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Effect of sensitization of stereotyp on the acquisition and retention of tolerance to amphetamine hypophagia
Title
Effect of sensitization of stereotyp on the acquisition and retention of tolerance to amphetamine hypophagia.
Creator
Wolgin, David L., Hughes, Katherine M.
Date Issued
1996-08-01
PURL
http://purl.flvc.org/fau/228562
Subject Headings
Psychopharmacology--Research.
Format
Document (PDF)
Changes in behavioural contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued feeding tests while drugged
Title
Changes in behavioural contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued feeding tests while drugged.
Creator
Wolgin, David L., Hughes, Katherine M.
Date Issued
2002-07
PURL
http://purl.flvc.org/fau/227254
Subject Headings
Psychopharmacology--Research, Animal experimentation., Amphetamines-Physiological effects.
Format
Document (PDF)
Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: instrumental contingencies regulate the expression of sensitization
Title
Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: instrumental contingencies regulate the expression of sensitization.
Creator
Wolgin, David L., Hughes, Katherine M., Popi, Lavinia
Date Issued
1998-12-01
PURL
http://purl.flvc.org/fau/226857
Subject Headings
Psychopharmacology--Research., Amphetamines--Physiological effects.
Format
Document (PDF)
Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia
Title
Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia.
Creator
Wolgin, David L., Hughes, Katherine M.
Date Issued
1997-08-01
PURL
http://purl.flvc.org/fau/228486
Subject Headings
Psychopharmacology--Research., Amphetamines--Physiological effects.
Format
Document (PDF)
Long-term retention of tolerance to amphetamine hypophagia following cessation of drug injections and feeding tests
Title
Long-term retention of tolerance to amphetamine hypophagia following cessation of drug injections and feeding tests.
Creator
Wolgin, David L., Hughes, Katherine M.
Date Issued
2001-10
PURL
http://purl.flvc.org/fau/228747
Subject Headings
Psychopharmacology--Research., Amphetamines--Physiological effects., Appetite depressants.
Format
Document (PDF)
Loss of tolerance to amphetamine-induced hypophagia in rats: homeostatic readjustment vs. instrumental learning
Title
Loss of tolerance to amphetamine-induced hypophagia in rats: homeostatic readjustment vs. instrumental learning.
Creator
Wolgin, David L., Hughes, Katherine M., Popi, Lavinia
Date Issued
1999-09
PURL
http://purl.flvc.org/fau/228632
Subject Headings
Psychopharmacology--Research., Appetite depressants., Amphetamines--Physiological effects.
Format
Document (PDF)
Measurement of Cognitive Function using the CANT AB Neuropsychological Battery in Current and Previous Human Ecstasy (MDMA) Users: A Polydrug Control Study
Title
Measurement of Cognitive Function using the CANT AB Neuropsychological Battery in Current and Previous Human Ecstasy (MDMA) Users: A Polydrug Control Study.
Creator
Paz, Andres L., Hughes, Katherine M., Florida Atlantic University
Abstract/Description
Widespread use of the illicit drug ecstasy (MDMA or 3,4- Methylenedioxymethamphetarnine) and the possible neurological damage caused by its abuse is disconcerting. This study examined possible cognitive impairments in ecstasy users while controlling for polydrug use. The CANT AB neuropsychological tests was used to test working memory capacity, immediate and delayed perceptual matching, shifting of attention, episodic memory, and learning in current and previous ecstasy users compared to non...
Show moreWidespread use of the illicit drug ecstasy (MDMA or 3,4- Methylenedioxymethamphetarnine) and the possible neurological damage caused by its abuse is disconcerting. This study examined possible cognitive impairments in ecstasy users while controlling for polydrug use. The CANT AB neuropsychological tests was used to test working memory capacity, immediate and delayed perceptual matching, shifting of attention, episodic memory, and learning in current and previous ecstasy users compared to non-ecstasy polydrug users. The prediction that current and heavy previous ecstasy users would perform worse on the neuropsychological tests, when compared to polydrug control group, denoting neurological damage was not confirmed. The previous light ecstasy users' performance was also equivalent to the poly drug control group, suggesting that excessive ecstasy use is required to reveal cognitive impairments .. The results suggest that the amount of ecstasy consumed by the participants did not lead to cognitive impairments in the brain regions investigated and supports a 'moderation idea'.
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Date Issued
2006
PURL
http://purl.flvc.org/fau/fd/FA00000805
Subject Headings
Ecstasy (Drug)--Psychological effect, Designer drugs--Physiological effect, Drugs of abuse--Physiological effect, Attachment behavior--Case studies
Format
Document (PDF)
Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia
Title
Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia.
Creator
Hughes, Katherine M., Florida Atlantic University, Wolgin, David L.
Abstract/Description
The purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was...
Show moreThe purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was available. After a 4 wk drug withdrawal period, both groups lost tolerance and displayed more intense stereotypy than they had prior to drug withdrawal. Therefore, sensitization of stereotypy did not retard the development of tolerance. However, the loss of tolerance following drug withdrawal may have been due to the development of more intense stereotypy and/or the "unlearning" of previously acquired strategies for suppressing stereotypy.
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Date Issued
1996
PURL
http://purl.flvc.org/fcla/dt/15287
Subject Headings
Drug tolerance, Drugs--Physiological effect, Amphetamines--Physiological effect
Format
Document (PDF)
Behavioral contingencies, not pharmacological exposure, determine the development, loss and retention of tolerance to amphetamine hypophagia
Title
Behavioral contingencies, not pharmacological exposure, determine the development, loss and retention of tolerance to amphetamine hypophagia.
Creator
Hughes, Katherine M., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Psychology
Abstract/Description
The purpose of this study was to determine whether behavioral contingencies or pharmacological exposure governs the development, loss and retention of tolerance to amphetamine-induced hypophagia in rats. In Experiment 1, rats that had developed tolerance by learning to suppress stereotypy that interfered with feeding from a bottle were divided into three groups to test the retention of tolerance. The Before group received injections of amphetamine (2.0 mg/kg) before access to milk, the After...
Show moreThe purpose of this study was to determine whether behavioral contingencies or pharmacological exposure governs the development, loss and retention of tolerance to amphetamine-induced hypophagia in rats. In Experiment 1, rats that had developed tolerance by learning to suppress stereotypy that interfered with feeding from a bottle were divided into three groups to test the retention of tolerance. The Before group received injections of amphetamine (2.0 mg/kg) before access to milk, the After group received injections of amphetamine after access to milk, and the Saline group received injections of saline before access to milk. Both the After and Saline groups lost tolerance when later tested with amphetamine before milk tests. Thus, the loss of tolerance was not a function of drug withdrawal, because drug exposure remained constant in the After group. When milk reward was obtained noncontingently, tolerance was lost even though pharmacological exposure was maintained. Behavioral strategies that were learned while intoxicated were replaced with new learning when the contingencies were changed. Experiment 2 determined that tolerance loss was a function of new learning and not simply ingesting milk in the unintoxicated state. Bottle-fed tolerant rats were given amphetamine prior to intraoral feeding of milk during a retention interval. Subsequent testing with amphetamine in the bottle condition revealed that tolerance was lost. Because the cannula feeding condition does not require suppression of stereotypy, milk reward was available noncontingently in the intoxicated state and tolerance was lost even though drug exposure was maintained. In Experiment 3 rats were given chronic amphetamine injections and intraoral feeding. Subsequent tests with amphetamine and bottle feeding revealed that no tolerance developed. These results demonstrate that even when ingestion occurs in the intoxicated state, no tolerance develops if milk reward is available noncontingently. Animals that drank intraorally were not tolerant when tested in the bottle condition.
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Date Issued
2000
PURL
http://purl.flvc.org/fcla/dt/12659
Subject Headings
Psychology, Psychobiology, Psychology, Behavioral, Health Sciences, Pharmacology, Psychology, Experimental
Format
Document (PDF)