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From Treatment to Trauma: First-Line Cancer Treatment and Cancer-Related Post-Traumatic Stress Disorder
Title
From Treatment to Trauma: First-Line Cancer Treatment and Cancer-Related Post-Traumatic Stress Disorder.
Creator
Ly, An, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University, Earles, Julie
Abstract/Description
The epidemiology of cancer-related PTSD is well-documented, but the effect of first-line cancer treatments on the prevalence and severity of PTSD has yet to be consolidated. Unlike many other traumatic events preceding the onset of post-traumatic stress disorder (PTSD), the cancer experience has ongoing stages of diagnosis, treatment, and survivorship that each present their own stressors. Due to the multifaceted nature of cancer-related trauma, it is important to understand how each...
Show moreThe epidemiology of cancer-related PTSD is well-documented, but the effect of first-line cancer treatments on the prevalence and severity of PTSD has yet to be consolidated. Unlike many other traumatic events preceding the onset of post-traumatic stress disorder (PTSD), the cancer experience has ongoing stages of diagnosis, treatment, and survivorship that each present their own stressors. Due to the multifaceted nature of cancer-related trauma, it is important to understand how each component of the experience plays a role in the onset of mental illness. Thus, I review the existing literature to elucidate how the biochemical changes induced by chemotherapy, radiation, and surgery influence the onset and prevalence of cancer-related PTSD. In being informed of the physiological processes underlying treatment and their implications for mental health, patients and clinicians alike can better predict the psychological changes that occur alongside cancer treatment.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00148
Format
Document (PDF)
THE HISTORY, CHEMISTRY, AND REGULATION OF COSMETICS
Title
THE HISTORY, CHEMISTRY, AND REGULATION OF COSMETICS.
Creator
Cook, Carly E., Chandrasekhar, Chitra, Florida Atlantic University, Harriet L. Wilkes Honors College
Abstract/Description
Cosmetics have played an integral part in beautifying humankind for tens of thousands of years. The practice of people enhancing their natural features dates back several millennia before written text to ancient Egyptian and other early civilizations. Throughout time, these augmentation methods have been studied and perfected to create what is now a multibillion-dollar industry. The earliest forms of cosmetics derived from locally available natural resources but over time transformed to...
Show moreCosmetics have played an integral part in beautifying humankind for tens of thousands of years. The practice of people enhancing their natural features dates back several millennia before written text to ancient Egyptian and other early civilizations. Throughout time, these augmentation methods have been studied and perfected to create what is now a multibillion-dollar industry. The earliest forms of cosmetics derived from locally available natural resources but over time transformed to incorporate synthetic and potentially harmful substances including lead, formaldehyde, and benzophenone. The objective of this thesis is to investigate the timeline of cosmetic use and to inquire into the compulsion to use cosmetics for embellishing the natural look, the introduction of artificial chemicals into cosmetics, the minimal protective legislative guidelines currently in place, and the necessary reforms required to ensure the safety of the consumer.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00003701
Format
Document (PDF)
Preventative Treatments of Diabetes and Non-Alcoholic Fatty Liver Disease
Title
Preventative Treatments of Diabetes and Non-Alcoholic Fatty Liver Disease.
Creator
Bansal, Nikita, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Diabetes mellitus type 2 is a long-term metabolic disease that is currently ranked as the seventh leading cause of mortality in the United States and ninth leading cause worldwide. Recognized as a global health problem, diabetes mellitus is a chronic condition that involves multiple organ systems and can often lead to irreversible damage. Long term complications include neuropathy, retinopathy, nephropathy, cardiovascular disease, and hepatopathy. Diabetes is associated with a wide spectrum...
Show moreDiabetes mellitus type 2 is a long-term metabolic disease that is currently ranked as the seventh leading cause of mortality in the United States and ninth leading cause worldwide. Recognized as a global health problem, diabetes mellitus is a chronic condition that involves multiple organ systems and can often lead to irreversible damage. Long term complications include neuropathy, retinopathy, nephropathy, cardiovascular disease, and hepatopathy. Diabetes is associated with a wide spectrum of liver diseases; the most common is non-alcoholic fatty liver disease, which can lead to liver failure. Sedentary lifestyles in industrialized countries are often seen as the inadvertent cause of increasing obesity and diabetes despite the thoroughly researched treatment plans available. In this study, I will examine the role of lifestyle and dietary modifications (including plant-based diet) in controlling diabetes and diabetes related complications, specifically non-alcoholic fatty liver disease.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00135
Format
Document (PDF)
ANALYSIS OF MENTHOL EXTRACTED FROM MINT LEAVES USING VCD AND COMPUTATION GENERATED SPECTRA
Title
ANALYSIS OF MENTHOL EXTRACTED FROM MINT LEAVES USING VCD AND COMPUTATION GENERATED SPECTRA.
Creator
Xu, Ethan, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Recently, the terpene class of molecules have been under much interest due to their potential medicinal properties. Terpenes such as cannabidiol and tetrahydrocannabinol have been studied for their psychological effects, while others like myrcene are of interest due to their antifungal and antibacterial properties. However, some of these terpenes possess different properties dependent on their stereochemistry, potentially with one enantiomer having the desired the effect and the other having...
Show moreRecently, the terpene class of molecules have been under much interest due to their potential medicinal properties. Terpenes such as cannabidiol and tetrahydrocannabinol have been studied for their psychological effects, while others like myrcene are of interest due to their antifungal and antibacterial properties. However, some of these terpenes possess different properties dependent on their stereochemistry, potentially with one enantiomer having the desired the effect and the other having a reduced or even harmful effect in some cases. Despite the importance of stereochemistry in medicine, techniques that are sensitive to it are still uncommon, but one technique in the form of VCD/IR spectroscopy has been under interest due to its ability to effectively analyze small molecules with limited flexibility, such as many terpenes. This thesis will cover the use of VCD/IR spectroscopy in the analysis of menthol from Mentha piperita, specifically the stereochemistry based on a known pure sample, and through calculated spectra.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FAUHT00225
Format
Document (PDF)
The Genetics of Atherosclerosis and Coronary Artery Disease
Title
The Genetics of Atherosclerosis and Coronary Artery Disease.
Creator
Stridinger, Craig, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Atherosclerosis is a disease characterized by plaque lesion formation in arteries resulting in the narrowing and hardening of the vessel. This process causes a restriction in blood flow and can lead to further complications including the development of coronary artery disease, heart disease, and myocardial infarction. For many years, atherosclerosis was thought to be a disease resulting from hypercholesterolemia, but it is now known that the inflammatory process is a greater contributor to...
Show moreAtherosclerosis is a disease characterized by plaque lesion formation in arteries resulting in the narrowing and hardening of the vessel. This process causes a restriction in blood flow and can lead to further complications including the development of coronary artery disease, heart disease, and myocardial infarction. For many years, atherosclerosis was thought to be a disease resulting from hypercholesterolemia, but it is now known that the inflammatory process is a greater contributor to the pathogenesis of the disease. Numerous genes have been identified that play a role in the development of atherosclerosis, and novel therapeutics are being developed to treat it, but prevention is preferable to treatment. The goal of this thesis is to discuss the atherosclerotic inflammatory process, genetic factors of atherosclerosis, current therapeutic strategies, and how the use of genetic profiling should be used to prevent the development of atherosclerosis.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FAUHT00221
Format
Document (PDF)
The Effect of Sulindac on Senescence in Retinal Pigmented Epithelial Cells
Title
The Effect of Sulindac on Senescence in Retinal Pigmented Epithelial Cells.
Creator
Manoharan, Samuel, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Age-related macular degeneration is the leading cause of blindness in industrialized countries. Cellular senescence was shown to be involved int he pathogenesis of AMD. We have shown that sulindac, a non-steroidal anti-inflammatory drug, protects normal cells such as retinal cells against oxidative damage through preconditioning mechanism. To test this, we established an in vitro model for senescence in RPE cells by a treatment of hydrogen peroxide (oxidative stressor) for 12 hours followed...
Show moreAge-related macular degeneration is the leading cause of blindness in industrialized countries. Cellular senescence was shown to be involved int he pathogenesis of AMD. We have shown that sulindac, a non-steroidal anti-inflammatory drug, protects normal cells such as retinal cells against oxidative damage through preconditioning mechanism. To test this, we established an in vitro model for senescence in RPE cells by a treatment of hydrogen peroxide (oxidative stressor) for 12 hours followed by incubation for four days. We assayed for senescence by Beta-galactosidase assay to stain senescent cells. Effect of sulindac was tested by pre-treating cells with sulindac at different concentrations for 24 h prior to Tetra Butyl Hydrogen Peroxide treatment. The data shows that Sulindac reduced number of senescent cells in the samples treated compared to the control groups. These findings indicate oxidative damage induces cellular senescence, and sulindac lowers the amount of senescence by protecting from oxidative damage.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FAUHT00207
Format
Document (PDF)
Screening for novel small molecule binders of RNA repeat expansions
Title
Screening for novel small molecule binders of RNA repeat expansions.
Creator
De Oliveira, Isabela Caiado, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
RNA performs a number of vital roles in the human cell, such as turning genetic information into proteins in the human body and gene regulation via numerous mechanisms. Therefore, its malfunction may lead to severe diseases such as Huntington’s disease or Myotonic Dystrophy type 1. Huntington’s disease is a rare neurodegenerative disease most likely inherited, and it is caused by the trinucleotide repeat expansion r(CAG)exp in the huntingtin gene (HTT). Myotonic dystrophy type 1 is an...
Show moreRNA performs a number of vital roles in the human cell, such as turning genetic information into proteins in the human body and gene regulation via numerous mechanisms. Therefore, its malfunction may lead to severe diseases such as Huntington’s disease or Myotonic Dystrophy type 1. Huntington’s disease is a rare neurodegenerative disease most likely inherited, and it is caused by the trinucleotide repeat expansion r(CAG)exp in the huntingtin gene (HTT). Myotonic dystrophy type 1 is an untreatable neuromuscular disorder caused by the trinucleotide repeat expansion r(CUG)exp. The biology of healthy or disease-infected cells is usually determined by RNA structures, which are desirable targets for chemical probe and lead compounds. Targeting these RNAs with small molecules provides opportunities to affect their function and therapeutically change many pathologic cellular processes. The purpose of this study is to use a fragment-based approach to find small molecules that bind these two trinucleotides repeat expansions by phenotypic screening that involves a luciferase reporter assay for r(CAG)exp, and a target-based approach involving NMR spectroscopy for r(CUG)exp.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FAUHT00193
Format
Document (PDF)
ARE ELECTRIC CARS REALLY MORE CARBON EFFICIENT THAN GASOLINE CARS?
Title
ARE ELECTRIC CARS REALLY MORE CARBON EFFICIENT THAN GASOLINE CARS?.
Creator
Fitzgerald, Aethena, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Ever since the invention of the wheel, humans have been trying to find faster and more efficient modes of transportation. The evolution from the first horse-drawn carriages to the currently popular electric vehicles marks a big improvement in speed and reliability. Today, modern society relies heavily on cars, the most popular mode of transportation. There are two main classes of automobiles: fossil fuel (gasoline and diesel) and electric. Fossil fuel cars are known for their carbon...
Show moreEver since the invention of the wheel, humans have been trying to find faster and more efficient modes of transportation. The evolution from the first horse-drawn carriages to the currently popular electric vehicles marks a big improvement in speed and reliability. Today, modern society relies heavily on cars, the most popular mode of transportation. There are two main classes of automobiles: fossil fuel (gasoline and diesel) and electric. Fossil fuel cars are known for their carbon inefficiency, which leads to large amounts of greenhouse gases being emitted into the Earth’s atmosphere. In recent years, electric vehicles have gained limited popularity and are reported to produce fewer carbon emissions. However, the big question is whether or not they are actually more carbon efficient, especially when one considers the production both the interior and exteriors car components and the specialized batteries required to power the vehicles.
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Date Issued
2024
PURL
http://purl.flvc.org/fau/fd/FAUHT00299
Format
Document (PDF)
Isolating the Manganese Superoxide Dismutase Gene (SOD2) from T. scripta""
Title
Isolating the Manganese Superoxide Dismutase Gene (SOD2) from T. scripta"".
Creator
Sanchez, Jairo, Kirchman, Paul A., Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Reactive oxygen species (ROS) are molecular oxygen-derived molecules that are exceedingly reactive, often generated as free radical bi-products of mitochondrial respiration, which cause oxidative stress that leads to aging. To avoid the generation of ROS, aerobic organisms have antioxidant defense mechanisms that use enzymes such as Superoxide Dismutase (SOD) to convert the superoxide radicals into hydrogen peroxide and oxygen. Manganesecontaining SOD (Mn-SOD), a product of the SOD2 gene is...
Show moreReactive oxygen species (ROS) are molecular oxygen-derived molecules that are exceedingly reactive, often generated as free radical bi-products of mitochondrial respiration, which cause oxidative stress that leads to aging. To avoid the generation of ROS, aerobic organisms have antioxidant defense mechanisms that use enzymes such as Superoxide Dismutase (SOD) to convert the superoxide radicals into hydrogen peroxide and oxygen. Manganesecontaining SOD (Mn-SOD), a product of the SOD2 gene is found in all eukaryotic organisms in the mitochondrial matrix, including T. scripta (red-eared slider turtle). Extraordinarily, T. scripta can live without oxygen for long periods of time without experiencing adverse effects when oxygen is again available. The purpose of our experiment is to clone the T. scripta SOD2 gene, and test its activity. A partial fragment of the gene has been isolated by screening the cDNA library, and we are currently working on finding the remaining sequence.
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Date Issued
2011
PURL
http://purl.flvc.org/fau/fd/FA00003605
Format
Document (PDF)
The Role of IL-17 in T-Cell Development
Title
The Role of IL-17 in T-Cell Development.
Creator
Gopaldas, Manesh, Kirchman, Paul A., Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
T-lymphocytes develop from bone marrow derived hematopoietic stem cells (HSCs) and mature in the thymus, where they participate in reciprocal signaling with thymic stromal cells. The thymic developmental stages are well characterized, but only a few intrathymic signals that influence the development of T-lymphocytes have been identified. Previous microarray experiments revealed interleukin-17A (IL-17A) and its receptor (IL-17RA) as a possible stromal-lymphoid signal. In this study, an IL-17RA...
Show moreT-lymphocytes develop from bone marrow derived hematopoietic stem cells (HSCs) and mature in the thymus, where they participate in reciprocal signaling with thymic stromal cells. The thymic developmental stages are well characterized, but only a few intrathymic signals that influence the development of T-lymphocytes have been identified. Previous microarray experiments revealed interleukin-17A (IL-17A) and its receptor (IL-17RA) as a possible stromal-lymphoid signal. In this study, an IL-17RA-/- knockout was used to determine whether the IL-17RA gene has a role in T-lymphocyte maturation. We made competitive bone marrow chimeras and analyzed the percentage of donor wildtype and mutant HSCs present in the bone marrow, and compared it to the percentage of a particular blood cell type that developed from these donor HSCs. We found that IL-17RA influences the maturation of T-lymphocytes, but does not affect the development of other immune cells such as B-lymphocytes, macrophages, and granulocytes.
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Date Issued
2011
PURL
http://purl.flvc.org/fau/fd/FA00003578
Format
Document (PDF)