Current Search: Guthrie, Kathleen M. (x)
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- Title
- Adult neural stem cell proliferation is not altered in trans-genic mice overexpressing BDNF or mutant HTT in forebrain.
- Creator
- Bahga, Dalbir, Guthrie, Kathleen M.
- Date Issued
- 2012-04-06
- PURL
- http://purl.flvc.org/fcla/dt/3348622
- Subject Headings
- Neural stem cells, Subventricular zone, Brain-derived neuro-trophic factor, Stem cell proliferation
- Format
- Document (PDF)
- Title
- Adult olfactory neuron turnover and the asscociation between fractalkine and microglia.
- Creator
- Mello, Rebecca Femandes, Guthrie, Kathleen M.
- Date Issued
- 2013-04-05
- PURL
- http://purl.flvc.org/fcla/dt/3361154
- Subject Headings
- Olfactory Receptor Neurons, Olfactory Bulb--physiology, Cell death, Microglia, Chemokines
- Format
- Document (PDF)
- Title
- Expression of c-fos mRNA in the basal ganglia associated with contingent tolerance to amphetamine-induced hypophagia.
- Creator
- Wolgin, David L., Bachand, Kimberlee D., Guthrie, Kathleen M.
- Date Issued
- 2009-03-17
- PURL
- http://purl.flvc.org/fau/228630
- Subject Headings
- Psychopharmacology--Research., Pharmacology--Research--Methodology., Neurosciences--Research--Methodology., Animal experimentation.
- Format
- Document (PDF)
- Title
- Effects of target neuron loss on olfactory sensory neurons in adult mice.
- Creator
- Ardiles, Yona., Florida Atlantic University, Guthrie, Kathleen M.
- Abstract/Description
-
Olfactory sensory neurons (OSN) expressing the same odor receptor (OR) project their axons to topographically fixed glomeruli in the olfactory bulb (OB). This topographic map results from axon guidance mechanisms determined by ORs, glia and molecular guidance cues. The present study examined the organization of mature OSNs expressing the P2 OR in adult mice after ablation of bulb neurons with N-methyl-D-aspartate (NMDA). Rapid neuronal degeneration was followed by progressive laminar...
Show moreOlfactory sensory neurons (OSN) expressing the same odor receptor (OR) project their axons to topographically fixed glomeruli in the olfactory bulb (OB). This topographic map results from axon guidance mechanisms determined by ORs, glia and molecular guidance cues. The present study examined the organization of mature OSNs expressing the P2 OR in adult mice after ablation of bulb neurons with N-methyl-D-aspartate (NMDA). Rapid neuronal degeneration was followed by progressive laminar disorganization of the OB and glomerular shrinkage. P2 axon targeting and convergence was maintained within degenerating glomeruli for up to 2 weeks. After that time, fewer P2 axons were observed in the lesioned OB with fewer P2 neurons in the olfactory epithelium (OE). By 3 weeks, the mature OSN population was reduced and the immature population was increased. These results suggest that bulbar synaptic contacts do not maintain sensory axon convergence in the adult, but regulate neuronal survival in the OE.
Show less - Date Issued
- 2004
- PURL
- http://purl.flvc.org/fcla/dt/13166
- Subject Headings
- Sensory neurons--Testing, Senses and sensation, Neurotransmitter receptors, Mice as laboratory animals, Smell--Research--Methodology
- Format
- Document (PDF)
- Title
- Effects of Target Neuron Loss on Olfactory Receptor Neurons in the Adult Rat.
- Creator
- Sultan, Krista K., Guthrie, Kathleen M., Florida Atlantic University
- Abstract/Description
-
Unlike most neurons in the adult nervous system, olfactory receptor neurons (ORN), found in the olfactory epithelium (OE), continually turnover in the adult rat. These neurons project their axons to the olfactory bulb which is their central target. The present study eliminated target neurons in the bulb using N-methyl-D-aspartate (NMDA) to examine the effects of target loss on ORN survival and maturation. We compared the effects of the NMDA lesion to bulbectomy, a permanent surgical removal...
Show moreUnlike most neurons in the adult nervous system, olfactory receptor neurons (ORN), found in the olfactory epithelium (OE), continually turnover in the adult rat. These neurons project their axons to the olfactory bulb which is their central target. The present study eliminated target neurons in the bulb using N-methyl-D-aspartate (NMDA) to examine the effects of target loss on ORN survival and maturation. We compared the effects of the NMDA lesion to bulbectomy, a permanent surgical removal of the bulb, which simultaneously causes damage to ORN axons. We found that unlike bulbectomy, large numbers of dying OE cells were not observed at any time after the lesion. The number of immature neurons increased relative to the control side, and the number of mature neurons also slightly increased with time following NMDA lesion. Survival of ORNs does not seem to be significantly altered in the absence of its target.
Show less - Date Issued
- 2007
- PURL
- http://purl.flvc.org/fau/fd/FA00000838
- Subject Headings
- Rats--Physiology, Neurophysiology, Apoptosis, Regeneration (Biology)
- Format
- Document (PDF)
- Title
- Anterograde trophic signaling in the olfactory system: neurotrophin-3 expressed by olfactory sensory neurons is transported to target bulb neurons in adult mice.
- Creator
- Liu, Huan, Guthrie, Kathleen M., Charles E. Schmidt College of Science, Department of Biological Sciences
- Abstract/Description
-
The adult rodent olfactory system provides an excellent model for the study of the developing nervous system due to its constant integration of new neurons and establishment of new synapses throughout life. This allows for adaptive structural responses to sensory experience that continuously shape functional circuits to fit the behavioral needs of the animal. The cellular mechanisms underlying the anatomical plasticity of the adult olfactory system are not well understood, but neurotrophins,...
Show moreThe adult rodent olfactory system provides an excellent model for the study of the developing nervous system due to its constant integration of new neurons and establishment of new synapses throughout life. This allows for adaptive structural responses to sensory experience that continuously shape functional circuits to fit the behavioral needs of the animal. The cellular mechanisms underlying the anatomical plasticity of the adult olfactory system are not well understood, but neurotrophins, long recognized as crucial to the early development of neuronal circuits, are attractive candidate molecules in this capacity. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), two members of the neurotrophin family, have received attention in terms of their anatomical distribution and physiological functions in the olfactory system.
Show less - Date Issued
- 2012
- PURL
- http://purl.flvc.org/fau/fd/FA00004255
- Format
- Document (PDF)
- Title
- Over-Expression of BDNF Does Not Rescue Sensory Deprivation-Induced Death of Adult-Born Olfactory Granule Cells.
- Creator
- Berger, Rachel A., Guthrie, Kathleen M., Florida Atlantic University, Charles E. Schmidt College of Medicine, Department of Biomedical Science
- Abstract/Description
-
It is of interest to understand how new neurons incorporate themselves into the existing circuitry of certain neuronal populations. One such population of neurons is that which are born in the subventricular zone (SVZ) and migrate to the olfactory bulb where they differentiate into granule cells. Another area of interest is the role of brain-derived neurotrophic factor (BDNF) on the survival and overall health of these neurons. This study aimed to test whether or not BDNF is a survival factor...
Show moreIt is of interest to understand how new neurons incorporate themselves into the existing circuitry of certain neuronal populations. One such population of neurons is that which are born in the subventricular zone (SVZ) and migrate to the olfactory bulb where they differentiate into granule cells. Another area of interest is the role of brain-derived neurotrophic factor (BDNF) on the survival and overall health of these neurons. This study aimed to test whether or not BDNF is a survival factor for adult-born granule cells. Here were utilized a transgenic mouse model over-expressing BDNF under the α- calcium/calmodulin-dependent protein kinase II (CAMKIIα) promoter, and tested its effect on olfactory granule cells under sensory deprived conditions. Results from this experiment indicated that there was no significant difference in cell death or cell survival when comparing transgenic and wild type animals. We concluded that BDNF is not a survival factor for adult-born granule cells.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FA00004722, http://purl.flvc.org/fau/fd/FA00004722
- Subject Headings
- Cellular control mechanisms, Mice as laboratory animals, Nervous system -- Diseases -- Gene therapy, Neural circuitry, Neuroplasticity, Neurotransmitter receptors, Sensory deprivation, Sensory neurons -- Testing
- Format
- Document (PDF)