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Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia
Title
Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia.
Creator
Wolgin, David L., Kinney, Gene G.
Date Issued
1992
PURL
http://purl.flvc.org/fau/226864
Subject Headings
Psychopharmacology--Research, Amphetamines--Physiological effects.
Format
Document (PDF)
Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm
Title
Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm.
Creator
Kinney, Gene G., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Psychology
Abstract/Description
Available evidence suggests that the median raphe nucleus (MRN), when activated, produces a desynchronized hippocampal electroencephalog ram (EEG), and that this effect is sensitive to serotonergic (5-HT) manipulations. Experiment 1 examined the effect of injections into the MRN of agents that non-specifically (procaine) or selectively (8-OH-DPAT and buspirone) inhibit serotonin-containing MRN neurons. These substances produced hippocampal theta rhythm at short latencies and for long...
Show moreAvailable evidence suggests that the median raphe nucleus (MRN), when activated, produces a desynchronized hippocampal electroencephalog ram (EEG), and that this effect is sensitive to serotonergic (5-HT) manipulations. Experiment 1 examined the effect of injections into the MRN of agents that non-specifically (procaine) or selectively (8-OH-DPAT and buspirone) inhibit serotonin-containing MRN neurons. These substances produced hippocampal theta rhythm at short latencies and for long durations, suggesting that MRN 5-HT neurons are specifically responsible for controlling the hippocampal EEG. MRN 5-HT neurons are modulated by a facilitatory excitatory amino acid (EAA) input and an inhibitory influence from GABAergic interneurons within the MRN. Experiments 2 and 3 examined the effect of manipulations of these systems on the hippocampal EEG. Experiment 2 demonstrated that injections of the specific (AP-7) and non-specific (MK-801) NMDA antagonists, as well as the kainate/quisqualate antagonist (GAMS) into the MRN produce theta at short latencies and for long durations. Experiment 3 demonstrated that injections of the GABA$\sb{\rm A}$ agonist, muscimol, into the MRN produced hippocampal theta rhythm at short latencies and for long durations. In light of recent evidence suggesting a theta-pacemaker role for numerous brain nuclei, experiment 4 sought to re-examine the role of the medial septum/diagonal band complex (MS/DB) in hippocampal theta rhythm produced by injections of 8-OH-DPAT into the MRN. Four categories of MS/DB neurons were described: (1) cells which burst rhythmically with theta (rhythmical); (2) cells displaying a tonic increase in discharge with theta (theta-on); (3) cells displaying a dramatic decrease or cessation of discharge with theta (theta-off); and (4) cells which showed no changes in discharge in relation to theta (no-change). It was shown that injections of 8-OH-DPAT into the MRN caused a change in discharge of rhythmic MS/DB cells from an irregular non-bursting pattern during baseline conditions to a rhythmical, bursting pattern which was highly coherent with the hippocampal EEG.
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Date Issued
1994
PURL
http://purl.flvc.org/fcla/dt/12364
Subject Headings
Biology, Neuroscience, Health Sciences, Pharmacology, Biology, Animal Physiology
Format
Document (PDF)
Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine induced hypophagia
Title
Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine induced hypophagia.
Creator
Kinney, Gene G., Florida Atlantic University, Wolgin, David L., Charles E. Schmidt College of Science, Department of Psychology
Abstract/Description
It was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is,...
Show moreIt was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is, sensitized animals were not impaired on milk intake, whereas nonsensitized animals became more sensitive to the hypophagic effect of amphetamine. Further, it was found that animals sensitized to the stereotyped behavioral effects of the drug developed tolerance to this effect, and this tolerance was found to occur both in the presence and absence of milk.
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Date Issued
1992
PURL
http://purl.flvc.org/fcla/dt/14792
Subject Headings
Drug tolerance, Drugs--Physiological effect, Amphetamines--Physiological effect
Format
Document (PDF)