Current Search: Nguyen, Matthew (x)
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Title
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Angiographic Changes of Blood Vessels in the Photoreceptor Degenerative Mouse Retina.
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Creator
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Nguyen, Matthew, Shen, Wen, Office of Undergraduate Research and Inquiry
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Abstract/Description
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Tortuous, or twisted, arteries and veins are commonly observed in humans and animals diagnosed with diseases caused by the degeneration of photoreceptor cells. However, the mechanisms of their formation and development are poorly understood. We used immunocytochemical, confocal imaging and computer remodeling techniques to map the angiographic changes in the photoreceptor degenerative mouse model, pde6d (rd1) mice. We found that mechanical instability and rewiring in the distal retina of rd1...
Show moreTortuous, or twisted, arteries and veins are commonly observed in humans and animals diagnosed with diseases caused by the degeneration of photoreceptor cells. However, the mechanisms of their formation and development are poorly understood. We used immunocytochemical, confocal imaging and computer remodeling techniques to map the angiographic changes in the photoreceptor degenerative mouse model, pde6d (rd1) mice. We found that mechanical instability and rewiring in the distal retina of rd1 mice could be mechanisms for the initiation and development of these tortuous vessels. We also found that in the late stages of retinal degeneration, severe tortuosity leads to ischemic attack in the distal retina. This study provides valuable insights into understanding the pathologic changes of retinal blood vessels in the development of diseases in humans and animals.
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Date Issued
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2016
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PURL
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http://purl.flvc.org/fau/fd/FA00005594
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Subject Headings
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College students --Research --United States.
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Format
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Document (PDF)
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Title
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PHOTORECEPTOR DEGENERATION AND ABNORMAL RETINAL VASCULOGENESIS.
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Creator
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Nguyen, Matthew, Shen, Wen, Florida Atlantic University, Department of Biomedical Science, Charles E. Schmidt College of Medicine
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Abstract/Description
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Abnormal vasculature in the retina, specifically tortuous blood vessels, are common to many of the most prevalent retinal degenerative diseases currently affecting millions across the world. The mechanisms of their formation and development in the context of retinal degenerative disease, however, are still poorly understood. The rd1 and rd10 mice are relatively well-studied animal models of retinal degenerative disease, however, there lacks a systematic characterization of vascular changes co...
Show moreAbnormal vasculature in the retina, specifically tortuous blood vessels, are common to many of the most prevalent retinal degenerative diseases currently affecting millions across the world. The mechanisms of their formation and development in the context of retinal degenerative disease, however, are still poorly understood. The rd1 and rd10 mice are relatively well-studied animal models of retinal degenerative disease, however, there lacks a systematic characterization of vascular changes co-related to photoreceptor degeneration in the rd1 and rd10 retina. Here, we utilize advancements in confocal microscopy, immunohistochemistry, and image analysis software in order to systematically characterize vascular changes before and after retinal development in the rd1 and rd10 mice. We show that there are plexus specific changes in the retinal vasculature that parallel photoreceptor degeneration. Such information will be of particular use to future studies investigating the role of vascular changes in retinal degenerative disease therapies.
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Date Issued
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2021
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PURL
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http://purl.flvc.org/fau/fd/FA00013818
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Subject Headings
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Retinal Degeneration, Retinal Vessels--pathology, Retina—Diseases, Photoreceptors
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Format
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Document (PDF)
