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Title: A systematic revision of the Central Atlantic Halichondrida (Demospongiae, Porifera). Part II. Patterns of distribution of secondary metabolites.
Creator: Pomponi, Shirley A., Wright, Amy E., Diaz, Maria Cristina, Van Soest, Rob W. M.
Date Issued: 1991
PURL: http://purl.flvc.org/FCLA/DT/3333131
Subject Headings: Halichondrida, Secondary metabolites, Demospongiae--Classification
Format: Document (PDF)

Title: The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells.
Creator: Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
Abstract/Description: Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on...
Show moreManzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on yeast vacuoles, where manzamine A produced a phenotype very similar to that of the established v-ATPase inhibitor bafilomycin A1. In pancreatic cancer cells, 10 μM manzamine A affected vacuolar ATPase activity and significantly increased the level of autophagosome marker LC3-II and p62/SQSTM1 as observed by western blot analysis. Treatment with manzamine A in combination with bafilomycin A1 (inhibitor of autophagosome-lysosome fusion) did not change the levels of LC3-II when compared to cells treated with bafilomycin A1 alone, suggesting that manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. As autophagy is essential for pancreatic tumor growth, blocking this pathway with manzamine A suggests a promising strategy for the treatment of pancreatic cancer.
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Date Issued: 2013-09-17
PURL: http://purl.flvc.org/fau/fd/FAUIR000075
Format: Citation

Title: Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516.
Creator: Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
Abstract/Description: We found two errors in our previous published paper [1]. Figure 4A has a mistake in the units in the labels, where it shows mM instead of micromolar (μM). A correctly labeled Figure 4A ensues. In Figures 2 and 4, the size bar scale is micrometers (μm). We apologize for the inconvenience caused to our readers.
Date Issued: 2014-04-21
PURL: http://purl.flvc.org/fau/fd/FAUIR000076
Format: Citation

Title: Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
Creator: Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
Date Issued: 2013-04-02
PURL: http://purl.flvc.org/fau/fd/FAUIR000178
Format: Citation

Title: Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity.
Creator: Gunasekera, Sarath P., Mickel, Stuart J., Daeffler, Robert, Niederer, Daniel, Wright, Amy E., Linley, P. A., Pitts, Tara P.
Date Issued: 2004
PURL: http://purl.flvc.org/FCLA/DT/3164107
Subject Headings: Microtubules, Cancer --Research, Biopharmaceutics, Molecular biology, Stereochemistry
Format: Document (PDF)

Title: Microxine, a New cdc2 Kinase Inhibitor from the Australian MarinE Sponge Microxina Species.
Creator: Killday, K. B., Yarwood, Donna, Sills, Matthew A., Murphy, Peter T., Hooper, J. N. A., Wright, Amy E.
Date Issued: 2001
PURL: http://purl.flvc.org/FCLA/DT/3164092
Subject Headings: Sponges, Chromatographic analysis, Spectrum analysis, Phosphoprotein Phosphatase --analysis, Nucleosides
Format: Document (PDF)

Title: Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines.
Creator: Guzman, Esther A., Johnson, J. D., Carrier, M. K., Meyer, C. I., Pitts, Tara P., Gunasekera, Sarath P., Wright, Amy E.
Date Issued: 2009
PURL: http://purl.flvc.org/fau/fd/FA00007114
Subject Headings: Pancreas--Cancer, Marine natural products, Drug Discovery, Sponges--Caribbean Sea, Mechanism of action (Biochemistry)
Format: Document (PDF)

Title: Metabolites from the Marine-Derived Fungus Chromocleista sp. Isolated from a Deep-Water Sediment Sample Collected in the Gulf of Mexico.
Creator: Park, Young Chul, Gunasekera, Sarath P., Lopez, Jose V., McCarthy, Peter J., Wright, Amy E.
Date Issued: 2006
PURL: http://purl.flvc.org/FCLA/DT/3164115
Subject Headings: Metabolites, Fungal metabolites, Marine fungi, X-ray crystallography, Marine sediments
Format: Document (PDF)

Title: Marine natural products.
Creator: Pomponi, Shirley A., Wright, Amy E., Reed, John K., McCarthy, Peter J.
Date Issued: 1999
PURL: http://purl.flvc.org/fau/fd/FA00007503
Subject Headings: Marine natural products
Format: Document (PDF)

Title: A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites.
Creator: Wright, Amy E., Pomponi, Shirley A., Cross, S. S., McCarthy, Peter J.
Date Issued: 1992
PURL: http://purl.flvc.org/FCLA/DT/3333002
Subject Headings: Sponges, Indole alkaloids, Marine natural products
Format: Document (PDF)

Title: Natural products from marine invertebrates: the Harbor Branch Oceanographic Institution experience.
Creator: Sennett, Susan H., McCarthy, Peter J., Wright, Amy E., Pomponi, Shirley A.
Date Issued: 2002
PURL: http://purl.flvc.org/FCLA/DT/2796027
Subject Headings: Marine invertebrates, Polyketides, Bioactive compounds, Probiotics
Format: Document (PDF)

Title: Duryne, a new cytotoxic agent from the marine sponge Cribrochalina dura.
Creator: Wright, Amy E., McConnell, O. J., Kohmoto, S., Lui, M. S., Thompson, W., Snader, K. M.
Date Issued: 1987
PURL: http://purl.flvc.org/FCLA/DT/3353798
Subject Headings: Cytotoxin, Sponges, Marine natural products, Polyacetylenes
Format: Document (PDF)

Title: In vitro production of marine-derived antitumor compounds.
Creator: Pomponi, Shirley A., Willoughby, Robin, Wright, Amy E., Pecorella, C., Sennett, Susan H., Lopez, Jose V., Samples, Gail A.
Date Issued: 1998
PURL: http://purl.flvc.org/fau/fd/FA00007238
Subject Headings: Antineoplastic agents, Bioactive compounds, Marine natural products, In vitro, Antitumor agents
Format: Document (PDF)

Title: Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva.
Creator: Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Garay, M., Sills, Matthew A.
Date Issued: 1995
PURL: http://purl.flvc.org/FCLA/DT/3319084
Subject Headings: Sponges --Research, Marine natural products, Receptors, Thrombin, Aplysillin A, Antagonists, Enzyme, Marine pharmacology
Format: Document (PDF)

Title: Characterization of an interleukin 6 cytokinefamily antagonist protein from a marine sponge, Callyspongia sp.
Creator: Peppard, J. V., Loo, P., Sills, Matthew A., Munster, D., Pomponi, Shirley A., Wright, Amy E.
Date Issued: 1996
PURL: http://purl.flvc.org/fau/fd/FA00007266
Subject Headings: Sponges, Interleukin-6, Cytokines--antagonists & inhibitors
Format: Document (PDF)

Title: The discovery and characterization of an interleukin 6 cytokine familyantagonist protein from a marine sponge, Callyspongia sp.
Creator: Peppard, J. V., Loo, P., Sills, Matthew A., Wennogle, L., Wright, Amy E., Pomponi, Shirley A., Cueto, M.
Date Issued: 2001
PURL: http://purl.flvc.org/fau/fd/FA00007313
Subject Headings: Sponges, Interleukin-6, Cytokines--antagonists & inhibitors, Proteins--chemistry
Format: Document (PDF)

Title: Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.
Creator: Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Yarwood, Donna, Sills, Matthew A.
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3331880
Subject Headings: Sponges, Cyclic peptides, Peptides--Structure, Spectroscopic techniques
Format: Document (PDF)

Title: Deep-water sinkholes and bioherms of south Florida and the Pourtalés Terrace-habitat and fauna.
Creator: Reed, John K., Pomponi, Shirley A., Weaver, Doug C., Paull, Charles K., Wright, Amy E.
Date Issued: 2005
PURL: http://purl.flvc.org/FCLA/DT/3172087
Subject Headings: Sinkholes --Florida, Bioherms, Benthic animals, Groundfishes, Manned undersea research stations
Format: Document (PDF)

Title: Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
Creator: Gunasekera, Sarath P., McCarthy, Peter J., Longley, Ross E., Pomponi, Shirley A., Wright, Amy E., Lobkovsky, E., Clardy, J.
Date Issued: 1999
PURL: http://purl.flvc.org/FCLA/DT/3319100
Subject Headings: Sponges --Research, Marine natural products, discorhabdin P, Enzyme inhibitors
Format: Document (PDF)

Title: Discovery and investigation of survivin-targeting marine natural products from Ellisella paraplexauroides and Eudistoma olivaceum.
Creator: Francis, Kirstie Tandberg, Wright, Amy E., Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
Abstract/Description: In 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target...
Show moreIn 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target for new drug therapies. At only 16.5 kDa, it consists of a single Baculovirus IAP Repeat (BIR) domain and an α-helical coiled coil. Survivin plays a multitude of roles in the growth and survival of cancer cells—which can be attributed to the variable cellular localizations and posttranslational modifications of the protein—including inhibition of apoptosis, mitosis and cell cycle progression, DNA damage repair, drug resistance, metastasis, angiogenesis, and cell senescence, among others. A drug that is able to target surviving transcription or posttranslational modification or disrupt one of these critical pathways may serve as an attractive new cancer therapy. Despite decades of research on surviving and its intracellular functions, researchers have yet to find an FDA approved drug. Using a high throughput approach, Harbor Branch Oceanographic Institute’s chemical library of marine natural products was screened by the Guzmán lab to identify compounds capable of downregulating survivin expression in A549 non-small cell lung carcinoma and DLD-1 colorectal adenocarcinoma cell lines. From the screening assay, pure compounds were identified which reduce levels of survivin protein in cancer cells. Chapter 2 describes the isolation and structure elucidation of five polyhydroxylated sterol analogs from Ellisella paraplexauroides, four of them novel. Chapter 3 describes the isolation and structure elucidation of two compounds from Eudistoma olivaceum, eudistomin H and I. Chapter 4 describes the secondary biological testing employed to determine if the reduction of survivin expression was driven by reducing de novo production or increasing the degradation of existing protein by evaluating differential gene expression of survivin mRNA using reverse transcriptase quantitative polymerase chain reaction and measuring degradation rates of survivin protein, respectively.
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Date Issued: 2021
PURL: http://purl.flvc.org/fau/fd/FA00013828
Subject Headings: Survivin, Marine natural products, Antineoplastic agents--Development
Format: Document (PDF)

HBOI Faculty Contributions (84)	+ -
HBOI Technical Reports (3)	+ -
FAU Theses and Dissertations (1)	+ -

Sponges (35)	+ -
Marine natural products (32)	+ -
Antineoplastic agents (11)	+ -
Macrolides (7)	+ -
Marine metabolites (7)	+ -

Bioactive compounds (6)	+ -
Polyketides (6)	+ -
Sponges --Research (6)	+ -
Cytotoxin (5)	+ -
Sesquiterpenes (5)	+ -
Ascidians (4)	+ -
Chemical structure (4)	+ -
Microtubules (4)	+ -
Stereochemistry (4)	+ -
Alkaloids (3)	+ -
Antifungal agents (3)	+ -
Antimitotic Agents (3)	+ -
Antimitotic agents (3)	+ -
Biodiversity--Research (3)	+ -
Biomedical research (3)	+ -
Candida albicans (3)	+ -
Demospongiae (3)	+ -
Gorgonacea (3)	+ -
Indole alkaloids (3)	+ -
Pancreas--Cancer (3)	+ -
Spectrum analysis (3)	+ -
Sponges--Research (3)	+ -
Tubulin Modulators (3)	+ -
Aspergillus fumigatus (2)	+ -
Bioorganic chemistry (2)	+ -

article (84)	+ -
technical report (3)	+ -
Electronic Thesis or Dissertation (1)	+ -

Wright, Amy E. (87)	+ -
Pomponi, Shirley A. (42)	+ -
McCarthy, Peter J. (21)	+ -
Reed, John K. (16)	+ -
Gunasekera, Sarath P. (13)	+ -

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