abbott, Benjamin W, Jones, Jeremy B, Schuur, Edward A G, Chapin III, F Stuart, Bowden, William B, Bret-Harte, M Syndonia, Epstein, Howard E, Flannigan, Michael D, Harms, Tamara K, Hollingsworth, Teresa N, Mack, Michelle C, McGuire, A David, Natali, Susan M, Rocha, Adrian V, Tank, Suzanne E, Turetsky, Merritt R, Vonk, Jorien E, Wickland, Kimberly P, Aiken, George R, Alexander, Heather D, Amon, Rainer M W, Benscoter, Brian W, Bergeron, Yves, Bishop, Kevin, Blarquez, Olivier, Ben Bond-Lamberty, Breen, Amy L, Buffam, Ishi, Cai, Yihua, Carcaillet, Christopher, Carey, Sean K, Chen, Jing M, Chen, Han Y H, Christensen, Torben R, Cooper, Lee W, Cornelissen, J Hans C, de Groot, William J, DeLuca, Thomas H, Dorrepaal, Ellen, Fetcher, Ned, Finlay, Jacques C, Forbes, Bruce C, French, Nancy H F, Gauthier, Sylvie, Girardin, Martin P, Goetz, Scott J, Goldammer, Johann G, Gough, Laura, Grogan, Paul, Guo, Laodong, Higuera, Philip E, Hinzman, Larry, Hu, Feng Sheng, Hugelius, Gustaf, Jafarov, Elchin E, Jandt, Randi, Johnstone, Jill F, Jan Karlsson, Kasischke, Eric S, Kattner, Gerhard, Kelly, Ryan, Keuper, Frida, Kling, George W, Kortelainen, Pirkko, Kouki, Jari, Kuhry, Peter, Laudon, Hjalmar, Laurion, Isabelle, Macdonald, Robie W, Mann, Paul J, Martikainen, Pertti J, McClelland, James W, Molau, Ulf, Oberbauer, Steven F, Olefeldt, David, Paré, David, Parisien, Marc-André, Payette, Serge, Peng, Changhui, Pokrovsky, Oleg S, Rastetter, Edward B, Raymond, Peter A, Raynolds, Martha K, Rein, Guillermo, Reynolds, James F, Robards, Martin, Rogers, Brendan M, Schädel, Christina, Schaefer, Kevin, Schmidt, Inger K, Shvidenko, Anatoly, Sky, Jasper, Spencer, Robert G M, Starr, Gregory, Striegl, Robert G, Teisserenc, Roman, Tranvik, Lars J, Virtanen, Tarmo, Welker, Jeffrey M, Zimov, Sergei
Date Issued
2016-03-07
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1088_1748-9326_11_3_034014_1632246943
Format
Citation