Current Search: Horowitz, Andrew (x)
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Title
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Exploring cation-π interactions in a sophomore Organic Chemistry Laboratory experiment.
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Creator
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Horowitz, Andrew, Rucco, Dominic, St. Germain, Elijah, Lepore, Salvatore D., Rezler, Evonne
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Abstract/Description
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An Organic Chemistry Lab experiment is being developed and adapted from work recently published by Maity and Lepore [1] investigating the cyclization of substituted β-alkynyl hydrazines to yield azaproline derivatives. The mechanism of this reaction is putatively driven by cation-π interaction of alkynyl hydrazine with a tetrabutylammonium ion. This experiment will present students with a cutting-edge research concept to explore the role of tetrabutylammonium in the cyclization of substituted...
Show moreAn Organic Chemistry Lab experiment is being developed and adapted from work recently published by Maity and Lepore [1] investigating the cyclization of substituted β-alkynyl hydrazines to yield azaproline derivatives. The mechanism of this reaction is putatively driven by cation-π interaction of alkynyl hydrazine with a tetrabutylammonium ion. This experiment will present students with a cutting-edge research concept to explore the role of tetrabutylammonium in the cyclization of substituted β-alkynyl hydrazines. Reaction kinetics will be probed by thin-layer chromatography and azaproline derivative product(s) will be characterized by IR spectroscopy. Ultimately, our goal is to implement a modern research-based, cost-effective, and safe bioorganic experiment into Florida Atlantic University’s undergraduate Organic Chemistry Laboratory curriculum.
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Date Issued
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2014
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PURL
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http://purl.flvc.org/fau/fd/FA0005024
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Subject Headings
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College students --Research --United States.
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Format
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Document (PDF)
