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Dose-dependent arrhythmia and cardiac dysfunction in restrictive cardiomyopathy mice due to troponin mutations
Title
Dose-dependent arrhythmia and cardiac dysfunction in restrictive cardiomyopathy mice due to troponin mutations.
Creator
Li, Yuejin, Jean-Charles, Pierre-Yves, Nan, Changlong, Chen, Guozhen, Graduate College, Huang, Xupei
Date Issued
2011-04-08
PURL
http://purl.flvc.org/fcla/dt/3164611
Subject Headings
Arrhythmia --drug therapy, Heart failure, Proteomics
Format
Document (PDF)
Mechanism and treatment of restrictive cardiomyopathy
Title
Mechanism and treatment of restrictive cardiomyopathy.
Creator
Jean-Charles, Pierre-Yves, Charles E. Schmidt College of Medicine, Department of Biomedical Science
Abstract/Description
Restrictive cardiomyopathy (RCM) is a cardiac muscle disorder characterized by increased ventricular stiffness and diastolic dysfunction. Patients with RCM often present severe cardiac problems which usually lead to heart failure and sudden death. No effective treatment is available for RCM which makes the finding of novel efficient therapies an urgent necessity. Great progress in molecular biology techniques and advances in transgenic animal development provide great opportunities for the...
Show moreRestrictive cardiomyopathy (RCM) is a cardiac muscle disorder characterized by increased ventricular stiffness and diastolic dysfunction. Patients with RCM often present severe cardiac problems which usually lead to heart failure and sudden death. No effective treatment is available for RCM which makes the finding of novel efficient therapies an urgent necessity. Great progress in molecular biology techniques and advances in transgenic animal development provide great opportunities for the study of RCM and other cardiovascular diseases encountered in clinical patients.... Our laboratory is among the first to generate transgenic mouse models of RCM based on cardiac troponin I (cTnI) missense mutations. In this study, transgenic mice that suffer from RCM have been generated to understand the factors behind the diastolic dysfunction associated with that myocardial disease.... The information obtained from this study allows a better understanding of the role of troponin in RCM and the factors behind the physiopathology of the disease. It will also offer a therapeutic strategy taking into account the physiological characteristic of RCM.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3358554
Subject Headings
Biochemical markers -- Diagnostic use, Cardiovascular system -- Pathophysiology, Coronary heart disease -- Molecular diagnosis, Mice as laboratory animals, Molecular biology
Format
Document (PDF)
N-terminal truncated cardiac TnI improves cardiac function in vivo and rescues restrictive cardiomyopathy
Title
N-terminal truncated cardiac TnI improves cardiac function in vivo and rescues restrictive cardiomyopathy.
Creator
Jean-Charles, Pierre-Yves, Li, Yuejin, Nan, Changlong, Chen, Guozhen, Feng, H., Huang, Xupei, Jin, J.P., Graduate College
Date Issued
2011-04-08
PURL
http://purl.flvc.org/fcla/dt/3164515
Subject Headings
Cardiac arrest, Troponin --diagnostic use, Transgenic mice
Format
Document (PDF)