Current Search: Guzman, Esther A. (x)
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- Title
- Early effects of Lasonolide A on pancreatic cancer cells.
- Creator
- Isbrucker, Richard A., Guzman, Esther A., Pitts, Tara P., Wright, Amy E.
- Date Issued
- 2000
- PURL
- http://purl.flvc.org/fau/fd/FA00007053
- Subject Headings
- Macrolides, Sponges, Marine natural products, Pancreatic Neoplasms, Pancreas--Cancer
- Format
- Document (PDF)
- Title
- Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
- Creator
- Paterson, Ian, Naylor, G. J., Fujita, T., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/fau/fd/FA00007065
- Subject Headings
- Antineoplastic agents, Paclitaxel, Polyketides, Microtubules, Tubulin Modulators, Marine natural products
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol.
- Creator
- Paterson, Ian, Naylor, G. J., Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00007463
- Subject Headings
- Macrolides, Antimitotic Agents, Natural products, Tubulin
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of novel C2–C6 region analogues of dictyostatin.
- Creator
- Paterson, Ian, Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2009-03-15
- PURL
- http://purl.flvc.org/FCLA/DT/1745595
- Subject Headings
- Bioorganic chemistry, Cancer--Research
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.
- Creator
- Paterson, Ian, Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2008-12-01
- PURL
- http://purl.flvc.org/FCLA/DT/1591053
- Subject Headings
- Bioorganic chemistry, Cancer--Research
- Format
- Document (PDF)
- Title
- A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
- Creator
- Guzman, Esther A., Johnson, J. D., Linley, P. A., Wright, Amy E., Gunasekera, Sarath P.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/FCLA/DT/3318907
- Subject Headings
- Pancreas--Cancer, Apoptosis, Sponges--Research, Marine natural products, Drug Discovery
- Format
- Document (PDF)
- Title
- The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells.
- Creator
- Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
- Abstract/Description
-
Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on...
Show moreManzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on yeast vacuoles, where manzamine A produced a phenotype very similar to that of the established v-ATPase inhibitor bafilomycin A1. In pancreatic cancer cells, 10 μM manzamine A affected vacuolar ATPase activity and significantly increased the level of autophagosome marker LC3-II and p62/SQSTM1 as observed by western blot analysis. Treatment with manzamine A in combination with bafilomycin A1 (inhibitor of autophagosome-lysosome fusion) did not change the levels of LC3-II when compared to cells treated with bafilomycin A1 alone, suggesting that manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. As autophagy is essential for pancreatic tumor growth, blocking this pathway with manzamine A suggests a promising strategy for the treatment of pancreatic cancer.
Show less - Date Issued
- 2013-09-17
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000075
- Format
- Citation
- Title
- Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516.
- Creator
- Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
- Abstract/Description
-
We found two errors in our previous published paper [1]. Figure 4A has a mistake in the units in the labels, where it shows mM instead of micromolar (μM). A correctly labeled Figure 4A ensues. In Figures 2 and 4, the size bar scale is micrometers (μm). We apologize for the inconvenience caused to our readers.
- Date Issued
- 2014-04-21
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000076
- Format
- Citation
- Title
- Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
- Creator
- Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
- Date Issued
- 2013-04-02
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000178
- Format
- Citation
- Title
- Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines.
- Creator
- Guzman, Esther A., Johnson, J. D., Carrier, M. K., Meyer, C. I., Pitts, Tara P., Gunasekera, Sarath P., Wright, Amy E.
- Date Issued
- 2009
- PURL
- http://purl.flvc.org/fau/fd/FA00007114
- Subject Headings
- Pancreas--Cancer, Marine natural products, Drug Discovery, Sponges--Caribbean Sea, Mechanism of action (Biochemistry)
- Format
- Document (PDF)
- Title
- NOAA CIOERT Report: Survey of the Deep-Sea Coral and Sponge Ecosystem of Pourtalés. NOAA Ship Nancy Foster Florida Shelf-Edge Exploration II (FLoSEE) Cruise Leg 2-September 23-30, 2011. (NOAA Project Number: NF-11-09-CIOERT).
- Creator
- Reed, John K., Farrington, Stephanie, David, Andrew, Messing, Charles G., Guzman, Esther A., Pomponi, Shirley A.
- Date Issued
- 2012
- PURL
- http://purl.flvc.org/FCLA/DT/3340531
- Subject Headings
- Corals Ecology, Sponges Ecology, Cooperative Institute for Ocean Exploration, Research, and Technology (U.S.), United States. National Oceanic and Atmospheric Administration, Oceanography--Research, Florida, Straits of
- Format
- Document (PDF)
- Title
- Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
- Creator
- Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
- Date Issued
- 2007
- PURL
- http://purl.flvc.org/FCLA/DT/3333011
- Subject Headings
- Sponges, Macrolides, Marine natural products
- Format
- Document (PDF)
- Title
- Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
- Creator
- Paterson, Ian, Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzman, Esther A., Isbrucker, Richard A., Pitts, Tara P., Linley, P. A., Divlianska, D. B., Reed, John K., Wright, Amy E.
- Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00007465
- Subject Headings
- Antimitotic Agents, Macrolides, Sponges, Molecular structure, Nuclear Magnetic Resonance, Biomolecular, Cell lines
- Format
- Document (PDF)
- Title
- An Assessment of Potential Threats to Human Health from Algae Blooms in the Indian River Lagoon (USA) 2018–2021: Unique Patterns of Cytotoxicity Associated with Toxins.
- Creator
- Esther Guzman, Tara A. Peterson, Priscilla L. Winder, Kirstie T. Francis, Malcolm McFarland, Jill C. Roberts, Jennifer Sandle, Amy E. Wright
- Abstract/Description
-
The Indian River Lagoon (IRL), a 156-mile-long estuary located on the eastern coast of Florida, experiences phytoplankton bloom events due to increased seasonal temperatures coupled with anthropogenic impacts. This study aimed to gather data on the toxicity to human cells and to identify secondary metabolites found in water samples collected in the IRL. Water samples from 20 sites of the IRL were collected during the wet and dry seasons over a three-year period. A panel of cell lines was used...
Show moreThe Indian River Lagoon (IRL), a 156-mile-long estuary located on the eastern coast of Florida, experiences phytoplankton bloom events due to increased seasonal temperatures coupled with anthropogenic impacts. This study aimed to gather data on the toxicity to human cells and to identify secondary metabolites found in water samples collected in the IRL. Water samples from 20 sites of the IRL were collected during the wet and dry seasons over a three-year period. A panel of cell lines was used to test cytotoxicity. Hemagglutination, hemolysis, and inhibition of protein phosphatase 2A (PP2A) were also measured. Cytotoxic blooms were seen both in the south (Microcystis) and the north (Pyrodinium) of the IRL. Each toxin induced a consistent pattern of cytotoxicity in the panel of human cell lines assayed. During blooms, cytotoxicity due to a single type of toxin is obvious from this pattern. In the absence of blooms, the cytotoxicity seen reflected either a mixture of toxins or it was caused by an unidentified toxin. These observations suggest that other toxins with the potential to be harmful to human health may be present in the IRL. Moreover, the presence of toxins in the IRL is not always associated with blooms of known toxin-producing organisms.
Show less - Date Issued
- 2023
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000517
- Format
- Document (PDF)
- Title
- Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix.
- Creator
- Wright, Amy E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, Susan H., Guzman, Esther A., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
- Date Issued
- 2009
- PURL
- http://purl.flvc.org/FCLA/DT/3319109
- Subject Headings
- Sponges --Research, Marine metabolites, Marine natural products, Hexactinellida
- Format
- Document (PDF)