Current Search: Kehoe, Priscilla (x)
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Title
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Cortical KCI reinstates forelimb placing following damage to the internal capsule.
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Creator
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Wolgin, David L., Kehoe, Priscilla
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Date Issued
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1983-08
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PURL
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http://purl.flvc.org/fau/228749
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Subject Headings
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Physiology--Research., Drugs Physiological effect
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Format
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Document (PDF)
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Title
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REVERSAL OF FORELIMB PLACING DEFICITS WITH CORTICAL SPREADING DEPRESSION.
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Creator
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Kehoe, Priscilla, Florida Atlantic University, Wolgin, David L., Charles E. Schmidt College of Science, Department of Psychology
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Abstract/Description
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Rats with lesions of the ventromedial aspect of the internal capsule in the vicinty of the entopeduncular nucleus (EP) showed a loss of forelimb placing (chin, contact and visual) in the contralateral limb. Spreading depression induced by instillation of KCl (25%) to the cortex contralateral to the lesion brought back placing in the affected limb and abolished placing in the normal limb. Within 24 hours the pre-spreading depression state returned and the impaired limb no longer placed while...
Show moreRats with lesions of the ventromedial aspect of the internal capsule in the vicinty of the entopeduncular nucleus (EP) showed a loss of forelimb placing (chin, contact and visual) in the contralateral limb. Spreading depression induced by instillation of KCl (25%) to the cortex contralateral to the lesion brought back placing in the affected limb and abolished placing in the normal limb. Within 24 hours the pre-spreading depression state returned and the impaired limb no longer placed while the normal limb recovered function. In contrast, KCl on the ipsilateral cortex did not reinstate placing. These results suggest that the loss of placing following lesions of the EP are due to tonic inhibition from the cortex contralateral to the lesion. Sensory summation was evident during the early recovery period when placing was accomplished only if two kinds of stimuli were provided simultaneously. Forelimb placing recovered to its pre-lesion state.
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Date Issued
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1981
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PURL
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http://purl.flvc.org/fcla/dt/14078
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Subject Headings
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Rats--Physiology, Neural circuitry
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Format
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Document (PDF)