Current Search: Minnerly, Christopher (x)
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Title
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The Effect of Inactivation of the Nucleus Reuniens on Spatial Working Memory.
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Creator
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Martinez Rey, Macarena, Minnerly, Christopher, Vertes, Robert P., Office of Undergraduate Research and Inquiry
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Abstract/Description
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The Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested...
Show moreThe Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested Long Evan rats using a T-maze. For each trial the rats were required to alternate between the left and right goal arms with a delay period in between randomized intervals of 30s, 60s, or 120s. After two consecutive testing days of 80% the rats were infused with muscimol procaine, and saline. We expect that the effect of reversible inactivation of RE will demonstrate a significant decline in performance of the task.
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Date Issued
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2016
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PURL
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http://purl.flvc.org/fau/fd/FA00005588
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Subject Headings
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College students --Research --United States.
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Format
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Document (PDF)
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Title
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EEG Topographic Changes in Opioid Use Disorder.
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Creator
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Minnerly, Christopher, Tao, Rui, Florida Atlantic University, Department of Biomedical Science, Charles E. Schmidt College of Medicine
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Abstract/Description
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The present study aimed at quantifying the topographic distribution of spectral power as measured with electroencephalogram (EEG) in patients with opioid use disorder (OUD) across five broad band frequencies (δ, θ, α, β, and γ). Through comparative groups of healthy controls, patients with methamphetamine use disorder, and patients with alcohol use disorder, it was determined that OUD EEG spectral power was globally increased in the δ frequency, and more region-specific in others (frontal...
Show moreThe present study aimed at quantifying the topographic distribution of spectral power as measured with electroencephalogram (EEG) in patients with opioid use disorder (OUD) across five broad band frequencies (δ, θ, α, β, and γ). Through comparative groups of healthy controls, patients with methamphetamine use disorder, and patients with alcohol use disorder, it was determined that OUD EEG spectral power was globally increased in the δ frequency, and more region-specific in others (frontal lobes in θ and β frequencies). α frequency was reduced in occipital lobes in OUD. The observed changes are discussed in terms of the microcircuit-level changes in the cortex. Based on these findings, EEG may prove to be a valuable tool for diagnostic and prognostic evaluation of OUD.
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Date Issued
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2020
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PURL
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http://purl.flvc.org/fau/fd/FA00013488
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Subject Headings
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Opioid-Related Disorders, Electroencephalography, Brain Mapping
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Format
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Document (PDF)
