Current Search: Martinez Rey, Macarena (x)
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Title
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The Effect of Inactivation of the Nucleus Reuniens on Spatial Working Memory.
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Creator
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Martinez Rey, Macarena, Minnerly, Christopher, Vertes, Robert P., Office of Undergraduate Research and Inquiry
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Abstract/Description
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The Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested...
Show moreThe Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested Long Evan rats using a T-maze. For each trial the rats were required to alternate between the left and right goal arms with a delay period in between randomized intervals of 30s, 60s, or 120s. After two consecutive testing days of 80% the rats were infused with muscimol procaine, and saline. We expect that the effect of reversible inactivation of RE will demonstrate a significant decline in performance of the task.
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Date Issued
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2016
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PURL
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http://purl.flvc.org/fau/fd/FA00005588
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Subject Headings
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College students --Research --United States.
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Format
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Document (PDF)
