Current Search: DiCicco, Rebecca (x)
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Title
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CELL-TYPE-SPECIFIC CONSOLIDATION OF LEARNED MOTOR MEMORIES IN THE NEOCORTEX.
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Creator
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DiCicco, Rebecca, Young, Erica, Harriet L. Wilkes Honors College, Florida Atlantic University
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Abstract/Description
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Motor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill...
Show moreMotor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill acquisition. This project aims to explore how the brain consolidates the acquired motor skill as a long-term memory. We hypothesize that following motor learning, CaMKII in PT, but not IT, cells activates the expression of immediate early genes (IEGs) arc and cfos, which may play a critical role in the storage of motor memories. Understanding the cell-specific roles in the ALM could provide insights into motor memory neural circuitry and diseases.
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Date Issued
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2024
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PURL
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http://purl.flvc.org/fau/fd/FAUHT00296
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Format
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Document (PDF)