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FAU 2016 3MT® Three Minute Thesis Championship Second Runner-Up - Keith Murphy
Title
FAU 2016 3MT® Three Minute Thesis Championship Second Runner-Up - Keith Murphy.
Creator
Murphy, Keith Richard, Graduate College
Abstract/Description
The 3MT® competition celebrates the exciting research conducted by graduate students. Developed by The University of Queensland (UQ), the exercise cultivates students’ academic, presentation, and research communication skills. The competition supports their capacity to effectively explain their research in three minutes, in language appropriate to a non-specialist audience. The first 3MT® competition was held at the University of Queensland in 2008 with 160 students competing. In 2009 and...
Show moreThe 3MT® competition celebrates the exciting research conducted by graduate students. Developed by The University of Queensland (UQ), the exercise cultivates students’ academic, presentation, and research communication skills. The competition supports their capacity to effectively explain their research in three minutes, in language appropriate to a non-specialist audience. The first 3MT® competition was held at the University of Queensland in 2008 with 160 students competing. In 2009 and 2010 the 3MT® competition was promoted to other Australian and New Zealand universities and enthusiasm for the concept grew. Since 2011, the popularity of the competition has increased and 3MT® competitions are now held in over 170 universities across more than 18 countries worldwide.
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00005392
Subject Headings
College students --Research --United States.
Format
Video file
FAU 2017 3MT® Three Minute Thesis Championship First Runner-Up - Keith Murphy
Title
FAU 2017 3MT® Three Minute Thesis Championship First Runner-Up - Keith Murphy.
Creator
Murphy, Keith Richard, Graduate College
Abstract/Description
The 3MT® competition celebrates the exciting research conducted by graduate students. Developed by The University of Queensland (UQ), the exercise cultivates students’ academic, presentation, and research communication skills. The competition supports their capacity to effectively explain their research in three minutes, in language appropriate to a non-specialist audience. The first 3MT® competition was held at the University of Queensland in 2008 with 160 students competing. In 2009 and...
Show moreThe 3MT® competition celebrates the exciting research conducted by graduate students. Developed by The University of Queensland (UQ), the exercise cultivates students’ academic, presentation, and research communication skills. The competition supports their capacity to effectively explain their research in three minutes, in language appropriate to a non-specialist audience. The first 3MT® competition was held at the University of Queensland in 2008 with 160 students competing. In 2009 and 2010 the 3MT® competition was promoted to other Australian and New Zealand universities and enthusiasm for the concept grew. Since 2011, the popularity of the competition has increased and 3MT® competitions are now held in over 170 universities across more than 18 countries worldwide.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00005420
Format
Video file
Core clock genes modulate the sleep-feeding axis
Title
Core clock genes modulate the sleep-feeding axis.
Creator
Murphy, Keith Richard, Bruce, Kimberly, Dawson-Scully, Ken, Graduate College, Ja, William W.
Abstract/Description
Sleep and feeding are processes essential to nearly all complex organisms, impacting the behavioral output of an animal through homeostatic drive. In Drosophila melanogaster it has been shown that starvation leads to sleep suppression through the signaling of core clock proteins that regulate the animal circadian rhythm. Furthermore overexpression of short neuropeptide, a sleep-promoting inhibitory modulator, increases sleep in animals and alters feeding behavior. While these findings provide...
Show moreSleep and feeding are processes essential to nearly all complex organisms, impacting the behavioral output of an animal through homeostatic drive. In Drosophila melanogaster it has been shown that starvation leads to sleep suppression through the signaling of core clock proteins that regulate the animal circadian rhythm. Furthermore overexpression of short neuropeptide, a sleep-promoting inhibitory modulator, increases sleep in animals and alters feeding behavior. While these findings provide a framework of the interaction between the pressures to feed and sleep, they are bi-modal shifts, limiting the understanding of this relationship between to its extreme states. Using the Activity Recording CAFÉ ARC, a tool for measuring the sleep and feeding of individual flies, we tuned either behavior and observed corresponding effects. By shifting food concentrations we are able to control hunger state of an animal while recording its sleep and activity patterns. By coupling this system with a gentle air puff we were also able to control sleep while measuring feeding. We found that the hunger state of an animal had a direct effect on sleep and sleep consolidation. Conversely, we show that increasing sleep pressure led to increased feeding and reduced satiety as calculated through the animal’s prandial behavior. In addition, we show that the direct relationship of the sleep/feeding is disrupted by core clock gene mutations but not by secondary clock genes such as period. By use of the ARC and bi-directional perturbation, we provide a higher resolution understanding of the sleep-feeding axis.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00005843
Format
Document (PDF)
Genetic and Neuronal Integration of Sleep and Feeding
Title
Genetic and Neuronal Integration of Sleep and Feeding.
Creator
Murphy, Keith Richard, Ja, William W., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
Accumulating evidence points to a fundamental connection between sleep and feeding behavior. However, the temporal, genetic, and neuronal architecture that defines these relationships is poorly understood. Drosophila are amenable to high-throughput studies and offer numerous genetic tools which have advanced our understanding of the mechanistic relationships between these behaviors. However, certain features of the sleep-feeding axis have remained elusive, largely due to the separate...
Show moreAccumulating evidence points to a fundamental connection between sleep and feeding behavior. However, the temporal, genetic, and neuronal architecture that defines these relationships is poorly understood. Drosophila are amenable to high-throughput studies and offer numerous genetic tools which have advanced our understanding of the mechanistic relationships between these behaviors. However, certain features of the sleep-feeding axis have remained elusive, largely due to the separate measurement of sleep and feeding. Here, I develop a system which simultaneously measures sleep and feeding in individual animals by employing high resolution machine vision tracking and micro-controller interface functionality. Using this system, I show that food consumption drives a transient rise in sleep, which depends on food quality, quantity, and timing of a meal. The leucokinin system mediates these effects, particularly in response to protein ingestion. We further use the system to examine sleep homeostasis and demonstrate sleep dependence on energy expenditure and fat-brain communication. Collectively, these findings provide novel insight into the fundamental connections between sleep and feeding behavior.
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Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FA00005972
Subject Headings
Sleep, Feeding, Drosophila
Format
Document (PDF)