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Effects of acute and chronic cocaine on milk intake, body weight, and activity in bottle- and cannula-fed rats
Title
Effects of acute and chronic cocaine on milk intake, body weight, and activity in bottle- and cannula-fed rats.
Creator
Wolgin, David L., Hertz, Jacqueline Moore
Date Issued
1995-01-01
PURL
http://purl.flvc.org/fau/228753
Subject Headings
Behavior--drug effects., Psychopharmacology--Animal models., Psychopharmacology--Research.
Format
Document (PDF)
Effects of daily cocaine on milk intake and motor activity in cannula-fed and bottle-fed rats
Title
Effects of daily cocaine on milk intake and motor activity in cannula-fed and bottle-fed rats.
Creator
Hertz, Jacqueline Moore, Florida Atlantic University, Wolgin, David L.
Abstract/Description
The purpose of this experiment was to determine if tolerance to cocaine-induced hypophagia involves learning to suppress stereotyped movements that interfere with feeding. Milk intake and motor activity were measured in rats fed via bottles or intraoral cannulas. On dose-response 1, the bottle group was more hypophagic than the cannula group at the 8, 16, and 32 mg/kg doses. After 60d of chronic cocaine (16 mg/kg), only the bottle-fed group showed tolerance, indicated by a shift to the right...
Show moreThe purpose of this experiment was to determine if tolerance to cocaine-induced hypophagia involves learning to suppress stereotyped movements that interfere with feeding. Milk intake and motor activity were measured in rats fed via bottles or intraoral cannulas. On dose-response 1, the bottle group was more hypophagic than the cannula group at the 8, 16, and 32 mg/kg doses. After 60d of chronic cocaine (16 mg/kg), only the bottle-fed group showed tolerance, indicated by a shift to the right on dose-response 2. Tolerance was accompanied by a decrease in activity, while activity in the cannula-fed groups given 16 or 32 mg/kg showed sensitization. These results suggest that moderate doses of cocaine interfere with feeding primarily by producing incompatible behaviors. Tolerance involves learning to inhibit these behaviors in order to feed.
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Date Issued
1997
PURL
http://purl.flvc.org/fcla/dt/15464
Subject Headings
Rats as laboratory animals, Conditioned response, Drug tolerance
Format
Document (PDF)