Current Search: Liu, Huan (x)
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Title
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Neurotrophin-3 synthesized by olfactory sensory neurons is anterogradely transported to axon terminals in the olfactory bulb.
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Creator
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Liu, Huan, Graduate College
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Date Issued
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2012-03-30
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PURL
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http://purl.flvc.org/fcla/dt/3342398
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Format
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Document (PDF)
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Title
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Analyses of neuronal replacement in the neuron-depleted olfactory systems in adult mice.
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Creator
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Liu, Huan, Charles E. Schmidt College of Medicine
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Abstract/Description
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New neurons are continuously generated in the olfactory system of adult mice, including olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) and interneurons, produced in the subventricular zone (SVZ) and migrated toward olfactory bulb (OB) along rostral migratory stream (RMS). The present study observed the effects of target neuron loss on the life-span and maturation of adult-born OSNs in the OE and on the proliferation, migration and differentiation of SVZ stem cells in the...
Show moreNew neurons are continuously generated in the olfactory system of adult mice, including olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) and interneurons, produced in the subventricular zone (SVZ) and migrated toward olfactory bulb (OB) along rostral migratory stream (RMS). The present study observed the effects of target neuron loss on the life-span and maturation of adult-born OSNs in the OE and on the proliferation, migration and differentiation of SVZ stem cells in the forebrain after eliminating bulb neurons. We found the life-span of newborn neurons in the absence of synaptic targets was shortened, but the timing of maturation was not delayed. In addition, SVZ cells continued to divide and migrate to the damaged bulb, and the migration of newborn cells in the RMS on the contralateral side was delayed at 2 weeks post-BrdU. Also, the proliferation of cells in dentate gyrus of the hippocampus was not affected by OB damage at 3 weeks post-lesion, though lesion affects occurred in the adult SVZ/RMS.
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Date Issued
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2008
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PURL
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http://purl.flvc.org/fcla/dt/172671
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Subject Headings
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Mice as laboratory animals, Neurotransmitter receptors, Sensory neurons, Testing, Cellular control mechanisms
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Format
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Document (PDF)
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Title
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Anterograde trophic signaling in the olfactory system: neurotrophin-3 expressed by olfactory sensory neurons is transported to target bulb neurons in adult mice.
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Creator
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Liu, Huan, Guthrie, Kathleen M., Charles E. Schmidt College of Science, Department of Biological Sciences
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Abstract/Description
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The adult rodent olfactory system provides an excellent model for the study of the developing nervous system due to its constant integration of new neurons and establishment of new synapses throughout life. This allows for adaptive structural responses to sensory experience that continuously shape functional circuits to fit the behavioral needs of the animal. The cellular mechanisms underlying the anatomical plasticity of the adult olfactory system are not well understood, but neurotrophins,...
Show moreThe adult rodent olfactory system provides an excellent model for the study of the developing nervous system due to its constant integration of new neurons and establishment of new synapses throughout life. This allows for adaptive structural responses to sensory experience that continuously shape functional circuits to fit the behavioral needs of the animal. The cellular mechanisms underlying the anatomical plasticity of the adult olfactory system are not well understood, but neurotrophins, long recognized as crucial to the early development of neuronal circuits, are attractive candidate molecules in this capacity. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), two members of the neurotrophin family, have received attention in terms of their anatomical distribution and physiological functions in the olfactory system.
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Date Issued
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2012
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PURL
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http://purl.flvc.org/fau/fd/FA00004255
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Format
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Document (PDF)
