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New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae
Title
New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae.
Creator
Chen, Ying, McCarthy, Peter J., Harmody, Dedra K., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/3164099
Subject Headings
Sponges, Peroxides, Pathogenic fungi, Candida albicans, Aspergillus fumigatus
Format
Document (PDF)
Sesquiterpene-derived metabolites from the deep water marine sponge Poecillastra sollasi
Title
Sesquiterpene-derived metabolites from the deep water marine sponge Poecillastra sollasi.
Creator
Killday, K. B., Longley, Ross E., McCarthy, Peter J., Pomponi, Shirley A., Wright, Amy E.
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318952
Subject Headings
Sponges --Research, Sesquiterpenes, Marine natural products, Marine metabolites
Format
Document (PDF)
Population dynamics of Vibrio spp. associated with marine sponge microcosms
Title
Population dynamics of Vibrio spp. associated with marine sponge microcosms.
Creator
Hoffmann, M., Fischer, M., Ottesen, A., McCarthy, Peter J., Lopez, Jose V., Brown, E. W., Monday, S. R.
Date Issued
2010
PURL
http://purl.flvc.org/FCLA/DT/3351984
Subject Headings
Sponges, Vibrio, Microbial ecology, RNA, Ribosomal, 16S
Format
Document (PDF)
Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii
Title
Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii.
Creator
Wangun, H. V. K., Wood, A., Fiorilla, C., Reed, John K., McCarthy, Peter J., Wright, Amy E.
Date Issued
2010
PURL
http://purl.flvc.org/FCLA/DT/3319112
Subject Headings
Crinoidea, Marine natural products, Cytotoxin, Marine metabolites, Anthraquinones
Format
Document (PDF)
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands
Title
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands.
Creator
Pomponi, Shirley A., Reed, John K., Wright, Amy E., McCarthy, Peter J.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3351966
Subject Headings
Sponges--Turks and Caicos Islands, Bioactive compounds, Marine natural products, Sponges, Demospongiae
Format
Document (PDF)
Two distinct microbial communities revealed in the sponge Cinachyrella
Title
Two distinct microbial communities revealed in the sponge Cinachyrella.
Creator
Cuvelier, Marie L., Blake, Emily, Mulheron, Rebecca, McCarthy, Peter J., Blackwelder, Patricia, Thurber, Rebecca L. Vega, Lopez, Jose V.
Date Issued
2014-11-04
PURL
http://purl.flvc.org/fau/fd/FAUIR000172
Format
Citation
Comparison of the anaerobic microbiota of deep-water Geodia spp. and sandy sediments in the Straits of Florida
Title
Comparison of the anaerobic microbiota of deep-water Geodia spp. and sandy sediments in the Straits of Florida.
Creator
Bruck, W. M., Bruck, T. B., Self, W. T., Reed, John K., Nitecki, S. S., McCarthy, Peter J.
Date Issued
2010
PURL
http://purl.flvc.org/FCLA/DT/3351982
Subject Headings
Microbial ecology, Marine sediments, Florida, Straits of, Fluorescence in situ hybridization, Sponges
Format
Document (PDF)
Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella
Title
Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella.
Creator
Gunasekera, Sarath P., McCarthy, Peter J., Longley, Ross E., Pomponi, Shirley A., Wright, Amy E.
Date Issued
1999
PURL
http://purl.flvc.org/FCLA/DT/3172682
Subject Headings
Sponges --Caribbean Sea, Marine natural products, Toxicity testing --In vitro, Phosphatases, Peptidase
Format
Document (PDF)
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella
Title
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
Creator
Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Kelly-Borges, M., Chin, M., Sills, Matthew A.
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3333007
Subject Headings
Sponges, Receptor, Endothelin A, Marine natural products, Anti-Infective Agents
Format
Document (PDF)
An Assessment of Fecal Pollution in the St. Lucie Estuary and Indian River Lagoon
Title
An Assessment of Fecal Pollution in the St. Lucie Estuary and Indian River Lagoon.
Creator
Perricone, Carlie S., McCarthy, Peter J., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
Contamination of recreational waters with fecal waste, indicated by the presence of enterococci, can have consequences for human and ecosystem health. The difficulty in determining the extent and origin of fecal pollution in dynamic estuarine systems is compounded by contributions from sources including septic tanks and agricultural runoff. This study investigated fecal pollution at five sites with variable hydrological conditions in the St. Lucie Estuary and Indian River Lagoon. The...
Show moreContamination of recreational waters with fecal waste, indicated by the presence of enterococci, can have consequences for human and ecosystem health. The difficulty in determining the extent and origin of fecal pollution in dynamic estuarine systems is compounded by contributions from sources including septic tanks and agricultural runoff. This study investigated fecal pollution at five sites with variable hydrological conditions in the St. Lucie Estuary and Indian River Lagoon. The distribution and occurrence of enterococci was assessed using traditional cultivation. A human-associated microbial source tracking assay was validated and applied in these estuaries using qPCR. Results demonstrated a correlation between enterococci concentrations, rainfall, and salinity. The human-associated assay was sensitive and specific in the lab; however, human fecal pollution was not detected in the field even though samples contained high levels of enterococci. This study highlights the importance of expanding the range of water quality assessment.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00005023, http://purl.flvc.org/fau/fd/FA00005932
Subject Headings
Dissertations, Academic -- Florida Atlantic University, Indian River (Fla. : Lagoon), Saint Lucie River Estuary (Fla.), Enterococcus., Fecal matter., Estuarine pollution.
Format
Document (PDF)
Novel Detection Techniques for Viable but Nonculturable Vibrio Vulnificus Cells in Response to Elevated Salinity
Title
Novel Detection Techniques for Viable but Nonculturable Vibrio Vulnificus Cells in Response to Elevated Salinity.
Creator
McHenry, Brandon, McCarthy, Peter J., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
Vibrio vulnificus is a marine pathogen of human health concern, capable of causing potentially fatal wound infections in a select group of the population. Previous studies have indicated this species’ strong negative correlation with salinity, not typically found above 30 ppt. This study assessed the ability of V. vulnificus to become Viable But Nonculturable in response to elevated salinity (35 ppt) as well as investigated novel methods for confirming their entrance into this state. Results...
Show moreVibrio vulnificus is a marine pathogen of human health concern, capable of causing potentially fatal wound infections in a select group of the population. Previous studies have indicated this species’ strong negative correlation with salinity, not typically found above 30 ppt. This study assessed the ability of V. vulnificus to become Viable But Nonculturable in response to elevated salinity (35 ppt) as well as investigated novel methods for confirming their entrance into this state. Results showed a complete loss of culturability in both Environmental and Clinical strains of this bacterium by 9 days after inoculation. Using a High Content Imager, it was determined that these pathogens were not dying (< 10%) in response to the treatment and were partially becoming cocci (≈35%). This study indicates the importance of understanding the impact environmental parameters have on this human pathogen, and what it means for reliably detecting them.
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Date Issued
2019
PURL
http://purl.flvc.org/fau/fd/FA00013240
Subject Headings
Vibrio vulnificus, Pathogenic microorganisms--Detection, Salinity
Format
Document (PDF)
The Occurrence of Vibrio vulnificus, V. parahaemolyticus and V. cholerae in the Indian River Lagoon, Florida, with Implications for Human Health
Title
The Occurrence of Vibrio vulnificus, V. parahaemolyticus and V. cholerae in the Indian River Lagoon, Florida, with Implications for Human Health.
Creator
Barbarite, Gabrielle M., McCarthy, Peter J., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
Vibrio bacteria are emerging pathogens responsible for 80,000 illnesses and 100 deaths in the United States each year. Infections are directly linked to the marine environment and are acquired by consuming contaminated seafood or exposing wounds during aquatic activities. Florida has the highest national incidence of vibriosis, with 20% of its cases reported from the Indian River Lagoon region, a popular recreation destination. This study utilized a combination of cultivation and molecular...
Show moreVibrio bacteria are emerging pathogens responsible for 80,000 illnesses and 100 deaths in the United States each year. Infections are directly linked to the marine environment and are acquired by consuming contaminated seafood or exposing wounds during aquatic activities. Florida has the highest national incidence of vibriosis, with 20% of its cases reported from the Indian River Lagoon region, a popular recreation destination. This study utilized a combination of cultivation and molecular techniques to investigate the local distribution of V. vulnificus, V. parahaemolyticus and V. cholerae in this local waterway. The targeted species were found in an array of samples which may facilitate their transmission to humans. Overall, these bacteria were abundant in estuarine sediments (Vp: 2,439 CFU/g, Vv: 303 CFU/g, Vc: 176 CFU/g), on the sharp edges of oyster shells (Vp: 82 CFU/cm, Vv: 102 CFU/cm, Vc: 41 CFU/cm), and in the water column (Vp: 3.78 CFU/ml, Vv: 5.51 CFU/ml, Vc: 2.46 CFU/ml). Vibrio also pose a hazard to recreational anglers as they were recovered from fish (Vp: 61%, Vv: 55%, Vc: 30%), live bait shrimp (Vp: 80%, Vv: 37%, Vc: 0%) and hooks (Vp: 32%, Vv: 18%, Vc: 0%). Additionally, a molecular analysis of the V. vulnificus virulence revealed that the local population was dominated by disease-causing (vcgC) strains, which may explain why wound-related infections are common in this region. Vibrio occurrence varied both spatially and temporally due to their relationship with salinity and temperature. These bacteria exhibited a strong negative correlation with salinity, being particularly abundant near freshwater discharge locations. Due to Florida’s year-round warm climate, these species were found to be permanent members of the local microbial community. Seasonal peaks in abundance occurred between August and October, a period which corresponds with the warmest water temperatures as well as frequent rainfall. Predictive models were constructed based on these parameters to provide a better understanding of how, when and where Vibrio spp. may be encountered by humans. This information is important for both water management and healthcare initiatives, with an overall goal of improving local recreational safety.
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004705
Subject Headings
Health risk assessment, Marine microbiology, Pathogenic microorganisms, Vibrio infections, Vibrionaceae
Format
Document (PDF)
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
Title
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator
Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3333011
Subject Headings
Sponges, Macrolides, Marine natural products
Format
Document (PDF)
Characterization and optimization of in vitro assay conditions for (1,3)β-glucan synthase activity from Aspergillus fumigatus and Candida albicans for enzyme inhibition screening
Title
Characterization and optimization of in vitro assay conditions for (1,3)β-glucan synthase activity from Aspergillus fumigatus and Candida albicans for enzyme inhibition screening.
Creator
Wood, R. L., Miller, T. K., Wright, Amy E., McCarthy, Peter J., Taft, C. S., Pomponi, Shirley A., Selitrennikoff, Claude, Harbor Branch Oceanographic Institute
Date Issued
1998
PURL
http://purl.flvc.org/FCLA/DT/3351974
Subject Headings
Aspergillus fumigatus, Candida albicans, Glucosyltransferases, In vitro, Glucan synthase, Enzyme inhibitors
Format
Document (PDF)
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix
Title
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix.
Creator
Wright, Amy E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, Susan H., Guzman, Esther A., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2009
PURL
http://purl.flvc.org/FCLA/DT/3319109
Subject Headings
Sponges --Research, Marine metabolites, Marine natural products, Hexactinellida
Format
Document (PDF)

Pages