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Replacement of sex steroids prevent lymphocytic infiltration of the lacrimal glands in Sjögren's Syndrome (SS)
Title
Replacement of sex steroids prevent lymphocytic infiltration of the lacrimal glands in Sjögren's Syndrome (SS).
Creator
Mostafa, Safinaz, Azzarolo , Ana Maria, Graduate College
Date Issued
2011-04-08
PURL
http://purl.flvc.org/fcla/dt/3164642
Subject Headings
Sjogren's syndrome, Hormones, Sex, Blood --Pathophysiology
Format
Document (PDF)
Regulation of tear lipocalin and MMPs by sex hormones in rabbit lacrimal gland: Implication in dry eye disease
Title
Regulation of tear lipocalin and MMPs by sex hormones in rabbit lacrimal gland: Implication in dry eye disease.
Creator
Vellala, Kavyasri, Florida Atlantic University, Azzarolo, Ana Maria
Abstract/Description
Tear lipocalin (TL) (~18kDa), is one of the major proteins in rabbit lacrimal fluid. The aim was to study the regulation of tear lipocalin by sex hormones. Results indicate that sexually mature female rabbits have a significantly higher expression of TL than sexually mature male rabbits. TL expression was higher in sexually mature rabbits than the juvenile rabbits. No significant difference was seen among the juvenile female and male rabbits. Rabbits were also sham operated, ovariectomized...
Show moreTear lipocalin (TL) (~18kDa), is one of the major proteins in rabbit lacrimal fluid. The aim was to study the regulation of tear lipocalin by sex hormones. Results indicate that sexually mature female rabbits have a significantly higher expression of TL than sexually mature male rabbits. TL expression was higher in sexually mature rabbits than the juvenile rabbits. No significant difference was seen among the juvenile female and male rabbits. Rabbits were also sham operated, ovariectomized and ovariectomized followed by either estrogen or androgen treatment. Androgen treated rabbits expressed significantly higher amounts of TL when compared to the other groups. This study also focused on sex hormone regulation of the gelatinases MMP-2 and MMP-9. All four treated groups expressed MMP-2, but the estrogen treated rabbit showed the highest expression; however, only the estrogen treated rabbit expressed MMP-9 and no expression was seen in the other three groups.
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Date Issued
2005
PURL
http://purl.flvc.org/fcla/dt/13306
Subject Headings
Lacrimal apparatus--Diseases, Dry eye syndromes, Tears--Physiology, Rabbits--Physiology, Rabbits as laboratory animals
Format
Document (PDF)