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Subcellular localization of p21-activated Kinase 6 (PAK6)
Title
Subcellular localization of p21-activated Kinase 6 (PAK6).
Creator
John, Ciny, Graduate College
Date Issued
2012-03-30
PURL
http://purl.flvc.org/fcla/dt/3342384
Format
Document (PDF)
Determining the subcellular localization of a group II p21-activated kinase - PAK6
Title
Determining the subcellular localization of a group II p21-activated kinase - PAK6.
Creator
John, Ciny, Charles E. Schmidt College of Medicine, Department of Biomedical Science
Abstract/Description
p-21-activated kinase 6 (PAK6) is a serine-threonine protein kinase originally identified as an Androgen Receptor (AR) interacting protein. In current study, we determined the subcellular localization of PAK6 through mutational analysis. We have found that the N-terminal CRIB domain is partly responsible for plasma membrane targeting, the region between amino acid residues #292 to #368 is functionally relevant to plasma membrane localization and that amino acid residues #119 through #190 are...
Show morep-21-activated kinase 6 (PAK6) is a serine-threonine protein kinase originally identified as an Androgen Receptor (AR) interacting protein. In current study, we determined the subcellular localization of PAK6 through mutational analysis. We have found that the N-terminal CRIB domain is partly responsible for plasma membrane targeting, the region between amino acid residues #292 to #368 is functionally relevant to plasma membrane localization and that amino acid residues #119 through #190 are responsible for nuclear targeting of PAK6, in addition to a stretch of positively charged N-terminal residues (#2-#11) since mutants lacking this sequence mis-localizes to cytoplasm. In junction forming epithelial cells, PAK6 is demonstrated to co-localize with B-catenin at adherens junctions, suggesting that PAK6 is an activation-dependent event and that PAK6 translocates from plasma membrane to the cytoplasm in response activation via the PKA signal pathway.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3355569
Subject Headings
Cellular signal transduction, Serine proteinases, Phosphorylation, Protein kinases, Pathophysiology, Phosphoroproteins, Metabolism
Format
Document (PDF)
Direct Interaction between AR and PAK6 in Androgen-Stimulated PAK6 Activation
Title
Direct Interaction between AR and PAK6 in Androgen-Stimulated PAK6 Activation.
Creator
Liu, Xia, Busby, Jennifer, John, Ciny, Wei, Jianning, Yuan, Xin, Lu, Michael L., Kyprianou, Natasha
Date Issued
2013-10-10
PURL
http://purl.flvc.org/fau/fd/FAUIR000105
Format
Citation
HISTAMINERGIC AND NOCICEPTIVE GROOMING IN DROSOPHILA MELANOGASTER: AN ANALYSIS OF THE MOLECULAR MECHANISMS AND A BEHAVIORAL RESPONSE TO NOXIOUS CHEMICAL STIMULI
Title
HISTAMINERGIC AND NOCICEPTIVE GROOMING IN DROSOPHILA MELANOGASTER: AN ANALYSIS OF THE MOLECULAR MECHANISMS AND A BEHAVIORAL RESPONSE TO NOXIOUS CHEMICAL STIMULI.
Creator
John, Ciny, Dawson-Scully, Ken, Murphey, Rodney, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
Insect grooming has various functions, including defense against parasites and pathogens, cleaning of dust particles, and maintenance of sensory receptors. The hierarchy of grooming behavior suggests that cleaning one body part is more crucial than the other, the priority order more specifically being eyes, antennae, abdomen, then wings, followed by the thorax. Histamine is an extensively studied neurotransmitter found in the central nervous system of many animals. In Drosophila, histamine is...
Show moreInsect grooming has various functions, including defense against parasites and pathogens, cleaning of dust particles, and maintenance of sensory receptors. The hierarchy of grooming behavior suggests that cleaning one body part is more crucial than the other, the priority order more specifically being eyes, antennae, abdomen, then wings, followed by the thorax. Histamine is an extensively studied neurotransmitter found in the central nervous system of many animals. In Drosophila, histamine is found in both the peripheral and central nervous systems and is necessary for visual and mechanosensory behaviors. Histamine-gated chloride channel 1 (HisCl1) and Ora transientless (Ort) are two characterized histamine receptors, both of which are vital for visual signaling in the fly.
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Date Issued
2019
PURL
http://purl.flvc.org/fau/fd/FA00013321
Subject Headings
Drosophila melanogaster, Grooming behavior in animals, Nociception, Histaminergic mechanisms
Format
Document (PDF)