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Onuphis Simoni, a new species of polychaete (Polychaeta: Onuphidae) from South Florida
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
Introduction